Patients with Very Early-onset Systemic Juvenile Idiopathic Arthritis Exhibit More Inflammatory Features and a Worse Outcome

Abstract

Patients with EO exhibited a more aggressive and destructive disease course than patients with LO SJIA.

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010–2013

“…Demographic features of the CARRA sJIA cohort are similar to previously described smaller cohorts in age at diagnosis, sex, and time to diagnosis 20,21,22 . Demographic features of the CARRA sJIA cohort are similar to previously described smaller cohorts in age at diagnosis, sex, and time to diagnosis 20,21,22 .…”

Review: Is There a Window of Opportunity for Treatment of Systemic Juvenile Idiopathic Arthritis?

“…Systemic JIA represents ∼5–15% of arthritis that begins during childhood. Like some other forms of JIA, the epidemiology of systemic JIA features an early incidence peak between 1 and 5 years of age, although the disease may arise at any time during childhood (). A similar disease occurs in adults (adult‐onset Still's disease [AOSD]).…”

Anakinra in Systemic Juvenile Idiopathic Arthritis: A Single-center Experience

“…However, this hypothesis was not formally investigated. Indeed, early-onset sJIA has been described as significantly more severe, particularly if onset occurs before 18 months of age 17 . It is also noteworthy that in the study by Gattorno, et al 15 , complete responders had a higher median age than nonresponders (8.3 yrs vs 4.6 yrs, respectively).…”