Patients with chronic periodontitis present increased risk for osteoporosis: A population‐based cohort study in Taiwan

Mau, Lian Ping; Kuan, Yu-Chen; Tsai, Yang‐Te; Lin, Jiang; Huynh‐Ba, Guy; Weng, Pei-Wei; Shieh, Yi‐Shing; Cheng, Wan Chien; Huang, Ren‐Yeong

doi:10.1111/jre.12464

Cited by 27 publications

(37 citation statements)

References 43 publications

(75 reference statements)

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“…Хронический генерализованный пародонтит (ХГП) все чаще встречается у пациентов молодого возраста, что определяет его как социально значимую медицинскую проблему [1,2]. Хронический генерализованный пародонтит всегда протекает с убылью костной ткани, усугубляясь системным остеопорозом различной этиологии (гормональные нарушения, пре-, постменопаузный период, болезни обмена веществ) [3][4][5]. Современные взгляды на развитие воспалительно-деструктивных форм пародонтита дополняются исследованиями об изменениях в клеточном и гуморальном звеньях иммунитета тканей пародонта [6,7].…”

Section: оригинальные исследованияunclassified

“…При остеопорозе отмечено значительное увеличение количества СD3+ клеток -до 15-20 на 100 эпителиоцитов (рис. [2][3][4].…”

Section: оригинальные исследованияunclassified

“…В слизистой оболочке контрольной группы животных с пародонтитом обнаружено от 5 до 9 СD4+ клеток, локализованных в основном в базальном и толще шиповатого слоя (рис. [2][3][4][5]. В пределах эпителия слизистой оболочки при остеопорозе количество СD4+ клеток увеличивалось до 12-16 (на 100 эпителиоцитов).…”

Section: оригинальные исследованияunclassified

“…Отмечена тенденция накопления СD4+ клеток на верхушках сосочков в базальных отделах эпителия (рис. [2][3][4][5][6]. Около трети из всех обнаруженных СD4+ клеток имели отростки различной длины.…”

Section: оригинальные исследованияunclassified

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Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Sirak¹,

Rubnikovich²,

Shchetinin³

et al. 2019

Medical news of the North Caucasus

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1 stavropol state medical university, russian Federation 2 medical academy of Postgraduate education, minsk, republic Belarus 3 Kuban state Мedical university, Krasnodar, russian Federation изложены результаты исследований по разработке модели остеопороза у экспериментальных животных с последующим анализом картины иммунного ответа тканей пародонта через 90 и 180 суток после начала формирования модели. результаты исследования показали, что уменьшение числа ЕК-клеток в сочетании с увеличением т-клеточной популяции (CD3+, CD4+, CD8+) отражает усиленный иммунный ответ в условиях повышенной антигенной нагрузки при остеопорозе. При этом количественные показатели В-клеток, как показали проведенные исследования, остаются без изменений. Ключевые слова: остеопороз, пародонтит, иммунный ответ, экспериментThe materials of the article contain data on the development of a model of osteoporosis in experimental animals, followed by a detailed description of the immune response of periodontal tissues 90 and 180 days after the beginning of the model formation. The results of the study showed that the decrease in the number of EC cells in combination with an increase in the T-cell population (CD3+, CD4+, CD8+) reflects an enhanced immune response in conditions of increased antigenic load in osteoporosis. At the same time, the quantitative indicators of B cells, as shown by the studies, remain unchanged.

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Section: оригинальные исследованияunclassified

See 2 more Smart Citations

Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Sirak¹,

Rubnikovich²,

Shchetinin³

et al. 2019

Medical news of the North Caucasus

View full text Add to dashboard Cite

show abstract

“…22,23 Localized chronic periodontitis was defined as at least one tooth but fewer than six teeth having at least one site with PD ≥5 mm and radiographic bone loss. 22,23 The patients with periodontitis were treated by non-surgical and/or surgical treatments before implant placement and had at least two maintenance appointments each year. Some patients might have sites with residual PD ≥5 mm after treatments depending on the outcomes of treatments.…”

Section: Patient Recruitmentmentioning

confidence: 99%

Survival rates of hybrid rough surface implants and their alveolar bone level alterations

Lee

Tran

Jeng

et al. 2018

Journal of Periodontology

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Association of chronic periodontitis with prostatic hyperplasia and prostatitis: A population‐based cohort study in Taiwan

Cheng

Chung

et al. 2020

Journal of Periodontology

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Background Association between periodontitis and prostate diseases of benign prostatic hyperplasia (BPH) and prostatitis is uncertain. Methods From the National Health Insurance Research Database of Taiwan, 5,510 patients with newly diagnosed chronic periodontitis and participated in therapies were selected from 2000 to 2015 as cohort 1. Matched with age and index year, 5,510 patients with periodontitis diagnosis without therapy were selected as cohort 2, and 5,510 participants without diagnosis were used as control. Cox proportional hazard and survival analysis were performed to compare the risks and the survival probabilities among cohorts. Results In two periodontitis cohorts, 636 and 638 participants compared with 550 in control (1,174 and 1,187 versus 989 per 100,000 person‐years) had prostate disorder. Difference was identified for prostatitis (n = 68, 70 versus 34; rate = 125, 130 versus 61 /100,000 person‐years; P <0.001) but not for BPH (n = 577, 575, versus 529; rate = 1,065, 1,070 versus 951 /100,000 person‐years, respectively). Different survival probabilities for prostate disorder and prostatitis, but not for BPH, were observed among cohorts. Periodontitis patients were more likely to develop prostate disorder after adjustment (adjusted hazard ratio [aHR] of 2.590 to 2.641 by competing model). With stratification, risks between two periodontitis cohorts exhibited no difference. When BPH cases were excluded, the aHRs for prostatitis were 4.611 to 4.798. Conclusions Despite treatment, the patients with periodontitis had higher risk of developing prostatitis than patients without periodontitis.

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Patients with chronic periodontitis present increased risk for osteoporosis: A population‐based cohort study in Taiwan

Abstract: This study found that patients with periodontitis had a higher risk of being diagnosed with osteoporosis.

Cited by 27 publications

References 43 publications

Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Survival rates of hybrid rough surface implants and their alveolar bone level alterations

Association of chronic periodontitis with prostatic hyperplasia and prostatitis: A population‐based cohort study in Taiwan

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