Patients with diffuse idiopathic skeletal hyperostosis do not have increased peripheral bone mineral density and geometry

Eser, Prisca; Bonél, Harald; Seitz, Michael; Villiger, Peter M.; Aeberli, Daniel

doi:10.1093/rheumatology/keq014

Cited by 26 publications

(13 citation statements)

References 15 publications

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“…9 Entheseal ossification and calcifications may falsely increase bone mineral density readings by dual-energy X-ray absorptiometry, but peripheral quantitative CT has shown that bone density and geometry are not altered in patients with DISH. 10 Nevertheless, CT examinations are generally rarely performed even in suspicious cases due to the associated radiation exposure. Recently, a few studies with MRI or ultrasonography (US) suggested that a local entheseal inflammatory process might precede the ossification process.…”

mentioning

confidence: 99%

Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next

Mader¹,

et al. 2017

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confidence: 99%

Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next

Mader¹,

et al. 2017

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“…Our results and the limited literature available [10,17] suggest that IMAT analysis protocols need further development and validation, with muscle density used in lieu of IMAT to quantify intermuscular adipose tissue content. Several recent papers report using pQCT to quantify SAT area in the lower leg [15,16,19,23,45,53,54]; however, only three studies reported precision estimates for this outcome [15,23,25]. Our lower leg and forearm precision ranged from 2.4 to 6.4% for SAT area.…”

Section: Discussionmentioning

confidence: 88%

Measurement of muscle and fat in postmenopausal women: precision of previously reported pQCT imaging methods

Frank-Wilson

Johnston

Olszynski

et al. 2015

Bone

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“…DISH is more prevalent in men, and the incidence increases with age [ 15 ]. The protective effect of estrogens on the development of DISH seems to be of metabolic nature, since differences of volumetric bone density and osteoblast activity have not been seen in quantitative bone scans or functional Dickkopf-1 serum levels [ 16 – 18 ]. This hormonal influence is in line with associations of DISH with obesity, diabetes, hyperlipidemia, gout, hypertension and coronary artery disease as described previously [ 2 , 9 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse idiopathic skeletal hyperostosis (DISH) of the elbow: a controlled radiological study

Beyeler

Thomann

Gerber

et al. 2015

BMC Musculoskelet Disord

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BackgroundExtraspinal manifestations of diffuse idiopathic skeletal hyperostosis (DISH) have been described previously. We aimed to assess the prevalence of elbow hyperostotic spurs, to search for sites discriminating for elbow DISH and to analyze the effect of physical activities, handedness and sex.MethodsOut of 284 patients hospitalized for extraskeletal disorders, 85 patients (33 with and 52 without thoracospinal DISH) agreed to bilateral elbow X-rays in two projections. Clinical information was collected by a standardized questionnaire and X-rays were graded blindly.ResultsA total of 400 hyperostotic spurs (210 unilateral, 95 bilateral) were present at 11 predefined sites. The most frequent sites affected were the olecranon (20.8 %), lateral epicondyle (17.8 %) and medial epicondyle (15.5 %). In carriers of thoracospinal DISH significantly more hyperostotic spurs were present at the lateral and medial epicondyle compared to non-DISH carriers (OR 4.01 [95 % CI 1.35–12.34] and 2.88 [1.03–8.24], respectively). The olecranon, lateral and medial epicondyle contributed significantly to the classification of elbow DISH (OR 22.2 [4.1–144.7], 9.6 [1.9–61.2] and 10.1 [2.2–52.1], respectively). The prevalence of elbow hyperostotic spurs was higher in 45 patients with a history of heavy physical activities (24.4 % versus 18.0 %, OR 1.48 [1.17–1.86]), at the right elbow (24.2 % versus 18.6 %, OR 1.39 [1.11–1.75]) and in 62 males (22.8 % versus 17.6 %, OR 1.38 [1.06–1.81]).ConclusionsHyperostotic spurs at the olecranon, lateral and medial epicondyle had the highest prevalence and disclosed the most pronounced discrimination for elbow DISH. Mechanical factors such as physical activities and handedness, and sex influenced the formation of these spurs.Electronic supplementary materialThe online version of this article (doi:10.1186/s12891-015-0575-5) contains supplementary material, which is available to authorized users.

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Patients with diffuse idiopathic skeletal hyperostosis do not have increased peripheral bone mineral density and geometry

Abstract: In contrast to suggestions based on DXA, pQCT revealed that DISH patients do not have increased vBMD and bone geometry in the appendicular skeleton. Ossification at tendon or ligament insertion sites may lead to overestimation of aBMD if assessed by DXA.

Cited by 26 publications

References 15 publications

Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next

Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next

Measurement of muscle and fat in postmenopausal women: precision of previously reported pQCT imaging methods

Diffuse idiopathic skeletal hyperostosis (DISH) of the elbow: a controlled radiological study

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