Patients with ventromedial prefrontal lesions show an implicit approach bias to angry faces

Abstract

1Damage to the orbitofrontal cortex (OFC) can cause maladaptive social behavior, but the cognitive 2 processes underlying these behavioral changes are still uncertain. Here, we tested whether patients with 3 acquired OFC lesions show altered approach-avoidance tendencies to emotional facial expressions. 4Thirteen patients with focal OFC lesions and 31 age-and gender-matched healthy controls performed an 5 implicit approach-avoidance task in which they either pushed or pulled a joystick depending on stimulus 6 color. While controls avoided angry faces, OFC patients displayed an incongruent response pattern 7 characterized by both increased approach and reduced avoidance of angry facial expressions. The 8 approach bias was stronger in patients with higher self-reported impulsivity and disinhibition, and in those 9 with larger lesions. Moreover, patients committed more errors in the task, which in turn was correlated with 10 self-rated clinical impairment. We further used linear ballistic accumulator modelling to investigate latent 11 parameters underlying approach-avoidance decisions. Controls displayed negative drift rates when 12 approaching angry faces, whereas OFC lesions abolished this bias. In addition, OFC patients had weaker 13 response drifts than controls during angry face avoidance. Finally, patients showed generally reduced 14 variability in drift rates and shorter non-decision times, indicating impulsive and rigid decision-making. In 15 sum, our findings suggest that OFC damage alters the pace of evidence accumulation in response to threat 16 signals, eliminating a default, protective avoidant bias and facilitating dysfunctional approach behavior. 17 18