Pattern and predictors of dyslipidemia in patients with type 2 diabetes mellitus

Karim, Md Nazmul; Ahmed, Kazi Rumana; Bukht, Mohammad Sadaat; Akter, Jesmin; Chowdhury, Hasina Akhter; Hossain, Sharmin; Anwar, Nazneen; Selim, Shahjada; Chowdhury, Shahabul Huda; Hossain, Fawzia; Ali, Liaquat

doi:10.1016/j.dsx.2013.02.011

Cited by 24 publications

(27 citation statements)

References 38 publications

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“…Males had significantly higher prevalence of high LDL-C, high non-HDL-C, high ApoB and mixed dyslipidemia than females, while other lipid parameters were similar. This is in agreement with previous reports from Nepal and elsewhere [20, 35, 36]. We found age specific increase in prevalence of dyslipidemia only in males, with females showing stable or decreasing prevalence with age.…”

Section: Discussionsupporting

confidence: 94%

“…Moreover, prevalence of low HDL-C and high TC/HDL-C ratio was also higher in patients with longer duration of diabetes. These findings are in agreement with the findings of many other studies conducted among diabetic patients in other populations [35, 39]. Type 2 diabetes is often associated with the cluster of several other risk factors of CVD such as older age, insulin resistance, obesity, hypertension, poor glycemic status, microalbuminuria, alterations in inflammatory, coagulation and thrombolytic markers in addition to the atherogenic dyslipidemia [40, 41].…”

Section: Discussionsupporting

confidence: 91%

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Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

et al. 2017

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BackgroundAtherogenic dyslipidemia is an important modifiable risk factor for cardiovascular disease among patients of type 2 diabetes mellitus. Timely detection and characterization of this condition help clinicians estimate future risk of cardiovascular disease and take appropriate preventive measures. The aim of this study was to determine the prevalence, pattern and predictors of dyslipidemia in a cohort of Nepalese patients with type 2 diabetes.ResultsWe found mixed dyslipidemia as the most prevalent (88.1%) and isolated dyslipidemia (10.1%) as the least prevalent forms of dyslipidemia in our patients. The most prevalent form of single dyslipidemia was high LDL-C (73.8%) and combined dyslipidemia was high TG, high LDL-C and low HDL-C (44.7%). Prevalence of all single and mixed dyslipidemia was higher in patients with poor glycemic control and hypertension. The glycemic status of patients correlated with their fasting serum lipid profile. Dyslipidemia was associated mainly with male gender, poor glycemic control and hypertension.ConclusionsAtherogenic dyslipidemia is associated mainly with male gender, poor glycemic control and hypertension. It is highly prevalent in Nepalese patients with type 2 diabetes. Urgent lifestyle modification, sustained glycemic control and aggressive lipid lowering treatment plans are necessary to minimize the future risk of cardiovascular disease in this population.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-017-2465-4) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

et al. 2017

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“…However, in diabetic state insulin deficiency causes inactivation of lipoprotein lipase, resulting in hypertriglyceridemia and hypercholesterolemia [32]. Furthermore, in the diabetic state the secretion of very low-density lipoprotein cholesterol (VLDL) is stimulated by triglycerides and such increase in very low-density lipoprotein cholesterol particles increases the LDL-C particles and reduces the HDL-C level [33]. In our study, the altered serum lipid profile was found in diabetic rats.…”

Section: Discussionmentioning

confidence: 49%

Antidiabetic Effect of Thymus Satureioides Aqueous Extract in Streptozotocin-Induced Diabetic Rats

Kabbaoui

Chda

Mejrhit

et al. 2016

Int J Pharm Pharm Sci

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Objective:The aerial parts of Thymus satureioides have been traditionally used to treat diabetes mellitus and its complications in Morocco. The aim of the present study was to investigate the antidiabetic and antihyperlipidemic effects of the aqueous extract of Thymus satureioides aerial parts in streptozotocin (STZ) induced diabetic rats. Methods:Experimental diabetes was induced in overnight fasted rats by intraperitoneal injection of streptozotocin (45 mg/kg). Diabetic rats were orally administered with aqueous extract of Thymus satureioides (500 mg/kg b.w.) for 28 d. Glibenclamide (2 mg/kg), a standard antidiabetic drug, was used as a positive control drug. Body weight and fasting blood glucose (FGB) were measured every week. Oral glucose tolerance, change in lipid parameters, urea, creatinine, aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) levels of diabetic rats were evaluated at the end of the treatment.Results: Administration of Thymus satureioides aqueous extract to diabetic rats for 28 d reduced their fasting blood glucose levels significantly compared to the diabetic control rats. The extract improved body weight and glucose tolerance in diabetic rats. The antihyperlipidemic assessment of the extract revealed a decrease in plasma total cholesterol, triglycerides, LDL levels and an increase in HDL level in the plasma of treated diabetic rats. Furthermore, the biochemical liver and kidney functional tests have shown that serum biomarkers of liver and renal dysfunction were significantly reduced in treated diabetic rats. Conclusion:The present findings suggest that Thymus satureioides extract has both antidiabetic and antihyperlipidemic effects in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.

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“…Research on working-age Japanese males showed that there is a link between hypertension and increased levels of TC, LDL, and non-HDL [28]. Another study conducted in Bangladesh using T2DM patients showed a link between hypertension and an increased risk of abnormal TC levels by 1.50 and HDL by 1.67 times higher [29]. Poor glycemic control can increase the risk of abnormalities 2.176 times higher than in subjects with good glycemic control.…”

Section: Discussionmentioning

confidence: 97%

Distribution Patterns and Risk Factors of Dyslipidemia in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Bogor, Indonesia

Pradipta

Wibowo²,

Harbuwono³

et al. 2020

Int J App Pharm

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Objective: Type 2 diabetes mellitus (T2DM) patients tend to have abnormal lipid profiles, explaining the association between elevated cholesterol andtriglyceride levels in diabetic patients and coronary heart disease. This study aims to evaluate how the common risk factors for dyslipidemia affectthe lipid profile of diabetic patients and to determine which factors can be used as predictors for the occurrence of dyslipidemia in T2DM patients.Methods: A total of 238 diabetic patients (63 male and 175 female; age: 31–70 years) were enrolled in this cross-sectional study. All of them hadundergone regular examinations in cohort studies on risk factors for non-communicable diseases conducted by the Ministry of Health in Bogorbetween December 2017 and January 2018.Results: The result found that age differences did not affect lipid profile levels, and the females had higher mean values of body mass index (p<0.001),total cholesterol (TC) (p<0.05), and high-density lipoprotein (HDL) (p<0.001) than the males. The most common occurrences of dyslipidemia werehigh TC level (57.1%), followed by high low-density lipoprotein (LDL) level (47.1%), high triglyceride level (37.4%), and low HDL level (16.4%). Beingoverweight was found to be the best predictor of dyslipidemia.Conclusion: The results of this study suggest that in T2DM patients, sex affects TC and HDL levels, whereas age does not exert a significant effect onthe lipid profiles. In addition, poor glycemic control, hypertension, and obesity may serve as predictors of dyslipidemia in T2DM patients.

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Pattern and predictors of dyslipidemia in patients with type 2 diabetes mellitus

Cited by 24 publications

References 38 publications

Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

Antidiabetic Effect of Thymus Satureioides Aqueous Extract in Streptozotocin-Induced Diabetic Rats

Distribution Patterns and Risk Factors of Dyslipidemia in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Bogor, Indonesia

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