Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
-The intercellular adhesion molecule is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Serum and cerebrospinal fluid (CSF) soluble intercellular adhesion molecule 1 (sICAM-1) from normal control children as well as from children with Guillain-Barré syndrome (GBS), with Coxsackie A9 virus meningoencephalitis and with Streptococcus pneumoniae meningoencephalitis were studied. sICAM-1 was quantified using an immunoenzimatic assay and albumin using the immunodiffusion technique in both biological fluids. Increased sICAM-1 values in CSF in patients with GBS correspond to an increase of the albumin CSF/serum quotient. In contrast, in inflammatory diseases like S. pneumoniae and Coxsackie A9 virus meningoencephalitis an increased brain-derived fraction was observed. In particular cases these values are 60-65% and 70-75% respectively. The results indicate an additional synthesis of sICAM-1 in subarachnoidal space during central nervous system (CNS) inflammatory process. An important role of sICAM-1 in the transmigration of different cell types into CSF during CNS inflammation in children with S. pneumoniae and Coxsackie A9 meningoencephalitis may be suggested.Key wordS: cerebrospinal fluid, sICAM-1, Coxsackie A9, Streptococcus pneumoniae, children.Síntesis intratecal de sICAM-1 y liberación durante la fase aguda en niños con meningoencefalitis por Coxsackie A9 y S. pneumoniae Resumen -La molécula de adhesión intercelular es una glicoproteína que pertenece a la superfamilia de las inmunoglobulinas. Se estudiaron los niveles de molécula de adhesión intercelular tipo 1 soluble (sICAM-1) en suero y líquido cefalorraquídeo (LCr) de niños con meningoencefalitis por Streptococcus pneumoniae y por Coxsackie A9 al igual que en niños con sindrome de Guillain-Barré (SGB). sICAM-1 fue cuantificado por ensayo inmunoenzimático y la albúmina por inmunodifusión en ambos líquidos biológicos. Los valores incrementados de sICAM-1 en LCr en los pacientes con GBS corresponden a valores aumentados de razón LCr/suero de albúmina. en contraste, en las enfermedades inflamatorias como las meningoencefalitis por S. pneumoniae y por Coxsackie A9 se observa un incremento en la fracción derivada del cerebro. en casos particulares los valores se incrementan hasta un 60-65% y 70-75% respectivamente. Los resultados indican una síntesis adicional de sICAM-1 en el espacio subaracnoideo durante el proceso inflamatorio del sistema nervioso central (SNC). esto puede sugerir un importante papel del sICAM-1 en la transmigración de diferentes tipos celulares en el LCr durante la inflamación del SNC en niños con meningoencefalitis por S pneumoniae y coxsackie A9.PALABrAS-CLAve: líquido cefalorraquídeo, sICAM-1, Coxsackie A9, Streptococcus pneumoniae, niños.
-The intercellular adhesion molecule is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Serum and cerebrospinal fluid (CSF) soluble intercellular adhesion molecule 1 (sICAM-1) from normal control children as well as from children with Guillain-Barré syndrome (GBS), with Coxsackie A9 virus meningoencephalitis and with Streptococcus pneumoniae meningoencephalitis were studied. sICAM-1 was quantified using an immunoenzimatic assay and albumin using the immunodiffusion technique in both biological fluids. Increased sICAM-1 values in CSF in patients with GBS correspond to an increase of the albumin CSF/serum quotient. In contrast, in inflammatory diseases like S. pneumoniae and Coxsackie A9 virus meningoencephalitis an increased brain-derived fraction was observed. In particular cases these values are 60-65% and 70-75% respectively. The results indicate an additional synthesis of sICAM-1 in subarachnoidal space during central nervous system (CNS) inflammatory process. An important role of sICAM-1 in the transmigration of different cell types into CSF during CNS inflammation in children with S. pneumoniae and Coxsackie A9 meningoencephalitis may be suggested.Key wordS: cerebrospinal fluid, sICAM-1, Coxsackie A9, Streptococcus pneumoniae, children.Síntesis intratecal de sICAM-1 y liberación durante la fase aguda en niños con meningoencefalitis por Coxsackie A9 y S. pneumoniae Resumen -La molécula de adhesión intercelular es una glicoproteína que pertenece a la superfamilia de las inmunoglobulinas. Se estudiaron los niveles de molécula de adhesión intercelular tipo 1 soluble (sICAM-1) en suero y líquido cefalorraquídeo (LCr) de niños con meningoencefalitis por Streptococcus pneumoniae y por Coxsackie A9 al igual que en niños con sindrome de Guillain-Barré (SGB). sICAM-1 fue cuantificado por ensayo inmunoenzimático y la albúmina por inmunodifusión en ambos líquidos biológicos. Los valores incrementados de sICAM-1 en LCr en los pacientes con GBS corresponden a valores aumentados de razón LCr/suero de albúmina. en contraste, en las enfermedades inflamatorias como las meningoencefalitis por S. pneumoniae y por Coxsackie A9 se observa un incremento en la fracción derivada del cerebro. en casos particulares los valores se incrementan hasta un 60-65% y 70-75% respectivamente. Los resultados indican una síntesis adicional de sICAM-1 en el espacio subaracnoideo durante el proceso inflamatorio del sistema nervioso central (SNC). esto puede sugerir un importante papel del sICAM-1 en la transmigración de diferentes tipos celulares en el LCr durante la inflamación del SNC en niños con meningoencefalitis por S pneumoniae y coxsackie A9.PALABrAS-CLAve: líquido cefalorraquídeo, sICAM-1, Coxsackie A9, Streptococcus pneumoniae, niños.
The unstable epidemiologic situation regarding enterovirus infection against the background of strong international interaction increases the risk of importation of the pathogens in the Russian Federation. The aim of the research was to evaluate the epidemiologic risks of importation of the enterovirus infection in the Khabarovsk region. Molecular epidemiologic analysis was performed for 481 samples obtained from sewage as well as clinical material from patients with enterovirus infection and exposed persons. The phylogenetic reconstruction was performed according with the Bayesian modeling approach. The molecular epidemiologic research has shown that in the Khabarovsk region enteroviruses of group B (Coxsackievirus B4, B5, ECHO 6, ECHO 9, ECHO 30) were dominant. The molecular-clock analysis used in order to evaluate evolutionary distances highlighted the epidemiologic connection between the cases of enterovirus infection diagnosed in the Khabarovsk region and other regions of the Russian Federation, China, Netherlands and India. The study revealed a potential risk of introduction of the following enteroviruses in the Khabarovsk region - Coxsackievirus B4, B5, ECHO 6, ECHO 9, ECHO 30 from countries of the Asian-Pacific Region, Europe and other regions of the Russian Federation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.