Pattern of Health-Related Quality of Life and its Association among Patients with Colorectal Cancer

Magaji, Bello Arkilla; Moy, Foong Ming; Law, Chee Wei; Sii, Hoe Leong; Roslani, April Camilla

doi:10.31557/apjcc.2019.4.2.45-52

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…It is well established that poorer HRQoL, when measured cross-sectionally [ 31 , 32 , 52 ], is a prognostic marker for shorter survival, a factor also observed in this study with the 15D score. This should be interpreted with caution as it includes guarantee-time bias due to the study setting.…”

Section: Discussionsupporting

confidence: 78%

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Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Lehtomäki

Stedt

Osterlund

et al. 2022

Cancers

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Metastasectomy and/or local ablative therapy in metastatic colorectal cancer (mCRC) patients often provide long-term survival. Health-related quality of life (HRQoL) data in curatively treated mCRC are limited. In the RAXO-study that evaluated repeated resectability, a multi-cross-sectional HRQoL substudy with 15D, EQ-5D-3L, QLQ-C30, and QLQ-CR29 questionnaires was conducted. Mean values of patients in different treatment groups were compared with age- and gender-standardized general Finnish populations. The questionnaire completion rate was 444/477 patients (93%, 1751 questionnaires). Mean HRQoL was 0.89–0.91 with the 15D, 0.85–0.87 with the EQ-5D, 68–80 with the EQ-5D-VAS, and 68–79 for global health status during curative treatment phases, with improvements in the remission phase (disease-free >18 months). In the remission phase, mean EQ-5D and 15D scores were similar to the general population. HRQoL remained stable during first- to later-line treatments, when the aim was no longer cure, and declined notably when tumour-controlling therapy was no longer meaningful. The symptom burden affecting mCRC survivors’ well-being included insomnia, impotence, urinary frequency, and fatigue. Symptom burden was lower after treatment and slightly higher, though stable, through all phases of systemic therapy. HRQoL was high in curative treatment phases, further emphasizing the strategy of metastasectomy in mCRC when clinically meaningful.

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Section: Discussionsupporting

confidence: 78%

“…Symptoms more profoundly affecting CRC survivors’ well-being, in this study as well as in others, are insomnia, impotence, urinary frequency, and fatigue [ 32 , 52 ]. Sexual activity, sexual interest, and dyspareunia were also strongly disturbed in both genders, but more severely in women.…”

Section: Discussionmentioning

confidence: 75%

Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Lehtomäki

Stedt

Osterlund

et al. 2022

Cancers

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“…The mean EQ-5D-5L index values of 0.45 was also lower when compared to those of 0.61 in the study carried out in China (24). A signi cant part of this difference can be explained by using the different tariffs of EQ-5D-5L in two study.…”

Section: Discussionmentioning

confidence: 63%

Utility Values in Colorectal Cancer Patients Treated with Chemotherapy

Atfannezhad

Sharifi

Madadizadeh

et al. 2021

Cancer Investigation

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PurposeThe purpose of present study was to calculate utility values in colorectal cancer (CRC) patients by EQ-5D-5L and cTTO. MethodsThe EQ-5D-5L and cTTO were used to calculate utility values in the patients. A total of 105 patients with CRC were consecutively selected from chemotherapy ward of the Oncology Center of Omid in the second most population province, Isfahan, in Iran. The difference between mean utility values in each factor examined by the t-test and ANOWA. Finally, The BetaMix was used to identify predictors of the utility. ResultsThe mean EQ-5D-5L index and cTTO values were 0.45 ±0.03 and 0.51±0.02, respectively. The anxiety and pain were the most common problems reported by the patients. Univariate analyses showed that the difference between the mean EQ-5D-5L index values were signi cant for age, education status, income level, stage of cancer, and comorbidity number; also, showed that the difference between the mean cTTO values were signi cant for age, income level, employment status, stage of cancer, and comorbidity number. The BetaMix showed that lower mean utility values were signi cantly associated with female, aging, a low level of income, a greater number of comorbidities and advanced stage of cancer. ConclusionThe factors of female, aging, a low level of income, advanced stage of cancer, and a greater number of comorbidities should be considered for improving values of utility. In addition, focusing on anxiety/depression through nancial and social supports can be critical for the improvement in the quality of life in the patients.

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“…With the increasing post-treatment survival rate, information on the pattern of quality of life and its related factors are critical in guiding the treatment options. Typical symptoms such as fatigue, sleep loss, frequency in urination and constipation are among the symptoms occuring post cancer trearment (Magaji et al, 2019).…”

Section: Survival Rate and Prognostic Factors For Colorectal Cancer I...mentioning

confidence: 99%

Survival Rate and Prognostic Factors for Colorectal Cancer in Sabah, Borneo, Malaysia: A Retrospective Cohort of a Population-Based Study

Amir

Avoi

Yusof

et al. 2022

Asian Pac J Cancer Prev

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Pattern of Health-Related Quality of Life and its Association among Patients with Colorectal Cancer

Cited by 12 publications

References 30 publications

Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Utility Values in Colorectal Cancer Patients Treated with Chemotherapy

Survival Rate and Prognostic Factors for Colorectal Cancer in Sabah, Borneo, Malaysia: A Retrospective Cohort of a Population-Based Study

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