Pattern of clinically recognisable congenital malformations in babies born in a tertiary referral centre in Sri Lanka

Fernando, S.; Bandara, Thushari; Sathanantharajah, R; Withanaarachchi, K

doi:10.4038/cmj.v59i4.7866

Cited by 6 publications

(9 citation statements)

References 13 publications

(15 reference statements)

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“…R (31) Pattern of clinically recognisable congenital malformations in babies born in a tertiary referral centre in Sri Lanka.…”

Section: J (23)mentioning

confidence: 99%

“…Dentre os tipos de AC mais identificadas nos artigos revistos destacam-se as do Sistema Cardiovascular, Musculoesquelético, Osteomuscular (20) e Urogenital (15) , e as mais detectadas por exame de imagem pré-natal foram às do Sistema Nervoso Central, as Cardíacas (23) e Osteomusculares (20) . Em uma das pesquisas, as anormalidades musculoesqueléticas, com 30% dos casos, eram deformidades dos pés, do quadril, hemangioma, prega de pele pré-auricular, seio e manchas hipopigmentadas pré-auriculares (31) . E 30% estavam relacionadas ao Sistema Digestório, predominando a anquiloglossia (quase 90%); 18,2% do Sistema Gênito-urinário como a criptorquidia; 10,3% do Sistema Circulatório, com doenças cardíacas de baixo risco; 7,9% do Sistema Neurológico, predomínio da hidrocefalia, anomalia sacral, e encefalocele; 3% de anormalidades cromossômicas como a Síndrome de Down; 2,9% fissuras lábio palatais; e 0,8% as anormalidades de olhos, ouvidos e pescoço (31) .…”

Section: Variáveis Do Recém-nascidounclassified

“…Em uma das pesquisas, as anormalidades musculoesqueléticas, com 30% dos casos, eram deformidades dos pés, do quadril, hemangioma, prega de pele pré-auricular, seio e manchas hipopigmentadas pré-auriculares (31) . E 30% estavam relacionadas ao Sistema Digestório, predominando a anquiloglossia (quase 90%); 18,2% do Sistema Gênito-urinário como a criptorquidia; 10,3% do Sistema Circulatório, com doenças cardíacas de baixo risco; 7,9% do Sistema Neurológico, predomínio da hidrocefalia, anomalia sacral, e encefalocele; 3% de anormalidades cromossômicas como a Síndrome de Down; 2,9% fissuras lábio palatais; e 0,8% as anormalidades de olhos, ouvidos e pescoço (31) . No Chile, estudo demonstrou que a Síndrome de Down apresentou incremento de 47%, entre 1982 a 2010, embora taxas globais apresentaram-se estáveis (25) .…”

Section: Variáveis Do Recém-nascidounclassified

“…A suplementação de ácido fólico reduziu em 50% o risco de anencefalia e espinha bífida, quando comparado às mulheres que não o usaram (21,26) . Destarte, o início precoce do pré-natal é imprescindível para prevenção de AC (21,31) , devido à vacinação, a suplementações com ácido fólico, a realização de exames de imagem para diagnósticos precoce, e o favorecimento do planejamento do parto em serviços de referência, com Unidades de Terapia Intensiva Neonatal.…”

Section: Variáveis Assistenciaisunclassified

“…Substancias teratógenas, como álcool, drogas, medicamentos e chumbo interferem no desenvolvimento embrionário, desencadeando importantes AC (21,31) . Em estudo epidemiológico da China, das mulheres que deram à luz a recém-nascidos com AC, evidenciou-se que quase 3% contraíram infecção viral, quase 10% utilizaram medicamentos na gravidez, e quase 4% aproximaram-se de substâncias nocivas (26) .…”

Section: Variáveis Assistenciaisunclassified

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Evid�ncias cient�ficas dos fatores de risco para anomalias cong�nitas: revis�o integrativa

Barros¹,

Freira²,

Migoto³

2017

R. Enferm. Cent. O. Min.

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Objetivo: Identificar atrav�s da produ��o cient�fica atual os fatores de risco para a ocorr�ncia dos nascimentos com Anomalias Cong�nitas. M�todos: Este estudo buscou identificar os fatores de risco para a ocorr�ncia dos nascimentos com Anomalias Cong�nitas nas publica��es cient�ficas, dos �ltimos 30 meses, de janeiro de 2014 at� junho de 2016. Trata-se de uma revis�o integrativa, com base nas recomenda��es de Ganong. Resultados: Foram selecionados 19 artigos, com resultados organizados em cinco blocos referentes: a) m�e do rec�m-nascido com anomalias cong�nitas, b) ao rec�m-nascido, c) � assist�ncia ao bin�mio, d) aos diagn�sticos, e) �s pol�ticas p�blicas e informa��o do evento vital - nascimento com anomalias cong�nitas. Conclus�o: S�o necess�rias pol�ticas p�blicas de sa�de para a melhoria do acesso precoce ao pr�-natal e da sua qualidade al�m de melhoria de acesso dessas crian�as e suas fam�lias a tratamento adequado.�

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“…R (31) Pattern of clinically recognisable congenital malformations in babies born in a tertiary referral centre in Sri Lanka.…”

Section: J (23)mentioning

confidence: 99%

Section: Variáveis Do Recém-nascidounclassified

Section: Variáveis Assistenciaisunclassified

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Evid�ncias cient�ficas dos fatores de risco para anomalias cong�nitas: revis�o integrativa

Barros¹,

Freira²,

Migoto³

2017

R. Enferm. Cent. O. Min.

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Correlates of knowledge on birth defects and associated factors among antenatal mothers in Galle, Sri Lanka: a cross-sectional analytical study

Silva

Amarasena

Jayaratne

et al. 2019

BMC Pregnancy Childbirth

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BackgroundBirth defects (BD) are considered a leading cause of childhood morbidity and mortality. Personal, cultural, and health care system barriers may increase the incidence of BD in low and middle income countries. In this study we assessed the knowledge of antenatal mothers on BD, associated factors, and prevention and management.MethodsThree hundred and fifty (350) antenatal mothers were surveyed using a pretested, self-administered questionnaire. The knowledge on BD was evaluated under 3 categories; knowledge on BD, knowledge on associated factors, and knowledge on prevention and management. The total scores were calculated for each category and converted into percentages. A higher percentage score indicates a high level of knowledge. Descriptive statistics and regression models were used for data analysis. Level of significance was considered as p < 0.05.ResultsMean age of the participants was 28.7 years (SD = 5.2). The age range was 17–44 years. Most of the participants (79%) had studied up to secondary or tertiary education. The average scores of knowledge on BD, associated factors, and prevention and management of BD were 57.6% (95% CI = 52.3–62.9%), 55.1% (95% CI = 49.8–60.4%) and 58.8% (95% CI = 53.5–64.1%) respectively. The average score on the overall total knowledge was 56.4% (95% CI = 51.1–61.7%). Mother’s level of education, monthly income of the family and number of clinic visits made by the mother were found to be positively associated with the overall knowledge. About 62% of the participants had taken folic acid (FA) preconceptionally, a major preventive factor of BD associated with the nervous system. Folic acid intake was positively associated with age and educational level, but negatively associated with parity. Media (36.9%) and Public Health Midwives (PHMs) (20%) were found to be the major sources of knowledge on BD, associated factors and prevention in this target group.ConclusionsThe average overall knowledge on BD in this group of antenatal mothers was moderate. Thus, there is a need to improve the knowledge in eligible women to reduce the occurrence of BD, ideally before they become pregnant. Media and PHMs were seem to be the effective and possible resources that can be used to educate the community on BD, associated factors and prevention of BD in Sri Lanka.Electronic supplementary materialThe online version of this article (10.1186/s12884-018-2163-9) contains supplementary material, which is available to authorized users.

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Survey of Risk Factors During Pre- and Post-Conception Periods in Mothers of Babies with Structural Birth Defects Seen at a Tertiary Hospital in Nigeria

Ugwu¹,

Eneh²

2016

Int. J. Pediatr. Child Health

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Background: Although some birth defects have a genetic origin, certain factors in the mother may have a direct effect on fetal development and increase the risk of having a baby with birth defect. Objectives: To assess the prevalence of risk factors during the pre- and post-conception periods in mothers of babies with birth defects at the University of Port Harcourt Teaching Hospital, Nigeria. Method: Data from an ongoing study on birth defects at the University of Port Harcourt Teaching Hospital were extracted for neonates seen from January 2006 to December 2011. Sociodemographic data and information on pre-and post-conception exposure of the mothers to risk factors were obtained using a semi-structured questionnaire. Each child was examined to describe the type and extent of defect(s). Results: Birth defect was identified in 501 (8.9%) out of 5,604 babies admitted within the study period. There were 273 (54.5%) males, 220 (43.9%) females and 8(1.6%) with indeterminate gender. The mean gestational age at delivery was 38.5±2.6 weeks and the mean birth weight was 2846±885g. The mean maternal age was 29.1±5.2 years with 412 (82.2%) being less than 35 years. The preconception and post conception risk factors identified include overweight/obesity 256 (51%), alcohol consumption 208 (41.5%), low socioeconomic status 217 (43.3%), non-medical abortion 245(34.7%), use of therapeutic drugs that are teratogenic (27.5%) and local herbs (23.8%). A hundred and twenty-six (17.8%) had a history of repeated miscarriages, 52 (10.4%) had hypertension while 20(4%) had diabetes. In 22 (4.4%) babies, there was a positive family history of a previous birth defect. Seventeen mothers (3.4%) had attempted unsuccessfully to terminate the index baby with birth defect using alcohol-based native herbs. In 198 (39.5%), no risk factors were documented. Conclusion: Overweight/obesity, low socioeconomic status and alcohol consumption pre- and post-conceptually appears to be major risk factors for the occurrence of birth defects in babies delivered to these rather young women in the Niger Delta. Maternal risk factors should be assessed in order to provide modifications during preconception care for a better pregnancy outcome.

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Pattern of clinically recognisable congenital malformations in babies born in a tertiary referral centre in Sri Lanka

Abstract: Prevalence of CM in the study group is high compared to other countries in the region. Emphasis on preventing CM is recommended and public health actions is required in improving well-being of affected babies.

Cited by 6 publications

References 13 publications

Evid�ncias cient�ficas dos fatores de risco para anomalias cong�nitas: revis�o integrativa

Evid�ncias cient�ficas dos fatores de risco para anomalias cong�nitas: revis�o integrativa

Correlates of knowledge on birth defects and associated factors among antenatal mothers in Galle, Sri Lanka: a cross-sectional analytical study

Survey of Risk Factors During Pre- and Post-Conception Periods in Mothers of Babies with Structural Birth Defects Seen at a Tertiary Hospital in Nigeria

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