Patients With Postural Orthostatic Tachycardia Syndrome (POTS) Have A Lower Level Of Fitness Compared To Healthy But Sedentary Females

Shook, Robin P.; Fu, Qi; VanGundy, Tiffany B.; Shibata, Shigeki; Hastings, Jeffrey L.; Conner, Colin; Palmer, M. Dean; Levine, Benjamin D.

doi:10.1249/01.mss.0000273623.86697.99

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, when expressed at the relative workload (percent of VO 2peak ), the heart rate responses are not different between POTS patients and healthy individuals (Figure 2) (Shook et al , 2007). These results suggest that POTS patients have no intrinsic abnormality of heart rate regulation during exercise.…”

Section: Acute Exercise Responses In Potsmentioning

confidence: 94%

Exercise in the postural orthostatic tachycardia syndrome

Levine

2015

Autonomic Neuroscience

Self Cite

View full text Add to dashboard Cite

Patients with the Postural Orthostatic Tachycardia Syndrome (POTS) have orthostatic intolerance, as well as exercise intolerance. Peak oxygen uptake (VO2peak) is generally lower in these patients compared with healthy sedentary individuals, suggesting a lower physical fitness level. During acute exercise, POTS patients have an excessive increase in heart rate and reduced stroke volume for each level of absolute workload; however, when expressed at relative workload (%VO2peak), there is no difference in the heart rate response between patients and healthy individuals. The relationship between cardiac output and VO2 is similar between POTS patients and healthy individuals. Short-term (i.e., 3 months) exercise training increases cardiac size and mass, blood volume, and VO2peak in POTS patients. Exercise performance is improved after training. Specifically, stroke volume is greater and heart rate is lower at any given VO2 during exercise after training versus before training. Peak heart rate is the same but peak stroke volume and cardiac output are greater after training. Heart rate recovery from peak exercise is significantly faster after training, indicating an improvement in autonomic circulatory control. These results suggest that patients with POTS have no intrinsic abnormality of heart rate regulation during exercise. The tachycardia in POTS is due to a reduced stroke volume. Cardiac remodeling and blood volume expansion associated with exercise training increase physical fitness and improve exercise performance in these patients.

show abstract

Section: Acute Exercise Responses In Potsmentioning

confidence: 94%