Patients withHelicobacter pyloripositive and negative duodenal ulcers have distinct clinical characteristics

Abstract

The proportion of patients with H pylori negative duodenal ulcers is on the rise because of a continued drop in incidence of H pylori positive duodenal ulcers in recent years. Such patients have distinct clinical characteristics and it is important to ascertain the H pylori status before starting eradication therapy.

Has Peptic Ulcer Disease Changed During the Past Ten Years in Korea? A Prospective Multi-center Study

“…Unfortunately, we could not compare our present results with our previous results ten years ago because we did not investigate the prevalence of IPUD ten years ago. IPUD was more frequently associated with complications in some reports [27][28][29]. However, patients with IPUD in the present study had no significant differences in clinical characteristics or complications when compared with patients that had either H. pylori or NSAID-associated PUD, with the exception that patients with H. pylori or NSAID-associated DU consumed more alcohol than those with IPUD.…”

An approach to duodenal biopsies

“…44 H pylori is associated with duodenal ulcer: 90% of the patients with duodenal ulcer are infected by H pylori. 45 Only a small percentage of cases of duodenitis are associated with the use of NSAIDs. Clearly, however, patients with duodenal ulcers of unknown aetiology may be more common than previously believed.…”

High prevalence of duodenal ulcer in a tertiary care hospital in the city of São Paulo, SP, Brazil

“…Within the duodenal ulcer group, 15 patients with serious co-morbidities had H. pylori-negative A ulcer. The clinical characteristics described of patients with H. pylori-negative duodenal ulcers were more likely to be older, have concomitant medical problem, pre-existing malignancy, recent surgery, underlying sepsis, or taken non-steroidal anti-inflammatory drugs (2) . This study has some limitations as the information concerning proton pump inhibitors, aspirin or NSAIDs intake, cigarette smoking, and alcohol consumption was not available.…”