Pattern of bacterial isolates causing neonatal septicemia along with their pattern of antibiotic susceptibility.

Abstract

Objectives: We planned this study to observe the pattern related to bacterial isolates causing neonatal septicemia along with their pattern of antibiotic susceptibility. Study Design: Prospective study. Setting: Department of Neonatology, Sheikh Khalifa Bin Zaid Al Nahyan Teaching Hospital, Rawlakot. Period: From 1st January 2018 to 30th June 2018. Material & Methods: Prior to empiric antibiotic usage, blood was collected from neonates having clinical sepsis and sent for blood culture. A total of 60 neonates with culture proven sepsis were enrolled for this study. Reports of blood culture were evaluated for isolates of bacteria as well as patterns of sensitivity for frequently used antibiotics in the institution. SPSS version 21.0 was used for data entry and analysis. Results: A total of 60 neonates having culture proven sepsis were enrolled in the current study. Amongst these, 39 (65.0) were male and 21 (35.0%) female. Early onset of sepsis was diagnosed in most, 42 (70.0%) neonates. Majority of neonates, 50 (83.3%) were delivered in the same hospital. Gram negative isolates were found in 43 (71.7%) and 15 (25.0%) gram positive while 2 (3.3%) candida spp. In terms of pattern of antibiotic sensitivity, 4 (9.3%) isolates of gram negative were found resistant to every antibiotic routinely used while gram positive isolates showed excellent sensitivity to vancomycin. Conclusion: Gram negative isolates of organisms were found to be the most sensitive to carbepenems (especially meropenem) as well as aminoglycosides while gram positive isolates showed excellent sensitive regarding vancomycin.

Bacteriological Profile in Septicaemic Patients with Elevated C-reactive Protein in Intensive Care Units at A Tertiary Care Hospital

“…Furthermore, the prevalence of culture positive sepsis reported from several ICU in South Asia ranged from 6 to 56%, 52.9% in this study was near comparable with the study by Lisa Mellhammar et al 18 having 54%, most likely is due to discrepancies in study design and terminology. 12, [14][15][16][17][18] In our study culture positivity was 52.9% among elevated CRP Patients similar to the study of Jyoti et al study who also got 49% with CRP elevated above 6mg/dl 12 n a study done by Abera Kumalo culture positivity was a 16% & even low as near 7% in recent study by Bajaj A et al 19 in may be because they did not take CRP positivity as adjunct criteria for selecting samples. 20 In our study, major positive samples were from IMCU (42.6%) similarly higher percentages are seen in other studies also, a study done by Calik Z had highest percentage with 81% of his samples were from IMCU.…”