Pattern of growth of a gastric inflammatory fibroid polyp with PDGFRA overexpression

Yamashita, K.; Arimura, Yoshiaki; Tanuma, Tokuma; Endo, Takeshi; Hasegawa, Toshimichi; Shinomura, Yasuhisa

doi:10.1055/s-0030-1256289

Cited by 8 publications

(8 citation statements)

References 4 publications

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“…The lesions have been regarded as inflammatory and reactive. However, recent studies have demonstrated that the spindle cells in IFP express PDGFRA, and the majority of IFPs harbor activating PDGFRA mutations [6–8]. Therefore, IFPs represent true benign mesenchymal tumors of the gastrointestinal tract [6–8].…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, an IFP is characterized by a mixture of numerous small vessels, fibroblast‐like spindle cells, and edematous connective tissue associated with marked inflammatory infiltration by eosinophils and plasma cells [5]. Recent studies showed that mutation and activating platelet‐derived growth factor receptor alpha (PDGFRA) contribute to the development of IFP [6–8]. Therefore, an IFP represents a true benign tumor of a reactive inflammatory lesion [6–8].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies showed that mutation and activating platelet‐derived growth factor receptor alpha (PDGFRA) contribute to the development of IFP [6–8]. Therefore, an IFP represents a true benign tumor of a reactive inflammatory lesion [6–8]. The proliferative fibroblast‐like spindle cells in IFP have strong immunostains to PDGFRA [6], and these cells are also focal stain to CD34 [9].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, an IFP represents a true benign tumor of a reactive inflammatory lesion [6–8]. The proliferative fibroblast‐like spindle cells in IFP have strong immunostains to PDGFRA [6], and these cells are also focal stain to CD34 [9]. Currently, an IFP is considered a benign tumor having no malignant potential as neither recurrence nor metastasis have been observed [10].…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory fibroid polyp of rectum mimicking rectal cancer

Jin

Yeh

et al. 2013

The Kaohsiung J of Med Scie

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Inflammatory fibroid polyps (IFPs) are rare benign tumors of the rectum. Mutation and activating platelet-derived growth factor receptor alpha (PDGFRA) contribute to tumor development. We present a case of IFPs in the middle rectum that mimic rectal cancer. A 65-year-old woman presented with the symptom of fresh blood in the stool and body weight loss of 6 kg in the preceding 3 weeks. A rectal polypoid tumor was noted upon digital examination. Sigmoidoscopy showed a middle rectal tumor measuring 3 × 2.7 cm with obstruction. Computed tomography (CT) scans of the abdomen showed a rectal tumor that had invaded the sacral bone and was associated with four enlarged lymph nodes greater than 1 cm. The radiological report suggested a diagnosis of rectal cancer with lymph node metastases. To remove the obstruction, the patient was initially treated with excision of the tumor and loop sigmoidal colostomy to the abdomen wall. Total mesorectal resection of rectal and sacral tumor followed 10 days later. Histopathological examination of the rectal and sacral tumor showed proliferation of vessels, fibroblast-like spindle cells, and mixed inflammatory cells, including the plasma cells and eosinophils. The spindle cells were diffusely positive to PDGFRA and were focal positive to CD34 and smooth muscle actin. Based on histopathological and immunohistochemical findings, the diagnosis of IFP is indicated. This was the first reported case of IFPs of the rectum presenting with lymph node enlargement and attachment to the sacrum mimicking rectal cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inflammatory fibroid polyp of rectum mimicking rectal cancer

Jin

Yeh

et al. 2013

The Kaohsiung J of Med Scie

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“…Genetically, there were no mutations in the PDGFRA exons. We previously reported a case of a gastric IFP in a 73‐year‐old man . The polyp was removed endoscopically and pathologically diagnosed as an IFP.…”

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confidence: 99%

Colonic inflammatory fibroid polyp with PDGFRA expression

Sugawara

Sugita

Tateno

et al. 2017

Pathology International

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Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps

et al. 2014

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Inflammatory fibroid polyps are rare mesenchymal lesions. The frequency of Helicobacter pylori infection in the gastric mucosa overlying inflammatory fibroid polyps and its relation with the histologic features of the polyps are undetermined. The clinico-pathological features of inflammatory fibroid polyps, the frequency of Helicobacter pylori infection in the overlying gastric mucosa, and its putative impact on the phenotype of the polyps were evaluated. Gastric inflammatory fibroid polyps diagnosed in our Hospital from 1998 to 2012 were reviewed and the histological. The histological sections were stained with hematoxylin and eosin and modified Giemsa for the evaluation of Helicobacter pylori infection. Inconclusive cases were further analyzed by immunohistochemistry with anti-Helicobacter pylori antibody. Diagnosis was confirmed in 54 polyps, 85 % developed in females, mean age 63 ± 11 years. Most polyps were sessile (74 %), with a mean size of 15 ± 12 mm, 96 % were located in the antrum and 85 % were removed by snare polypectomy. Helicobacter pylori infection was identified in 48 % of the polyps. Most inflammatory fibroid polyps developed in the submucosa, and mucosal extension was observed in 96 % of the cases. Chronic gastritis was observed in all cases (63 % with activity, 31 % with intestinal metaplasia, and 61 % with foveolar hyperplasia). Erosion and ulceration of the overlying gastric mucosa was observed in 48 % and 11 % of the polyps, respectively. Onion skin features were present in 52 % of the polyps and were more frequently observed in cases without evidence of Helicobacter pylori infection. Background changes in gastric mucosa were not distinctive according to Helicobacter pylori infection. Chronic atrophic gastritis with intestinal metaplasia was associated with the presence of perivascular onion skin lesions. To our knowledge, this is the second largest series of gastric inflammatory fibroid polyps. Helicobacter pylori infection was identified in about half of the cases and was associated with a lower frequency of onion skin features in the polyps.

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Pattern of growth of a gastric inflammatory fibroid polyp with PDGFRA overexpression

Cited by 8 publications

References 4 publications

Inflammatory fibroid polyp of rectum mimicking rectal cancer

Inflammatory fibroid polyp of rectum mimicking rectal cancer

Colonic inflammatory fibroid polyp with PDGFRA expression

Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps

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