Pattern electroretinogram in multiple sclerosis.

Serra, Gian Pietro; Carreras, M; Tugnoli, V.; Manca, M.; Cristofori, Marco

doi:10.1136/jnnp.47.8.879

Cited by 22 publications

(8 citation statements)

References 9 publications

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“…PERG amplitudes were increased and latencies were longer when body temperature was reduced in the patient group, but there was no change in the response of normal subjects. This suggests in contrast to the results of Serra et al (1984) that PERG can reflect dysfunction in surviving cells affected by demyelination before atrophy occurs.…”

Section: Optic Neuritiscontrasting

confidence: 96%

A review of the clinical applications of the pattern electroretinogram

Hull

Thompson

1989

Ophthalmic Physiologic Optic

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The pattern electroretinogram (PERG) has recently been introduced as a clinical procedure. It has been thought by many to represent activity of the retinal ganglion cells, although this is still a matter of contention. The exciting prospect of a selective test of ganglion cell function led to the application of the PERG in a variety of ophthalmological conditions. In the course of these investigations the PERG was found to be diminished in cases of maculopathy, optic atrophy, optic neuritis, toxic optic neuropathy, neurotransmitter disorders, glaucoma and ocular hypertension and in retinal vascular disorders such as diabetes. It was also affected in some cases of amblyopia. This paper briefly describes the techniques used to record the PERG and reviews current literature pertaining to its clinical application.

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Section: Optic Neuritiscontrasting

confidence: 96%

A review of the clinical applications of the pattern electroretinogram

Hull

Thompson

1989

Ophthalmic Physiologic Optic

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“…Most of these investigations, employing only one or two spatial frequencies (or check sizes), have reported significant PERG abnormalities in a variable proportion of cases [18,[22][23][24][25][26][27]. Some authors [28,29] have evaluated the steady-state PERG in optic neuritis for a range of spatial frequencies and reported losses mainly in the medium to low spatial frequency range.…”

Section: Discussionmentioning

confidence: 99%

Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis

et al. 1992

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Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.

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“…Since the first report on the ganglion cell layer origin o f the pattern electroretinogram (PERG) [1], numerous reports have demon strated reduced PERG amplitudes in various optic nerve diseases [2][3][4][5][6][7][8], especially in glau coma [9][10][11][12][13][14][15][16]. In these pioneering studies, however, the PERGs were recorded at rela tively high contrast and/or high mean lumi tion o f the PERG amplitudes even in healthy eyes (see Results).…”

Section: Introductionmentioning

confidence: 99%

Delay of Pattern Electroretinogram Peaks and Its Correlation to Contrast Threshold for Motion Perception in Glaucoma

Komata

Shirao²,

Watanabe³

et al. 1995

Ophthalmic Res

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Peak latencies of pattern electroretinogram (PERG) were compared between glaucomatous eyes and non-glaucomatous eyes. Contrast threshold for motion pecpetion (CTMP) was also measured with a new device in addition to routine static contrast sensitivity, static visual field and visual acuity. In the present recording, configurations for PERG, i.e. low reversal rate, low mean luminance and presence of background illumination, the PERG peak and trough (P₁ and N₂, respectively) hatencies, were significantly prolonged in the glaucomatous eyes. Although both of the two PERG latencies were strongly correlated with the CTMP, only the P₁ peak latency was strongly correlated with the perimetric indices. These results suggest that the P₁ and N₂ latencies reflect different aspects of signal processing in the retina, especially for moving targets.

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Pattern electroretinogram in multiple sclerosis.

Cited by 22 publications

References 9 publications

A review of the clinical applications of the pattern electroretinogram

A review of the clinical applications of the pattern electroretinogram

Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis

Delay of Pattern Electroretinogram Peaks and Its Correlation to Contrast Threshold for Motion Perception in Glaucoma

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