Patients with Essential Hypertension Present Higher Levels of sE‐Selectin and sVCAM‐1 Than Normotensive Volunteers

Palomo, Iván; P, Marín; Alarcón, Marcelo; Gubelin, Gilda; Viñambre, Ximena; Mora, Eduardo Vazquez; Icaza, Gloria

doi:10.1081/ceh-120025335

Cited by 22 publications

(24 citation statements)

References 24 publications

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“…Similar to our findings literature reports elevated levels of sE-selectin (16)(17)(18), with exceptions by DeSouza et al (19) and Ferri et al (20); s-P-selectin (21-24), sICAM-1 (11,17,19,25,26) and sVCAM-1 (17)(18)(19) in hypertension. In the present study, as compared to controls increasing trend of sPECAM-1 in hypertension group was also observed.…”

Section: Discussionsupporting

confidence: 80%

“…Soluble levels of some of these molecules such as E-selectin, P-selectin, ICAM-1 and VCAM-1 have been explored in essential hypertension (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). The relationship between Creactive protein (CRP) and hypertension has also been studied (27,28) wherein prevalence of hypertension was demonstrated to be high in subjects with second, third and fourth quartile of high sensitivity (hs) CRP as compared to subjects in the first quartile.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating levels of cell adhesion molecules in hypertension

Shalia

Mashru

Vasvani

et al. 2009

Indian J Clin Biochem

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Circulating levels of cell adhesion molecules in hypertension

Shalia

Mashru

Vasvani

et al. 2009

Indian J Clin Biochem

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“…Hypertension is yet another prevalent cardiovascular risk factor in humans with uremia and is associated with increased sICAM-1 and sVCAM-1 (42,43). In contrast to humans, uremic apo-EϪ/Ϫ mice do not develop hypertension (8,9); therefore, elevated BP cannot explain the elevated CAM expression in the present study.…”

Section: Discussioncontrasting

confidence: 51%

Increased Expression of Adhesion Molecules in Uremic Atherosclerosis in Apolipoprotein-E–Deficient Mice

Bro¹,

Moeller²,

Andersen

et al. 2004

Journal of the American Society of Nephrology

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Abstract. Chronic renal failure markedly accelerates atherosclerosis in apolipoprotein-E-deficient mice, but the mechanism is unknown. The recruitment of inflammatory cells in the arterial wall by vascular adhesion molecules plays a key role in the formation of classical atherosclerosis. This study examines whether the expression of vascular adhesion molecules is increased in uremic atherosclerosis. Uremia was induced by 5/6 nephrectomy; control mice were sham-operated. After 2 wk of uremia, no lesion formation could be demonstrated in uremic or control mice. After 12 wk, aortas from uremic mice had a 9.8-fold increase of the aortic plaque area fraction compared with control mice (P Ͻ 0.0001). The aortic expression of intercellular adhesion molecule-1 (ICAM-1) mRNA in uremic mice was 215 Ϯ 31% (P Ͻ 0.05) and 243 Ϯ 55% (P Ͻ 0.05) of that in controls after 2 and 12 wk, respectively (n ϭ 9 ϫ 4). In contrast, aortic expression of vascular cell adhesion molecule-1 (VCAM-1) mRNA in uremic mice was unchanged after 2 wk but increased to 237 Ϯ 40% (P Ͻ 0.01) of that in control mice after 12 wk. On immunohistochemistry of aortas from uremic mice, ICAM-1 was predominantly present in endothelial cells both in nonlesioned and lesioned aortas, whereas VCAM-1 was predominantly present in the medial smooth muscle cell layer in lesioned aortas. The plasma concentration of soluble ICAM-1 (sICAM-1) (but not of sVCAM-1) was slightly elevated after 2 wk of uremia. In contrast, both sICAM-1 and sVCAM-1 plasma concentrations were markedly higher in uremic than control mice after 12 wk. These results suggest that uremic atherosclerosis is preceded by an upregulation of ICAM-1 expression in arterial endothelium and that formation of early uremic lesions is accompanied by upregulation of VCAM-1 expression in the medial smooth muscle cell layer.

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“…La capacidad para detectar y vigilar múltiples factores que causan daño endotelial tiene gran importancia para estratificar el riesgo cardiovascular (52). Las ROS y moléculas inflamatorias activan vías de transcripción del factor nuclear-kB (NF-kB) o proteína activadora 1 (AP-1), gatillando la expresión de moléculas de adhesión celular como la molécula de citoadhesión vascular-1 (VCAM-1) y la molécula de adhesión intercelular-1 (ICAM-1) (53)(54)(55).…”

Section: Disfunción Endotelialunclassified

El Consumo De Frutas Y Hortalizas Ayuda a Prevenir El Daño Endotelial

Palomo

Moore‐Carrasco

et al. 2011

Rev. chil. nutr.

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INTRODUCCIÓNLa células endoteliales, entre otras funciones, regulan el tono y permeabilidad vascular, adhesión leucocitaria y la hemostasia (1). Dentro de los mecanismos que regulan las funciones del endotelio, la producción de óxido nítrico (NO) es de central importancia. ABSTRACT The endothelium helps to maintain the normal structure and homeostasis of the vasculature. However, chronic exposure to cardiovascular (CV) risk factors causes endothelial dysfunction, a phenomenon that is characterized by inflammation, reduced bioavailability of nitric oxide (NO) and a prothrombotic state. Epidemiological studies have shown that regular consumption of fruits and vegetables reduces CV risk, which has caused interest in knowing the bioactive compounds and the mechanisms involved. Among the components that protect the endothelium are antioxidants (vitamin C, vitamin E and polyphenols) and polyunsaturated fatty acids. Vitamin C and E promote vasodilatation protecting NO by blocking the reactive oxygen species (ROS). Polyphenols improve endothelial function primarily by increasing levels of NO, and inhibition of angiogenesis and platelet activation. Diets rich in polyunsaturated fatty acids have shown beneficial effects by reducing the gene expression of cyclooxygenase-2 and the expression of cell adhesion molecules. This review mainly highlights the current understanding of endothelial dysfunction and the protective effect of endothelial cells by bioactive components of fruits and vegetables.

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Patients with Essential Hypertension Present Higher Levels of sE‐Selectin and sVCAM‐1 Than Normotensive Volunteers

Cited by 22 publications

References 24 publications

Circulating levels of cell adhesion molecules in hypertension

Circulating levels of cell adhesion molecules in hypertension

Increased Expression of Adhesion Molecules in Uremic Atherosclerosis in Apolipoprotein-E–Deficient Mice

El Consumo De Frutas Y Hortalizas Ayuda a Prevenir El Daño Endotelial

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