Patofisiologi Spinal Cord Injury

Abstract

Spinal cord injury (SCI) dapat mengakibatkan defisit motorik, sensorik, dan autonom yang substansial, bahkan permanen. Saat spinal cord mengalami trauma, trauma awal akan menyebabkan kerusakan langsung; seiring waktu, proses inflamasi akut ditambah astrogliosis berkontribusi terhadap cedera sekunder. Berbagai modalitas evaluasi dan terapi SCI masih belum sepenuhnya berhasil memperbaiki fungsi neurologis. Hal ini diduga akibat kompleksitas patofisiologi SCI. Spinal cord injury (SCI) can cause substantial motor, sensory, and autonomic deficits or even permanent loss of neurological function. The initial trauma causes direct damage to the spinal cord; the acute inflammatory process coupled with astrogliosis contributes to secondary injury. Various evaluation and treatment modalities for SCI are still mostly unsuccessful in improving neurological function. This is may be due to the complexity of the pathophysiology of SCI.