Pattern of brain tissue loss associated with freezing of gait in Parkinson disease

Kostić, Vladimir; Agosta, Federica; Pievani, Michela; Stefanova, Elka; Ječmenica-Lukić, Milica; Scarale, Antonio; Špica, Vladana; Filippi, Massimo

doi:10.1212/wnl.0b013e318245d23c

Cited by 123 publications

(92 citation statements)

References 39 publications

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“…The present findings disagree with Goldman et al (2014), who found reduced GM volume in bilateral precentral gyrus (Goldman et al, 2014), and with other studies that found reduced GM in left precentral gyrus (Kostic et al, 2012;GonzalezRedondo et al, 2014). The precentral gyrus is the origin of the pyramidal tract; therefore, Shao et al (2014) suggested that the impairment of the precentral gyrus may partially contribute to the motor deficits of PD.…”

Section: Grey Matter Volume Of Motor Cortexcontrasting

confidence: 99%

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Shareef¹

2018

Int. j. adv. appl. sci.

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Parkinson's disease (PD) is a neurodegenerative disorder commonly diagnosed as motor triad of symptoms including tremor, rigidity and bradykinesia. The degeneration of the Substantia nigra in PD, leads to alterations in the function of cortical areas including primary motor cortex and other non-primary motor areas. The combination of motor and sensory symptoms marked in PD, is the cause of investigating the structural changes of motor and sensory cortices in PD. The aim of this study is to detect the structural changes of cortical thickness and the volume of grey matter and white matter in motor and sensory cortices in PD. This will help in early detection of the disease, monitor response to medication or help in prognosis and prediction of outcomes. Nineteen control volunteers and 18 Parkinson's patients were participated in the study. The ages of participants were ranging between 45-65 years (mean 56.14 years). Structural magnetic resonance imaging was performed and the Digital Imaging and Communications in Medicine (DICOM) images were evaluated using automatic brain segmentation software (BrainSuite). The structural changes in the present study were found in the thickness of the motor cortex and in the volume of grey matter (GM) of the sensory cortex. The thickness of the right motor cortex for males was smaller in Parkinson's patients than control. The volume of the GM of left sensory cortex for males was smaller in Parkinson's patients than control. While no differences were found between Patients and controls in the volume of GM or white matter (WM) in the motor cortex, or in the volume of WM and the cortical thickness in the sensory cortex. Structural changes in specific areas of the brain may influence specific symptoms.

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Section: Grey Matter Volume Of Motor Cortexcontrasting

confidence: 99%

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Shareef¹

2018

Int. j. adv. appl. sci.

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“…In this study, we used the FreeSurfer implementation of surfacebased analysis and our results demonstrate that patients with FOG exhibited atrophy of the bilateral cingulate cortex (mostly in mid-anterior part), left supplementary motor area (SMA), and right frontal operculum. In summary, earlier publications reported rather complex pattern of functional and morphological changes [6][7][8][9][10][11]29 , suggesting a complex pathophysiological substrate of FOG. Whereas the automatic control of gait appears to be subserved by brainstem nuclei and their corresponding circuits, involvement of cortical brain structures is presumed in FOG because of frequent manifestation of freezing in situations with emotional or cognitive context.…”

Section: Discussionmentioning

confidence: 60%

“…In contrast, when Tessitore et al 6 directly contrasted PD patients with and without FOG, they found GM atrophy in the left cuneus, lingual gyrus, precuneus, and posterior cingulate cortex. On the other hand, when comparing GM atrophy in PD patients with FOG to both control subjects and PD patients with no FOG, Kostic et al 7 observed atrophy of the left inferior frontal gyrus, left precentral gyrus, and left inferior parietal gyrus. Lastly, Herman et al 29 reported that FOG severity correlated with atrophy in the bilateral inferior parietal lobule, right angular gyrus, and bilateral caudate nuclei, although no significant group-wise differences were found.…”

Section: Discussionmentioning

confidence: 99%

“…Although the methods for group comparison of VBM data are highly sophisticated, they are prone to bias from various optional user settings, leading potentially to inconsistencies 4 . Several previous studies investigated the brain alterations associated with FOG in patients with PD using VBM, but they yielded variable outcomes [5][6][7][8][9][10][11] . Because of these differences, potentially related to VBM methodology, it may be worth exploring cortical atrophy with a different method.…”

Section: Introductionmentioning

confidence: 99%

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Freezing of gait is associated with cortical thinning in mesial frontal cortex

Vaštík¹,

Hok²,

Valošek³

et al. 2017

BIOMED PAP

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Aims.The relationship between freezing of gait (FOG) and regional brain atrophy has been intensively investigated, but it is still not clearly understood. The study objective was to test whether grey matter (GM) atrophy contributes to FOG in Parkinson´s disease (PD) using a surface-based algorithm. Methods. We investigated 21 patients with PD, 11 with FOG and 10 without FOG. Both groups were assessed using a FOG questionnaire and Hoehn and Yahr staging. High resolution T1-weighted brain images were acquired for each subject using a 1.5T MRI scanner. A surface-based method implemented in FreeSurfer was used to quantify the GM atrophy. A vertex-wise and region of interest (ROI) comparison of spatially normalized subject data using a general linear model and the Wilcoxon rank sum test were to assess significant group differences. Results. Higher global levels of cortical atrophy were detected in freezers, although this was not statistically significant. The vertex-wise analysis revealed significant local reduction in grey matter thickness in the left supplementary motor area, m iddle/anterior cingulate cortex, temporal pole and right frontal operculum in freezers at P<0.001, uncorrected. The ROI analysis of average thickness confirmed the regional atrophy in bilateral anterior and posterior cingulate cortices. No significant relative regional cortical atrophy was observed in non-freezers. Conclusion. FOG was associated with regional cortical atrophy, especially in mesial frontal and cingulate cortices. Our findings provide additional evidence that the development of FOG in patients with PD is associated with local structural cortical changes.

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“…Some studies have shown distributed brain atrophy in cortical and subcortical regions, including the frontal lobe, temporal lobe, parietal lobe, occipital lobe, and the limbic/paralimbic areas. [1][2][3][4][5][6][7][8] On the other hand, 1 study reported an increase of GM in the thalamus in patients with PD with unilateral resting tremor compared with controls. 9 A recent study has observed not only brain volume loss in the occipital region but also volume increase in the limbic/paralimbic system.…”

mentioning

confidence: 96%

Longitudinal Study of Gray Matter Changes in Parkinson Disease

Jia

Liang

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The pathology of Parkinson disease leads to morphological brain volume changes. So far, the progressive gray matter volume change across time specific to patients with Parkinson disease compared controls remains unclear. Our aim was to investigate the pattern of gray matter changes in patients with Parkinson disease and to explore the progressive gray matter volume change specific to patients with Parkinson disease with disease progression by using voxel-based morphometry analysis.

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Pattern of brain tissue loss associated with freezing of gait in Parkinson disease

Abstract: GM frontal and parietal atrophy occur in PD-FOG patients. FOG in PD seems to share with executive dysfunction and perception deficits a common pattern of structural damage to the frontal and parietal cortices.

Cited by 123 publications

References 39 publications

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Freezing of gait is associated with cortical thinning in mesial frontal cortex

Longitudinal Study of Gray Matter Changes in Parkinson Disease

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