Patients With Inflammatory Bowel Disease on Treatment Have Lower Rates of Celiac Disease

Alkhayyat, Motasem; Abureesh, Mohammad; Almomani, Ashraf; Saleh, Mohannad Abou; Zmaili, Mohammad; Ouali, Sara El; Mansoor, Emad; Rubio–Tapia, Alberto; Regueiro, Miguel

doi:10.1093/ibd/izab084

Cited by 6 publications

(5 citation statements)

References 52 publications

(64 reference statements)

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“…Limitations of this study include the lack of data on IBD medication and adherence to a gluten-free diet in patients with CeD. In particular, we cannot rule out that steroids and other immunosuppressants or immunomodulatory therapy for IBD can reduce the CeD risk or cause an underdiagnosis of the disease (29,30). We also lacked data on laboratory test results or symptoms, if any, that might have prompted the second diagnosis in patients with pre-existing IBD or CeD.…”

Section: Discussionmentioning

confidence: 99%

Association of Celiac Disease and Inflammatory Bowel Disease: A Nationwide Register-Based Cohort Study

et al. 2022

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To determine the risk of inflammatory bowel disease (IBD) in patients with celiac disease (CeD) (and vice versa) compared with general-population comparators. METHODS:Using Swedish histopathology and healthcare register data, we identified 48,551 patients with CeD and 83,529 with IBD diagnosed in 1969-2016. Each patient was compared with age-and sexmatched general-population comparators (CeD: n 5 240,136; IBD: n 5 408,195). Cox regression estimated hazard ratios (HRs) for IBD in patients with CeD and vice versa. Our main analyses were limited to events beyond the first year of follow-up to reduce potential surveillance bias. RESULTS:During follow-up, 784 (1.6%) patients with CeD were diagnosed with IBD compared with 1,015 (0.4%) matched comparators. In patients with CeD, the HR for IBD was 3.91 (95% confidence interval [CI] 3.56-4.31), with largely similar HRs for Crohn's disease (4.36; 3.72-5.11) and ulcerative colitis (3.40; 3.00-3.85). During follow-up, 644 (0.8%) patients with IBD and 597 (0.1%) comparators were diagnosed with CeD. The HR for CeD in patients with IBD was 5.49 (95% CI 4.90-6.16), with the highest risk estimates seen in ulcerative colitis (HR 5 6.99; 6.07-8.05), and the HR for Crohn's disease was 3.31 (2.69-4.06). In patients with CeD and IBD, the diagnostic interval was usually <1 year; however, HRs of 3-4 were seen even after 10 years of follow-up. During 20 years of follow-up, 2.5% of patients with CeD developed incident IBD, and 1.3% of patients with IBD developed CeD.

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Section: Discussionmentioning

confidence: 99%

Association of Celiac Disease and Inflammatory Bowel Disease: A Nationwide Register-Based Cohort Study

et al. 2022

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“…In the case of IBD, there is also an overlap between its symptoms and those of celiac disease that could result in misdiagnosis and delayed diagnosis of celiac disease. 16 Due to the fact that the IgA anti-tTG antibody assay is the best method for screening the cases suspected of celiac disease, 17 this study evaluated the IgA anti-tTG level in patients with IBD. The results cannot confirm an increase in celiac disease prevalence among patients with IBD since the IgA anti-tTG levels were lower than the standard index in the evaluated IBD patients.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of IgA Anti-tissue Transglutaminase Antibody in a Cohort of Iranians Patients with Inflammatory Bowel Disease

Memar,

Naghavi,

Vosoughinia

et al. 2023

Journal of Coloproctology

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Background and Aims Some studies have reported the coexistence of inflammatory bowel disease (IBD) and celiac disease (CD). However, the prevalence of anti-tissue transglutaminase antibodies (IgA and IgG) and their screening value in patients with IBD is not yet clear. This study aimed to assess the prevalence of IgA anti-tTG and its potential correlation with disease status in patients with IBD. Materials and Methods This cross-sectional study was conducted on 110 patients with confirmed IBD diagnosis at Ghaem Hospital, Mashhad, Iran. For each patient, all demographic and clinical data including age, extra intestinal manifestations, underlying diseases, types of diseases, and surgical history were collected. IgA anti-tissue transglutaminase titers were assessed by enzyme-linked immunosorbent assay. Results None of the patients with IBD were positive for IgA anti-tTG antibodies, with a mean titer of 3.31 ± 1.3 AU/mL. Also, the mean titers were not associated with age, gender and various disease clinical features including the disease history, underlying disease, diagnosis type, extraintestinal manifestations, and surgery history. Conclusion No significant prevalence pattern of IgA anti-tTG antibody was observed in patients with IBD. Accordingly, serological screening for CeD is not recommended in IBD patients, unless in a relevant clinical CeD suspicion.

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“…The Explorys rounds cell counts to the nearest 10 and treats all cell counts between zero and 10 as equivalent in order to protect the identities of patients. The Explorys database has been used in multiple publications in gastroenterology, cardiology, oncology, neurology, and surgery[ 13 , 14 ].…”

Section: Methodsmentioning

confidence: 99%

Takotsubo cardiomyopathy in orthotopic liver transplant recipients: A cohort study using multi-center pooled electronic health record data

Zmaili¹,

Alzubi²,

Alkhayyat³

et al. 2022

WJH

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BACKGROUND Takotsubo cardiomyopathy (TCM), or stress-induced cardiomyopathy, is associated with adverse prognosis. Limited data suggest that TCM occurring in orthotopic liver transplant (OLT) recipients is associated with elevated peri-operative risk. AIM To characterize the predictors of TCM in OLT recipients, using a large, multi-center pooled electronic health database. METHODS A multi-institutional database (Explorys Inc, Cleveland, OH, USA), an aggregate of de-identified electronic health record data from 26 United States healthcare systems was surveyed. A cohort of patients with a Systematized Nomenclature of Medicine-Clinical Terms of “liver transplant” between 09/2015 and 09/2020 was identified. Subsequently, individuals who developed a new diagnosis of TCM following OLT were identified. Furthermore, the risk associations with TCM among this patient population were characterized using linear regression. RESULTS Between 09/2015 and 09/2020, of 37718540 patients in the database, 38740 (0.10%) had a history of OLT (60.6% had an age between 18-65 years, 58.1% female). A new diagnosis of TCM was identified in 0.3% of OLT recipients (45.5% had an age between 18-65 years, 72.7% female), compared to 0.04% in non-OLT patients [odds ratio (OR): 7.98, 95% confidence intervals: 6.62-9.63, ( P < 0.0001)]. OLT recipients who developed TCM, compared to those who did not, were more likely to be greater than 65 years of age, Caucasian, and female ( P < 0.05). There was also a significant association with cardiac arrhythmias, especially ventricular arrhythmias ( P < 0.0001). CONCLUSION TCM was significantly more likely to occur in LT recipients vs non-recipients. Older age, Caucasian ethnicity, female gender, and presence of arrhythmias were significantly associated with TCM in LT recipients.

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Patients With Inflammatory Bowel Disease on Treatment Have Lower Rates of Celiac Disease

Cited by 6 publications

References 52 publications

Association of Celiac Disease and Inflammatory Bowel Disease: A Nationwide Register-Based Cohort Study

Association of Celiac Disease and Inflammatory Bowel Disease: A Nationwide Register-Based Cohort Study

Prevalence of IgA Anti-tissue Transglutaminase Antibody in a Cohort of Iranians Patients with Inflammatory Bowel Disease

Takotsubo cardiomyopathy in orthotopic liver transplant recipients: A cohort study using multi-center pooled electronic health record data

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