Patients with m2 antibodies: what diagnosis and follow-up are they given?

Byrne, Elizabeth; Katbamna, R; Scott, Colin; Blanshard, C; Marley, Richard; Foster, G.R.

doi:10.1136/gut.2009.190769

Cited by 2 publications

(2 citation statements)

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“…These M2 antibodies have very strong association with present or future diagnosis of primary biliary cirrhosis (PBC). 18 Indeed, laboratory-initiated protocols have also led to PBC diagnosis from finding unexplained high alkaline phosphatase activity, or elevated IgM concentrations. 17 …”

Section: Causes Of Unexpected Laboratory Resultsmentioning

confidence: 99%

<p>The Clinical Approach on Receipt of an Unexpected Laboratory Test Result</p>

Masood¹,

Karim²

2020

IJGM

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Approximately 70% of all healthcare decisions affecting diagnosis and treatment involve the use of tests performed within pathology laboratories. The utilisation of diagnostic laboratory services continues to increase, with growth both in volume of tests requested, as well as in the breadth of test repertoire. Every year in the United Kingdom, approximately 1 billion tests are run in hospital laboratories, equivalent to 14 tests per person. Fifty million tests are requested in primary care. Accordingly, there is an inevitable increase in the number of unexpected laboratory results which clinicians review. This is an important, and potentially time-consuming, issue, which we considered to merit a more detailed discussion. Unexpected laboratory results may be critical or non-critical in nature. They may be absolutely genuine, reflecting a clinical change in the patient’s condition, a differential diagnosis not previously considered, or an additional test specifically added by the laboratory. However, such results may also occur due to a variety of different circumstances, including much more rarely laboratory error. As there is little published evidence or guidance available, herein we discuss aspects of the clinical approach for physicians after receiving an unexpected laboratory test result.

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Section: Causes Of Unexpected Laboratory Resultsmentioning

confidence: 99%

<p>The Clinical Approach on Receipt of an Unexpected Laboratory Test Result</p>

Masood¹,

Karim²

2020

IJGM

View full text Add to dashboard Cite

show abstract

“…We very much appreciate the letter by Byrne et al ,1 and it was of interest for us to learn that even nowadays, that is >40 years after the first description of antimitochondrial antibody (AMA) in primary biliary cirrhosis (PBC) and identification of their target antigen as an inner mitochondrial membrane antigen (later labelled M2),2 3 early PBC is underdiagnosed and underinvestigated and was formally assessed in only ∼40% of anti-M2-positive patients. We therefore agree that a better education of medical practitioners is required in this respect.…”

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confidence: 99%

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Klein

2010

Gut

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Patients with m2 antibodies: what diagnosis and follow-up are they given?

Cited by 2 publications

References 3 publications

<p>The Clinical Approach on Receipt of an Unexpected Laboratory Test Result</p>

<p>The Clinical Approach on Receipt of an Unexpected Laboratory Test Result</p>

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