Patients with mild Alzheimer’s disease produced shorter outgoing saccades when reading sentences

Fernández, Gerardo; Schumacher, Marcela; Castro, Liliana; Orozco, David; Agamennoni, Osvaldo

doi:10.1016/j.psychres.2015.06.028

Cited by 16 publications

(14 citation statements)

References 53 publications

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“…Antisaccade measures [14] and errors in line bisection with background movement [15] were reported to correlate with dementia severity. Reading is also impaired in presumed AD: slowness, more saccade regressions, less words with one fixation, shorter forward saccades and the absence of contextual word predictability effect [16].…”

Section: Eye Movements To Explore Cognition In Presumed Admentioning

confidence: 99%

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What do we Know About Eye Movements in Alzheimer’s Disease? The Past 37 Years and Future Directions

Coubard¹

2016

Biomark. Med.

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Section: Eye Movements To Explore Cognition In Presumed Admentioning

confidence: 99%

“…-Reading: higher saccade regression occurrence, lower one-fixation word occurrence, reduced forward saccade amplitude, lack of contextual word predictability effect [16]? ;…”

Section: Eye Movement and Cognitive Markers In Presumed Admentioning

confidence: 99%

What do we Know About Eye Movements in Alzheimer’s Disease? The Past 37 Years and Future Directions

Coubard¹

2016

Biomark. Med.

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“…Fixations are therefore the end result of complex interactions between features of the explored environment ("bottom up") and the instruction or question to be solved by the explorer ("top down") [3,4,5,6,7,8,9,10]. Behind such eye movement patterns, there are complex cognitive functions such as attention, executive control, and working memory [11,12,13,14,15,9,16,17]. Hence, the investigation of abnormal patterns of eye movement could provide critical information on the influence that some pathologies causing visual impairments, such as Alzheimer Disease (AD), have on these cognitive abilities, and in doing so unveil the source of capacity loss linked to specific processing levels.…”

Section: Introductionmentioning

confidence: 99%

Visual Processing during Short-Term Memory Binding in Mild Alzheimer’s Disease

Fernández

Orozco

Agamennoni

et al. 2018

JAD

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Patients with Alzheimer's disease (AD) typically present with attentional and oculomotor abnormalities that can have an impact on visual processing and associated cognitive functions. Over the last few years, we have witnessed a shift toward the analyses of eye movement behaviors as a means to further our understanding of the pathophysiology of common disorders such as AD. However, little work has been done to unveil the link between eye moment abnormalities and poor performance on cognitive tasks known to be markers for AD patients, such as the short-term memory-binding task. We analyzed eye movement fixation behaviors of thirteen healthy older adults (Controls) and thirteen patients with probable mild AD while they performed the visual short-term memory binding task. The short-term memory binding task asks participants to detect changes across two consecutive arrays of two bicolored object whose features (i.e., colors) have to be remembered separately (i.e., Unbound Colors), or combined within integrated objects (i.e., Bound Colors). Patients with mild AD showed the well-known pattern of selective memory binding impairments. This was accompanied by significant impairments in their eye movements only when they processed Bound Colors. Patients with mild AD remarkably decreased their mean gaze duration during the encoding of color-color bindings. These findings open new windows of research into the pathophysiological mechanisms of memory deficits in AD patients and the link between its phenotypic expressions (i.e., oculomotor and cognitive disorders). We discuss these findings considering current trends regarding clinical assessment, neural correlates, and potential avenues for robust biomarkers.

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“…Since AD is nonreversible, early treatment can improve a patient's life by delaying the full manifestation of the disease. In recent years, the study of eye movement during reading, known as eye-tracking, has proved helpful for performing this task [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Eye movement behavior identification for Alzheimer's disease diagnosis

Biondi¹,

Fernández²,

Castro³

et al. 2018

J. Integr. Neurosci.

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We develop a deep-learning approach to differentiate between the eye movement behavior of people with neurodegenerative diseases during reading compared to healthy control subjects. The subjects with and without Alzheimer's disease read welldefined and previously validated sentences including high-and low-predictable sentences, and proverbs. From these eyetracking data trial-wise information is derived consisting of descriptors that capture the reading behavior of the subjects. With this information a set of denoising sparse-autoencoders are trained and a deep neural network is built using the trained autoencoders and a softmax classifier that identifies subjects with Alzheimer's disease with 89.78% accuracy. The results are very encouraging and show that such models promise to be helpful for understanding the dynamics of eye movement behavior and its relation with underlying neuropsychological processes.

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Patients with mild Alzheimer’s disease produced shorter outgoing saccades when reading sentences

Cited by 16 publications

References 53 publications

What do we Know About Eye Movements in Alzheimer’s Disease? The Past 37 Years and Future Directions

What do we Know About Eye Movements in Alzheimer’s Disease? The Past 37 Years and Future Directions

Visual Processing during Short-Term Memory Binding in Mild Alzheimer’s Disease

Eye movement behavior identification for Alzheimer's disease diagnosis

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