Pattern ERG and glaucomatous visual field defects

Berg, T. J. T. P. Van Den; Riemslag, Frans C. C.; Vos, G. W. G. A. De; Lunel, H. F. E. Verduyn

doi:10.1007/bf00142361

Cited by 34 publications

(6 citation statements)

References 18 publications

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“…We converted PERGLA amplitude values from microvolts to decibels for comparison with SAP central 16 locations and SAP MD and PSD and demonstrated a modest correlation supporting the observations of other investigators 31, 35, 37, 51, 55–58. The PERGLA stimulus subtends a 25-degree visual angle, which compares to the central 16 test locations on the SAP visual field.…”

Section: Discussionsupporting

confidence: 77%

Relationship Between Pattern Electroretinogram, Standard Automated Perimetry, and Optic Nerve Structural Assessments

Sehi

Pinzon-Plazas

Feuer

et al. 2009

Journal of Glaucoma

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Purpose-To examine the relationship between retinal ganglion cell function measured using pattern electroretinogram optimized for glaucoma screening (PERGLA), retinal nerve fiber layer (RNFL) thickness and optic nerve head topography.Methods-Twenty-nine normal, 28 glaucoma and 37 glaucoma suspect volunteers were enrolled. All participants were age-similar. One randomly selected eye underwent complete eye examination, standard automated perimetry (SAP), scanning laser polarimetry with enhanced corneal compensation (GDxECC), optical coherence tomography (OCT), Heidelberg retina tomograph (HRT) and PERGLA measurements. PERGLA amplitude (microvolt) was converted to decibel for comparison with SAP mean deviation (MD) and pattern standard deviation. The correlation between PERGLA amplitude in dB and the average of sensitivity values for 16 central test locations of SAP were calculated. Analysis of variance, Pearson and Spearman rank correlations, coefficient of variation (CoV) and intraclass correlation coefficients (ICC) were calculated.Results-PERGLA amplitude in glaucomatous eyes was significantly lower than normal eyes (0.47 ± 0.20 vs. 0.70 ± 0.28 μv, p < 0.001) but not glaucoma suspects (0.54 ± 0.21 μv, p = 0.84). PERGLA amplitude was inversely correlated with age (r = −0.31, p = 0.002). PERGLA amplitude (in dB) was associated with the sensitivity values of the SAP central 16 test locations (r = 0.40, p < 0001) across the entire cohort, GDxECC superior RNFL thickness (r = 0.38, p < 0.001) and HRT Moorfields regression analysis classification (rho = −0.34, p = 0.001). The CoV and ICC were 14.5% and 0.89 for PERGLA amplitude, 2.4% and 0.98 for OCT average RNFL, 2.2% and 0.97 for GDxECC TSNIT average and 6.3% and 0.94 for HRT rim area.Conclusion-Retinal ganglion cell function measured using PERGLA is reduced in glaucoma and demostrates modest correlations with central SAP sensitivity values, and structural measures of optic nerve topography and RNFL thickness.

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Section: Discussionsupporting

confidence: 77%

Relationship Between Pattern Electroretinogram, Standard Automated Perimetry, and Optic Nerve Structural Assessments

Sehi

Pinzon-Plazas

Feuer

et al. 2009

Journal of Glaucoma

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“…56 -73 All but one of these articles reported PERG amplitude reduction in glaucoma without sizable effects on latency. The one exception is a study by van den Berg et al, 74 who did not find a correlation between visual field loss and PERG amplitude, which can in hindsight be understood as a consequence of the experimental design applied. To reduce interindividual variability, the authors used the fellow eyes as reference.…”

Section: History Of Perg In Glaucomamentioning

confidence: 93%

Update on the Pattern Electroretinogram in Glaucoma

Bach¹,

Hoffmann²

2008

Optometry and Vision Science

136

113

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“…1981), various studies have evaluated the quantitative correlation between the PERG measurements and the perimetric thresholds in the glaucomatous pathology. Early studies, which reported a total absence of correlation (Van den Berg et al. 1986), have not found confirmation in subsequent studies using more sensitive techniques for PERG recording.…”

Section: Introductionmentioning

confidence: 93%

Pattern electroretinogram losses underlying perimetric losses in early glaucoma

Scullica

Falsini

Salgarello

et al. 2002

Acta Ophthalmologica Scandinavica

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In 2001, for the first time in its life, the AISG is holding its Annual Meeting far away from its traditional venue, i.e. Rapallo.The explanation for this decision on the part of its Directive Council, approved, moreover, enthusiastically, by the great majority of its members, lies, in my opinion, in two good reasons: 1 the concomitant IGS with the weight of its programme and the number of participants, as well as the outstanding names present; 2 the attractive beauty of this famous city of Prague, so full of history and charming spots.Our idea has been very much appreciated by our Greek colleagues, who have decided to join us in this initiative, which, on the other hand, has been supported right from the beginning as well by the organizers of IGS, Prof Melamed and Prof Schumann. To both of them go our sincere thanks for their welcome and collaboration.Let us think of it this way, however, that a third good reason for joining our forces may lie in the desire not only to exchange ideas and knowledge, but to meet friends who, for many reasons of life, we see all too rarely and with whom it is so nice to spend some time in a pleasant atmosphere speaking of many topics not necessarily only of ophthalmology.Also for this reason, let us succeed in respecting the times of the programme so as to have more time for enjoying ourselves. 7Prague opening remarks Partly as a result of my participation as moderator in the 1999 American Academy of Ophthalmology Glaucoma Subspecialty Day Symposium on Normal Tension Glaucoma, I have been requested to present an overview on this topic. Having made liberal use of materials provided by each of the speakers in the symposium, I wish to thank Drs Brian Lee, David Greenfield and Roger Hitchings and acknowledge their contributions. This presentation will be divided into the following four sections:I. The misnomer of normal tension glaucoma (NTG). II. Potentially contributing factors in the pathogenesis of glaucoma and their relevance to normal tension glaucoma. III. Potentially differentiating characteristics between glaucoma with normal IOP and glaucoma with elevated intraocular pressure (IOP). IV. Lessons learned from the Normal Tension Glaucoma Study. I. The misnomer of normal tension glaucoma (NTG)There is considerable controversy on whether normal tension glaucoma represents a distinct entity or is simply primary openangle glaucoma (POAG) with IOP within the normal range. Because IOP is a continuous variable with no definite dividing line between normal and abnormal, many authorities are questioning whether the term normal tension glaucoma should be abandoned. Normal tension glaucoma is typically defined as a glaucomatous optic neuropathy despite IOP consistently below 21 mmHg. The question must therefore be asked, 'What's so special about 21 mmHg?' Answering that question requires a review of Leydhecker's landmark investigation of 1958 wherein the IOPs of 20 000 eyes were obtained with Schiotz tonometry (Leydhecker et al. 1959). The mean IOP was found to be 15.5 mmHg with a standar...

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Pattern ERG and glaucomatous visual field defects

Cited by 34 publications

References 18 publications

Relationship Between Pattern Electroretinogram, Standard Automated Perimetry, and Optic Nerve Structural Assessments

Relationship Between Pattern Electroretinogram, Standard Automated Perimetry, and Optic Nerve Structural Assessments

Update on the Pattern Electroretinogram in Glaucoma

Pattern electroretinogram losses underlying perimetric losses in early glaucoma

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