Patients with cervical cancer without visceral obesity had better treatment outcomes

Abstract

Background: Obesity is associated with malignant tumor development and may affect cancer outcomes.This study is to assess the relationship between the visceral fat-subcutaneous fat ratio (V/S ratio) and overall survival (OS) in cervical cancer patients.Methods: We studied the data of patients with stage I-III cervical cancer who received definitive concurrent chemoradiotherapy (CCRT) from 2010 to 2013 at a single institution. Their visceral and subcutaneous fat areas were delineated from simulated CT images obtained at the L4 level before radiotherapy. A V/S ratio threshold of 0.55 was set for defining visceral obesity; a V/S threshold of ≥0.55 was considered to indicate visceral obesity.Results: A total of 25 women were included for analysis. The 5-year survival rate was 60% in all patients.The 5-year survival rate was 82.5% in patients with a V/S ratio of <55% and 30.3% in those with a V/S ratio of ≥55%. The association between OS and the V/S ratio was statistically significant (P=0.021).Conclusions: Patients without visceral obesity had a higher OS than did those with visceral obesity.

High visceral fat-to-muscle ratio is an independent factor that predicts worse overall survival in patients with primary epithelial ovarian, fallopian tube, and peritoneal cancer

“…Instead, we demonstrated that the The clinical significance of visceral fat area depends on the type of malignancy. While higher visceral fat was significantly associated with better OS in gastric cancer [14], a higher visceral to subcutaneous fat ratio was significantly associated with worse OS in uterine cervical, pancreatic, and metastatic colorectal cancer [15][16][17].…”