Patients with early-onset rectal cancer aged 40 year or less have similar oncologic outcomes to older patients despite presenting in more advanced stage; A retrospective cohort study

Emile, Sameh Hany; Elfeki, Hossam; Shalaby, Mostafa; Elbalka, Saleh S.; Metwally, Islam H.; Abdelkhalek, Mohamed

doi:10.1016/j.ijsu.2020.09.029

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…Higher local recurrence might be also attributed to the younger age of patients in our study as the mean age was 47 years. Such young‐onset rectal cancer has been previously reported by our group and other investigators from Egypt 30,31 . While the explanation of this young onset of rectal cancer in our country is unclear and needs to be thoroughly studied, it may contribute to a worse outcome and higher recurrence after curative surgery for CRC 32,33 …”

Section: Discussionmentioning

confidence: 51%

“…Such young-onset rectal cancer has been previously reported by our group and other investigators from Egypt. 30,31 While the explanation of this young onset of rectal cancer in our country is unclear and needs to be thoroughly studied, it may contribute to a worse outcome and higher recurrence after curative surgery for CRC. 32,33 The higher local recurrence reported in our study may affect the accuracy of the PREDICT score when applied to other cohorts with lower rates of local recurrence.…”

Section: Diagnostic Accuracy Of the Predict Score In Prediction Of Lo...mentioning

confidence: 99%

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Multicenter validation of the PREDICT score for prediction of local recurrence after total mesorectal excision of rectal cancer

Emile

Madbouly

Elfeki

et al. 2022

Journal of Surgical Oncology

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Background Total mesorectal excision (TME) is the gold standard treatment for rectal cancer. Although TME has managed to decrease the rates of local recurrence after rectal cancer resection, local recurrence is still recorded at varying rates. The present study aimed to validate the PREDICT score in the prediction of local recurrence of rectal cancer after TME with curative intent. Methods This was a retrospective multicenter study on patients with nonmetastatic low or middle rectal cancer who underwent TME. The total PREDICT score was calculated for every patient and related to the onset of local recurrence. According to the final score, patients were allocated to one of three risk groups: low, moderate, and high, and the rates of local recurrence in each group were calculated and compared. Results The present study included 262 patients (50.4% males) with a mean age of 47.1 years. The overall local recurrence rate was 12.6%. 29.4% of patients were in the low‐risk group, 63.7% in the moderate‐risk group, and 6.9% in the high‐risk group. The local recurrence rate was 3.9% (95% confidence interval [CI]: 0.8–10.9) in the low‐risk group, 13.2% (95% CI: 8.4–19.3) in the moderate risk group, and 44.4% (95% CI: 21.5–69.2) in the high‐risk group (p < 0.0001). The sensitivity of the PREDICT score was 72.7%, the specificity was 88.1%, and the accuracy was 86.3%. Conclusions The PREDICT score had good diagnostic accuracy in the prediction of local recurrence after TME and a good discriminatory ability in the differentiation between patients at different risks to develop local recurrence.

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Section: Discussionmentioning

confidence: 51%

Section: Diagnostic Accuracy Of the Predict Score In Prediction Of Lo...mentioning

confidence: 99%

Multicenter validation of the PREDICT score for prediction of local recurrence after total mesorectal excision of rectal cancer

Emile

Madbouly

Elfeki

et al. 2022

Journal of Surgical Oncology

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“…Many experts have suggested that elderly people's cancer may be biologically harmless [22,23]. As such, youthful cancer sufferers are thought to possess less favorable outcomes compared to those who are older [24][25][26][27]. Applying propensity score matching, Tang et al [2] evaluated teens and young adults following a radical removal of pancreatic ductal adenocarcinoma and found that cancer might be more serious in those years.…”

Section: Discussionmentioning

confidence: 99%

Safety and hazards of middle-life robotic pancreaticoduodenectomy

Saad,

Baz,

Riad

et al. 2023

Preprint

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Pancreaticoduodenectomy procedures were performed early in young individuals, with a few days about the risk and survival after robotic pancreaticoduodenectomy. Our goal was to report the results of robotic pancreaticoduodenectomy in patients older than 50 years. Methods Our patients were divided into two groups: younger patients (less than 50 years) and older patients (> 50 years). A total of 1110 patients were included in this study:1004 (90.5%) in the elderly group and 106 (9.5%) in the young group. Results In younger demographics, the prevalence of periampullary cancer is 32.1% as opposed to 76.5%. 2. Tumors biological (15.1% versus 3.6%). 3. Pseudocapillary and solid malignancies (9.4% and 1.0%, respectively). 4. The tissues soft of the pancreas (77.4% vs. 62.5%). There was a higher prevalence of non-dilated (≤ 3 mm) ducts within the pancreas (77.4% vs. 46.3%) in the younger group. 6. Young people group's hospitalization was less (median, 16 vs. 20 days). 7- The younger group fared better after treatment for total periampullary cancers of the with a 5-year prognosis of 76.4% compared to 46.7% in the older category. 8. The results of the other surgeries didn't vary significantly. Conclusions Robotic pancreaticoduodenectomy is associated with favorable survival outcomes for periampullary cancer in younger people (<50 years) and equivalent surgical outcomes compared to older individuals (≥50 years). These outcomes show that robotic pancreaticoduodenectomy is safe and effective in a subset of pediatric patients. Following pancreaticoduodenectomy, the number of juvenile robotic tumor adenocarcinomas

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“…Some authors believe that cancer in elderly patients may be biologically less aggressive [22,23]. Therefore, the younger patients with cancer are thought to have a worse prognosis than the older patients [24][25][26][27]. Tang et al [2] conducted a comparative study of adolescents and young adults after radical resection of pancreatic ductal adenocarcinoma by propensity score matching and concluded that pancreatic ductal adenocarcinoma may be more aggressive in adolescents and young adults.…”

Section: Discussionmentioning

confidence: 99%

Robotic pancreaticoduodenectomy in the young

Shyr,

Shih,

Wang

et al. 2023

Preprint

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Pancreaticoduodenectomy is rarely performed in young patients, and the impact of age on surgical and survival outcomes after robotic pancreaticoduodenectomy has not been extensively studied. This study aimed to evaluate the surgical and survival outcomes of patients aged < 50 years who underwent robotic pancreaticoduodenectomy. A comparative study was conducted on patients who underwent robotic pancreaticoduodenectomy divided into two groups: young (age, < 50 years) and old (age, ≥ 50 years). A total of 555 patients were included in this study, with 53 (9.5%) in the young group and 502 (90.5%) in the old group. Periampullary adenocarcinomas were less common in the young group (32.1% vs. 76.5%), whereas solid and pseudopapillary tumors (9.4% vs. 1.0%) and neuroendocrine tumors (15.1% vs. 3.6%) were more common. Soft pancreatic parenchyma (77.4% vs. 62.5%) and non-dilated (≤ 3 mm) pancreatic ducts (77.4% vs. 46.3%) were more prevalent in the young group. The young group had a shorter length of stay (median, 16 vs. 20 days). There were no significant differences in the other surgical outcomes and risks. Survival outcomes for overall periampullary adenocarcinoma favored the young group, with a 5-year survival rate of 76.4% vs. 46.7% in the old group. Robotic pancreaticoduodenectomy in the young patients (< 50 years) is associated with comparable surgical outcomes and favorable survival outcomes for periampullary adenocarcinoma compared with the older patients (≥ 50 years). These findings highlight the feasibility and safety of robotic pancreaticoduodenectomy in the young population.

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Patients with early-onset rectal cancer aged 40 year or less have similar oncologic outcomes to older patients despite presenting in more advanced stage; A retrospective cohort study

Cited by 11 publications

References 32 publications

Multicenter validation of the PREDICT score for prediction of local recurrence after total mesorectal excision of rectal cancer

Multicenter validation of the PREDICT score for prediction of local recurrence after total mesorectal excision of rectal cancer

Safety and hazards of middle-life robotic pancreaticoduodenectomy

Robotic pancreaticoduodenectomy in the young

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