Patients with primary cutaneous lymphoma are at risk for severe COVID‐19. Data from the Spanish Primary Cutaneous Lymphoma Registry

Sánchez-Velázquez, Alba; Bauer-Alonso, Andrea; Estrach, Teresa; García-Muret, Pilar; Haya, Laura; Peñate, Yeray; Acebo, Elvira; Misa, Ricardo; Blanes, Mar; Suh‐Oh, Hae Jin; Izu, R.; Silva-Díaz, E.; Sarriugarte, J; Román-Curto, Concépción; Botella‐Estrada, Rafael; Mateu-Puchades, Almudena; Prieto‐Torres, Lucía; Morillas, V; Morillo, Mercedes; Sánchez-Caminero, P.; Calzado, L.; Pérez‐Ferriols, A.; Pulido‐Pérez, Ana; Dominguez, J.D.; Navedo, M.; Muniesa, Cristina; Combalía, Andrea; Arroyo‐Andrés, Jorge; Descalzo, M.Á.; García‐Doval, I.; Ortiz‐Romero, Pablo L.

doi:10.1111/jdv.17430

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…The apparent resemblance between the genetic features characteristics of the more severe forms of COVID-19 and those implicated in the NHL pathogenesis matches the link between previous viral and microbial infections, including HIV infection, and NHL risk, whether through immunosuppression or other mechanisms [20,21]. In agreement with the hypothesis of shared pathways, a few reports have described an increase in COVID-19 incidence and severity among patients with a diagnosis of primary cutaneous lymphoma (PCL) [22,23] and haematological disease in general [24,25] but not among cancer patients, including lymphoma patients [26]. However, patients with specific NHL subtypes may differ in terms of vulnerability to SARS-CoV-2 infection; it is unclear whether treatment-induced immunosuppression [27,28] and the generic low-rate seroconversion in onco-haematological patients [29] would be exhaustive explanations for such differences.…”

Section: Introductionsupporting

confidence: 55%

COVID-19 and non-Hodgkin’s lymphoma: A common susceptibility pattern?

Sara

Minelli

Broccia³

et al. 2023

PLoS ONE

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Objective To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence. Design Ecological study design. Setting Sardinia, Italy. Participants We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population. Main outcomes and measures We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974–2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates. Results The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL. Conclusion This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.

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Section: Introductionsupporting

confidence: 55%

COVID-19 and non-Hodgkin’s lymphoma: A common susceptibility pattern?

Sara

Minelli

Broccia³

et al. 2023

PLoS ONE

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“…Consistently with the apparently similar genetic susceptibility features, numerous studies have confirmed a strong link between previous viral and microbial infections, including HIV infection, and NHL risk, whether through immunosuppression or other mechanisms [19,20]. On the other side, a few reports have described an increase in COVID-19 incidence and severity among patients with a diagnosis of primary cutaneous lymphoma (PCL) [21,22] and haematological disease in general [23,24], but not among patients suffering from any cancer, including lymphoma patients [25]. However, NHL subtypes may differ in terms of vulnerability to SARS-CoV-2 infection.…”

Section: Introductionmentioning

confidence: 85%

COVID-19 and non-Hodgkin’s lymphoma: a common susceptibility pattern?

Sara

Minelli

Broccia³

et al. 2022

Preprint

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Objective To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence. Design Ecological study design. Setting Sardinia, Italy. Participants We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population. Main outcomes and measures We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974-2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates. Results The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL. Conclusion This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.

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“…Some studies have evaluated risk factors for severe COVID-19 among patients with MF/SS, which included lymphopenia, chronic organ failure, Sezary syndrome, or active aggressive disease [11]. Moreover, initial reports indicate that clinical outcomes of patients with MF/SS that were infected with COVID-19 were not significantly different from the general population [12, 13]. However, most of these studies were conducted at the beginning of the pandemic and included only the SARS-CoV-2 Alpha variant and non-vaccinated patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome

Yurkovski¹,

Rokach²,

Melamed³

et al. 2023

Acta Haematol

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Introduction: Haemato-oncologic patients are more susceptible to severe infections with SARS-CoV-2. We aimed to assess the clinical outcomes of SARS-CoV-2 infection among patients with Mycosis Fungoides and Sezary Syndrome (MF/SS). Methods: The data was retrieved from anonymized electronic medical records of Maccabi Healthcare Services (MHS), the second-largest healthcare organization in Israel. Patients diagnosed with MF/SS were included in the study. COVID-19 PCR, test results together with socio-demographic and clinical data were extracted and analyzed to evaluate the association of COVID-19 with clinical outcomes. Results: In the period of 2020-2022, 1472 MF/SS patients were included in the study. Among them, 768 (52%) had SARS-CoV-2 infection. The hospitalization rate was 2.9% and infection by the Delta variant was associated with the highest hospitalization rate (7.7%). The hospitalization rate was lower among fully vaccinated patients (p=0.032), but higher for patients older than 65 (p<0.001) and patients with SS (vs. MF) (p<0.001) or COPD (p=0.024) diagnosis. There was a tendency for decreased hospitalization among patients treated with nirmatrelvir + ritonavir within five days of infection, with a 79% risk reduction, although it was not statistically significant (p=0.164). Conclusion: Patients with MF/SS do not necessarily have worse COVID-19 outcomes compared to the general population.

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Patients with primary cutaneous lymphoma are at risk for severe COVID‐19. Data from the Spanish Primary Cutaneous Lymphoma Registry

Abstract: While some papers report an increased risk of COVID‐19 and worse outcomes 1 in oncological patients, others have found no differences 2 . We are not aware of studies assessing risk for COVID‐19 and clinical outcomes of patients with Primary Cutaneous Lymphomas (PCL).

Cited by 8 publications

References 5 publications

COVID-19 and non-Hodgkin’s lymphoma: A common susceptibility pattern?

COVID-19 and non-Hodgkin’s lymphoma: A common susceptibility pattern?

COVID-19 and non-Hodgkin’s lymphoma: a common susceptibility pattern?

Clinical Outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome

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