Patterns generated by a colloidal suspension of nanospheres drying on a frictional substrate are studied by experiments and computer simulations. The obtained two-dimensional self-assembled structures are commonly used for nanosphere lithography. A spring-block stick-slip model is introduced for simulating the phenomenon and the influence of several controllable parameters on the final structure is investigated. The model successfully reproduces the experimentally observed patterns and the dynamics leading to pattern formation is revealed.The so-called bottom-up approach for the fabrication of nanostructures starting from stable building blocks such as molecules or nanoparticles has become an increasingly popular topic in nanoscience and nanotechnology. Thanks to the efforts of nanochemists, during the past decades various nanoparticles of polystyrene, silica, noble-metal and semiconductor, nearly monodisperse in terms of size, shape, internal structure, and surface chemistry, can be produced through a reliable, standard manufacturing process. Using these nanoparticles as building blocks, the synthesis of long-range-ordered monolayers and films of colloidal nanocrystals has been in particular focus. The revolutionary development of photonic crystals triggered efforts to get innovative methods for crystallizing polystyrene colloids and creating new crystal structures [1,2]. The use of two-dimensional (2D) selfassembled array of nanometer-sized polystyrene spheres as deposition mask is known as NanoSphere Lithography (NSL) [3]. The homogeneous arrays of nanoparticles produced using NSL are potentially useful in studies of size-dependent optical, magnetic, catalytic and electrical transport properties of materials [3,4,5,6]. NSL is now recognized as a powerful fabrication technique to inexpensively produce nanoparticle arrays with controlled shape, size and interparticle spacing. A fundamental goal for further progress in NSL is the development of experimental protocols to control the interactions, and thereby the ordering of nanoparticles on solid substrates [7,8]. However, it is more and more clear that due to the rich physics and chemistry underlying the formation of nanoparticle arrays from colloidal suspensions, the likelihood of structures other than close-packed networks forming during solvent evaporation is very high [9, 10]. Therefore a major motivation for theoretical research in this field remains the challenge to understand how ordered or complex structures form spontaneously by selfassembly, and how such processes can be controlled in order to prepare structures with a pre-determined geometry [11]. The present study intends to contribute in this sense by proposing a model that can be easily studied through computer simulations and it is able to qualitatively reproduce the wide variety of observed patterns. We focus on an experimentally simple case, when 2D selfassembled arrays of nanometer-sized polystyrene spheres will form from a colloidal suspension which is drying on a substrate. Some characteristi...