Patients with high c‐<scp>MYC</scp>‐expressing squamous cell carcinomas of the tongue show better survival than those with low‐ and medium‐expressing tumours

Strindlund, Klas; Troiano, Giuseppe; Sgaramella, Nicola; Coates, Philip J.; Gu, Xiaolian; Boldrup, Linda; Califano, Luigi; Fåhræus, Robin; Muzio, Lorenzo Lo; Ardito, Fatima; Colella, Giuseppe; Tartaro, Gianpaolo; Franco, Renato; Norberg‐Spaak, Lena; Saadat, Mohammad; Nylander, Karin

doi:10.1111/jop.12579

Cited by 8 publications

(5 citation statements)

References 21 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cyclin D1 is a cell cycle-related factor associated with G1/S stage transition. C-Myc encodes phosphorylated proteins, which facilitate cell proliferation and differentiation (28). Cyclin D1 and c-Myc are downstream target genes of the Wnt/β-catenin signaling pathway (29).…”

Section: Discussionmentioning

confidence: 99%

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression

2018

View full text Add to dashboard Cite

Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of genistein on Wnt inhibitory factor 1 (WIF1) and invasion, and migration of colon cancer cells. The viability of HT29 colon cancer cells was suppressed by genistein in a dose dependent manner. Following 72 h of treatment with 10, 20 and 60 µmol/l genistein, increased demethylation of WIF1 was induced in a dose‑dependent manner. Additionally, the invasive/migratory abilities of cells treated with genistein decreased in a dose‑dependent manner. Reverse transcription‑quantitative polymerase chain reaction and western blot analyses were performed to identify the mRNA and protein expression levels of invasion/migration‑associated factors. Following treatment with genistein, matrix metalloproteinase (MMP) 2 and MMP9 expression levels decreased, whereas the expression of metalloproteinase inhibitor 1 and E‑cadherin increased significantly. In addition, the expression levels of proto‑oncogene Wnt‑1 (Wnt‑1)/β‑catenin pathway‑associated factors, β‑catenin, c‑Myc proto‑oncogene protein and cyclin D1 decreased in a dose‑dependent manner following treatment with genistein. The invasive/migratory abilities of cells transfected with WIF1‑small interfering (si) RNA, and those transfected with WIF1‑siRNA and treated with genistein, increased notably compared with the control group. The present study demonstrated that genistein was able to inhibit the cell invasion and migration of colon cancer cells by inducing demethylation, and recovering the activity of WIF1 by altering the expression of invasion‑associated factors, and components of the Wnt signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression

2018

View full text Add to dashboard Cite

show abstract

“…Nevertheless, compared with older patients, young patients have no history of tobacco or alcohol abuse. Furthermore, the time of exposure to these well‐known risk factors may not have been sufficient to promote malignant transformation, suggesting the involvement of other external or internal factors in the development of tongue cancer in this population 17‐21 . In the past years, an increasing incidence of TSCC has been registered in those countries where the primary prevention campaign to stop smoking and drinking has been active, thus suggesting the possible emerging role of new etiological or genetic factors driving carcinogenesis 5,10,11,22‐24 …”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

et al. 2021

View full text Add to dashboard Cite

While evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent. We performed a meta‐analysis of the literature to highlight key points that might help in understanding the association between age of oral tongue cancer patients at diagnosis and their prognosis. According to age at diagnosis, a systematic literature review of all published cohort studies assessing the recurrence risks and mortality associated with tongue cancer was conducted. We compared the risk estimates between patients aged >45 years and those aged <45 years at diagnosis. Random‐effects models were used to calculate summary relative risk estimates (SRRs) according to different clinical outcomes and sources of between‐study heterogeneity (I2) and bias. We included 31 independent cohort studies published between 1989 and 2019; these studies included a total of 28,288 patients. When risk estimations were not adjusted for confounders, no significant association was found between age at diagnosis and overall survival (OS). Conversely, after adjustment for confounders, older age at diagnosis was associated with a significantly increased risk of mortality. The difference between SRRs for adjusted and unadjusted estimates was significant (p < 0.01). Younger patients had a significantly higher risk of local recurrence. Younger patients with oral tongue cancer have better OS but a greater risk of recurrence than older patients. These findings should be validated in a large prospective cohort study which considers all confounders and prognostic factors.

show abstract

“…Several studies displayed significant association between the overexpression of c-Myc and poor prognosis in numerous tumors, while other studies revealed an opposite correlation. On the contrary, some reports did not support either of these conclusions (Zaharieva et al, 2005;Tsiatis et al, 2009;Massari et al, 2015;Zeng et al, 2015;Strindlund et al, 2017;He et al, 2018).…”

Section: Discussionmentioning

confidence: 95%

Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study

Elwy

Elsaba

Elzaher

et al. 2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Objective: This study aimed to investigate the immunohistochemical expression of c-Myc in muscle invasive urothelial carcinoma (MIUC) of the urinary bladder and to evaluate the correlation of c-Myc expression with different clinicopathological parameters and outcome, including a relatively new histopathological tumor characteristic that is the growth pattern of tumor invasion. Methods: A total of 66 formalin-fixed and paraffin-embedded sections of MIUC obtained from radical cystectomy specimens were enrolled. The sections were stained with c-Myc antibody using immunohistochemistry technique. Results: Tumor cells showed variability in nuclear c-Myc expression according to the growth pattern of invasion. The median H-score of nuclear expression of infiltrative pattern was significantly higher than that of non-infiltrative pattern (p<0.001). Nuclear expression of c-Myc in tumor tissue had a significant association with poor prognostic factors (sarcomatoid variant (p<0.001), perineural invasion (p=0.037), lymphovascular invasion (p<0.001), lymph node metastasis (p<0.001), distant metastasis (p=0.042) and advanced stage grouping (p=0.001). Kaplan Meier survival analysis demonstrated that c-Myc expression could not be significantly correlated with overall survival or disease free survival rates. Conclusion: Nuclear c-Myc seems to have a prominent role in epithelial to mesenchymal transition with consequential in tumor progression and metastasis, while it is not as much useful to predict the clinical behavior of patients with MIUC.

show abstract

Patients with high c‐MYC‐expressing squamous cell carcinomas of the tongue show better survival than those with low‐ and medium‐expressing tumours

Abstract: The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.

Cited by 8 publications

References 21 publications

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study

Contact Info

Product

Resources

About