Pattern Of Drug Induced Hyperuricaemia In Nigerians With Pulmonary Tuberculosis

Ruta graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity through Modulation of Oxidative Stress and Inflammation

“…These measurements are often regarded as reliable markers of kidney damage [31] and indicate the loss of a majority of kidney function [32]. These elevated assessments are in agreement with the studies of Hashmi et al [33], who reported increased serum levels of creatinine and urea in albino rabbits following administration of antituberculosis drugs.…”

Expression profile of markers of oxidative stress, injury and apoptosis in anti‐tuberculosis drugs induced nephrotoxicity

“…This study revealed that 28 days oral administration of rifampicin, isoniazid, and pyrazinamide has induced glomerular dysfunction that leads to kidney injury, which can be affirmed by the increased levels of kidney function markers urea, creatinine, and uric acid in blood circulation. These are considered as committed markers of nephritic injury and suggest the loss of a major part of kidney function . These anti‐TB drugs also lead to elevation of cholesterol, which can be due to deposition of fat in the liver, latter develops either due to lipids oversupply or interference with lipid accumulation mechanisms .…”

The Non-Enzymatic Antioxidant and Level of Oxidative Stress of Tuberculosis Patients in Selected Treatment Center in Addis Ababa Ethiopia

“…In contrast with this, a study [35] conducted in Nigeria indicated that there was an increases in uric acid level of newly diagnosed pulmonary tuberculoses patients than normal control. Many studies [36] [37] also mentioned that there is an increase in uric acid during the course of anti TB therapy no signs of clinical gout or arthralgias. But fortunately it was also shown that the results returned back to normal once the drug was stopped.…”