Pattern and Outcome of Acute Poisoning Cases in a Tertiary Care Hospital in Eastern Nepal

Sigdel, Deepak; Jha, Sarbesh Kumar; Kathet, Ragin; Mainal, Uttar Kumar; Pokharel, Roshan; Dwivedi, Atul Kumar

doi:10.21276/ijcmr.2019.6.4.53

Cited by 5 publications

(6 citation statements)

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“…24 In this study, the most common poisoning was due to Organophosphate similar to studies conducted in Eastern Nepal, Kenya, and Gondar. [25][26][27] This may be due to the easy availability of this poisoning agent in the agricultural community and inadequate knowledge to support their safe residential use. 28 Unlikely the current study, studies done in Debretabor General Hospital, Addis Ababa, South Africa, and Uganda reported that rat poisoning, drug poisoning, and household chemical poisoning were accounted for the highest numbers of cases, respectively.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

et al. 2022

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Introduction: Acute poisoning causes morbidity and mortality worldwide. There is scarce of information on acute poisoning in the study area. Objective: To assess treatment outcome and the associated factors among patients admitted with acute poisoning at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia. Methods: A cross-sectional study was conducted. All acutely poisoned patients who had been admitted at the emergency department of Hiwot Fana Comprehensive Specialized Hospital from 1 January 2016 to 31 December 2020 who fulfilled the inclusion criteria of the study were included. Data were collected by review of medical records. Poor treatment outcome of acute poisoning was defined as the acutely poisoned patient was died, or survived with disability. Multivariate logistic regression analysis was used to determine factors associated with the outcome of acute poisoning. Result: A total of 175 patient’s medical records were reviewed. Of these, 150 patient’s medical records had complete information and were included in the final analysis. The majority of participants 89 (59.3%) were in the age group of 19–37 years. More than half of the participants 86 (57.3%) were females. Organophosphate was the most poisoning agent encountered in 62 cases. Acetaminophen was the predominant drug poisoning agent encountered in 10 participants. Among 30 patients managed with antidote, 18 patients were treated with atropine for organophosphate poisoning. Of all the poisoning cases admitted during the study period, 16.7% died. Participants who were poisoned by themselves were 2.4 times more likely to have poor treatment outcomes than those who were poisoned accidentally: 2.44 (95% confidence interval: 1.10–5.42). The odd of having poor treatment outcome in participants who were poisoned by drugs was 2.13 more likely: 2.13 (95% confidence interval: 1.21–3.32). Conclusion: Organophosphate was the predominant cause of acute poisoning encountered in 62 cases. The modes of poisoning and drug poisoning were significant risk factors associated with poor treatment outcomes of acute poisoning.

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Section: Discussionmentioning

confidence: 99%

Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

et al. 2022

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“…The current study declared that drug poisoning was more prevalent cause of poisoning (59.5%) compared to non-drug poisoning (40.5%), bearing a great resemblance to the data issued by Wijegoonawardene et al (2015) and Hegazy and Elfiky (2016) where drugs were responsible for poisoning in 63.6% and 52.9% of their studied patients, respectively. On the other hand, Sigdel et al (2019) recorded non-drug poisoning, mainly by organophosphorous insecticides in 68.4% of their poisoned patients in Nepal.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Severity of Poisoning Exposures among Patients Presented to Poison Control Center, Ain Shams University Hospitals, Egypt during 2019

Abdelhamid

2021

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Poisoning exposure continues to be an important public health concern in many developing countries and a major cause of morbidity and mortality in Egypt. The information released by the Poison Control Center of Ain Shams University Hospitals (PCC-ASUH) is mostly a trigger for increasing hazards challenging the community. Aim: To evaluate severity of poisoning exposures among patients presented to PCC-ASUH during year 2019. Methods: A retrospective study involved patients presented to the PCC-ASUH with history of poisoning during 2019. Results: This study included 21,492 patients. The majority of poisoning incidents were at the age group of 15 -25 years (34%) and females outnumbered males (54.8% versus 45.2%). Route of poisoning was mostly oral (89.1%). Most poison exposures were suicidal (51.5%). Drug poisoning constituted the majority of cases (59.5%). Centrally acting drugs were the commonest drugs (18%) and household chemicals were the commonly used poisons (13.4%). Poisoning severity score was mild in 79.4% of cases, moderate in 14.4% and severe in 6.2% of cases. Mortality rate was 0.66%. Higher PSS was associated with prolonged hospital stay and death. Conclusion:Poisoning is more common in young and middle-aged people. Ingestion was the main route of poisoning and suicidal poisoning predominated. Corrosives and detergents were the most commonly involved toxic substances while centrally acting drugs topped the list of drug poisoning. Higher PSS was associated with prolonged hospital stay and death. Recommendations:Poisoning severity score is a simple tool for better poisoning assessment. Strict regulations are needed to control medication marketing.

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“…4,7 The clinical profile and pattern of poisoning are not uniform even in various parts of the same country because of variation in the factors such as geography, accessibility and availability of poison, socioeconomic status, cultural and religious influence. 5,8,9 In our study, a total of 150 cases of poisoning were admitted to our hospital which was 14.98% of total ICU cases (1001). We found higher incidence of poisoning in females (female to male ratio of 1.38:1), which is similar to that shown by Baral In…”

Section: Discussionmentioning

confidence: 80%

“…(1.48:1), Sigdel et al8 (1.13:1), Lee et al4 (1.21:1), Karki et al6 (1.7:1), Rajbanshi et al1 (1.65:1), Woyessa et al9 (1.45:1), Marahatta et al10 (1.34:1), Singh et al11 (1.3:1), Mandal et al12 (1.9:1), Khadka et al13 (1.09:1). However, studies by Joshi et al5 and Thapa et al 14 has shown male predominance.…”

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confidence: 98%

Clinical Profile of Patients With Poisoning Admitted to Tertiary Care Centre of Nepal

Jahan,

Singh,

Tiwari

et al. 2023

JCMC

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Background: Acute poisoning is one of major medical emergencies and a common cause of admission and death in hospitals in Nepal. In our country, agrochemicals including pesticides like Organophosphorus, organochlorine, zinc and aluminium phosphide are most common causative agents used for intentional or accidental poisoning. The study was aimed to assess clinical profile of patients with poisoning admitted to tertiary care centre of Nepal. Methods: This retrospective study was conducted to see clinical profile of patients diagnosed with poisoning in Chitwan Medical College Teaching Hospital for 1 year period from February, 2022 to January, 2023. Data were collected from hospital medical records and Midas software. Data analysis was performed using Statistical package for Social Sciences version 21 and data are presented as frequency and percentage. Results: A total of 150 cases of poisoning presented to our hospital during the one-year period. Among them, 42% patients were males and 58% females (1.38:1). Most of them (34%) belonged to age group of 21-30 years. Majority of the cases were suicidal (86%). Organophosphorus was the most common poison (36.66%), followed by rat poison-(12.66%). About 44% patients went on Leave Against Medical Advice, 28% on Discharge On Request, 23% patients were discharged with full recovery, whereas mortality with treatment was 5%. Conclusions: Poisoning is more prevalent in females and younger age group. The most common agent is Organophosphorus followed by rat poison. Self-poisoning with suicidal intent is the most common mode of poisoning. Mortality in this study was 5.33% which was more among Organophosphorus poisoning.

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Pattern and Outcome of Acute Poisoning Cases in a Tertiary Care Hospital in Eastern Nepal

Cited by 5 publications

References 4 publications

Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

Treatment outcome and associated factors among patients admitted with acute poisoning in a tertiary hospital in Eastern Ethiopia: A cross-sectional study

Evaluation of Severity of Poisoning Exposures among Patients Presented to Poison Control Center, Ain Shams University Hospitals, Egypt during 2019

Clinical Profile of Patients With Poisoning Admitted to Tertiary Care Centre of Nepal

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