Pattern of antidiabetic drugs use in type-2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital

Abstract

Background: Diabetes mellitus (DM) is an important public health problem in developing countries. Drug utilisation study of antidiabetic agents is of paramount importance to promote rational drug use in diabetics and make available valuable information for the healthcare team. The aim of study was to investigate the drug utilization pattern in type-2 diabetic patients. Methods: A prospective, cross-sectional study was carried out in medicine outpatient clinic of tertiary care hospital, Ahmedabad for eight weeks. Patients with type-2 diabetes and on drug therapy for at least one month were included. Patients’ socio-demographic and clinical data were noted in a pre-designed proforma. Data was analysed by using SPSS version 20 and Excel 2007. Results: Total 114 patients were enrolled with mean (± standard deviation) age and duration of diabetes of 56.8 ± 10.5 and 8.3 ± 9.4 years respectively. Male: Female ratio was 0.72:1. Mean fasting and postprandial blood glucose levels were 147.5 ± 73.1 and 215.6 ± 97.3 mg/dl respectively. Most common symptom was weakness/fatigue (77.2%). Hypertension (70.2%) was most common co-morbid illness. Mean number of drugs prescribed were 7.8 ± 2.5. Total numbers of patients receiving more than five drugs were 89.5%. Most commonly used drug group was biguanides (87.7%) followed by sulphonylureas (68.4%). Conclusion: Metformin (biguanide) was the most utilized (87.7%) antidiabetic drug for type-2 diabetes. This study revealed that the pattern of antidiabetic prescription was rational and largely compliant with NICE (National Institute for Health and Clinical Excellence) guidelines. [Int J Basic Clin Pharmacol 2013; 2(4.000): 485-491

Utilization pattern of oral hypoglycemic agents for diabetes mellitus type 2 patients attending out-patient department at tertiary care centre in Bhopal

“…17,18 However, the results are in contrast to a few studies conducted in India and other countries which have reported either male or female preponderance. [19][20][21][22][23] Majority of our patients were in the age group of 51-60 years (40%) which is in concordance with the earlier published literature. 17,19,21,24 The mean age of the patients in the present study was 57.6 years (age range: 18-79 years) which is similar to that obtained in studies conducted in Nepal and Ahmedabad in which the mean age of patients was 56.9 and 56.8 years respectively.…”

Evaluation of prescribing pattern of antidiabetic drugs in medicine outpatient clinic of a tertiary care teaching hospital

“…Different studies also reported similar observation with regard to the co-morbidity in patients with diabetes. 8,11,[16][17][18] The average number of drugs per prescription was 3.04 which is comparable to the study from UAE. 8 Prescriptions with 5 and more than 5 drugs were found among patients above 50 years of age and with co-morbidities.…”

“…7,11,15,16,[18][19][20] Among the sulfonylureas, glimepiride was the most commonly prescribed drug along with metformin which is similar to studies. 10,18 Metformin is one of the safest and most cost effective drug compared to other drugs in terms of hypoglycaemia and decreasing BMI, hence this could be the most probable reason for this finding. Also this finding is in accordance with the clinical guidelines given by Canadian Diabetes Association, International Diabetes Federation, and National Institute of Health and Clinical Excellence.…”

An Assessment of Anti-hyperglycemic Drug Utilization Patterns and Adherence to AACE/ACE 2015 Guidelines in South Indian Tertiary Care Teaching Hospital

“…13 Another study published that there was optimal adherence to guidelines in Sweden in home health care settings than residents at nursing homes. 14,15 This study found there was optimal adherence to AACE/ ACE guidelines in our institution resulting in better patient care. In dual therapy, triple and Insulin therapy there was unprecedented adherence.…”