Patients with celiac disease may have normal weight or may even be overweight

Singh, Isha; Agnihotri, Abhishek; Sharma, Anubhuti; Verma, Anil K.; Das, Prasenjit; Thakur, Bhaskar; Sreenivas, V.; Gupta, Siddhartha Datta; Ahuja, Vineet; Makharia, Govind

doi:10.1007/s12664-016-0620-9

Cited by 35 publications

(30 citation statements)

References 20 publications

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“…In a retrospective study of 390 Israeli children recently diagnosed, with an average age of 7.1 years, an 11.8% overweight and 5.6% obesity prevalence was reported 20 . In line with these results, the CD pediatric population in Western countries shows a malnutrition prevalence between 8% and 40% 21 . The coexistence of CD and obesity has been explained by the compensation theory, according to this hypothesis, those nutrients that cannot be absorbed due to the villi atrophy in the proximal small intestine is compensated by the increase in the absorption capacity of the distal small intestine.…”

Section: Discussionsupporting

confidence: 79%

Concentraciones de Vitamina D en niños y adolescentes con enfermedad celíaca

Granfeldt

Zapata

Muñoz

et al. 2018

Rev. chil. pediatr.

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Introduction:In children with celiac disease, gluten intake causes an autoimmune, inflammatory and progressive lesion of the small intestine villi, compromising the absorption of nutrients and possible damage to others organs. Objective: To determine plasma 25-hydroxyvitamin D [25(OH)D] concentrations in Chilean child and adolescents with celiac disease. Patients and Method: A descriptive cross-sectional study was carried out in which 16 pediatric patients of both genders diagnosed with celiac disease participated. General background, nutritional status and biochemical parameters were determined. Plasma 25(OH)D concentrations were classified as sufficient between 30-100 ng/ ml, insufficient between 20-30 ng/ml and deficient as <20 ng/ml. Results: The age of the patients was between 5 and 18 years (age: 11 ± 4 years). Four out of 16 participants had normal 25(OH)D concentrations, eight had insufficient concentrations and one had deficient concentrations. According to BMI, 11 patients had normal nutritional status, four were overweight and one was obese. In relation to height, seven out of 16 cases presented short stature and normal-low height. Associating 25(OH)D concentrations to nutritional status, nine patients with normal nutritional status, two with overweight and one with obesity presented deficient and insufficient parameters. No significant associations were found between 25(OH)D concentrations and all studied variables. Conclusion: A high frequency of insufficiency and deficiency of 25(OH)D was found in the group of Chilean children and adolescents with celiac disease.

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Section: Discussionsupporting

confidence: 79%

Concentraciones de Vitamina D en niños y adolescentes con enfermedad celíaca

Granfeldt

Zapata

Muñoz

et al. 2018

Rev. chil. pediatr.

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“…Celiac disease (CeD) is usually considered to lead to undernutrition and low weight both in children and adults; in recent times, however, many patients with CeD are found to be not only overweight but some even being obese. 1 In a retrospective study, we observed that 54.8% of treatment naïve patients with CeD had their BMI within normal limits, 8.1% of them, however, were either overweight or obese. 1 Numerous other and end up developing metabolic syndrome, the pathogenesis of this condition is not very clear.…”

Section: Introductionmentioning

confidence: 93%

“…1 In a retrospective study, we observed that 54.8% of treatment naïve patients with CeD had their BMI within normal limits, 8.1% of them, however, were either overweight or obese. 1 Numerous other and end up developing metabolic syndrome, the pathogenesis of this condition is not very clear. Processed GFD is considered to be nutritionally imbalanced that lead to a higher intake of carbohydrates with a higher glycemic index.…”

Section: Introductionmentioning

confidence: 93%

Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver

et al. 2021

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studies have made similar observations and up to 44% of the patients were found to be overweight or obese at the time of diagnosis of CeD. 2,3 Furthermore, many studies have uniformly shown that underweight patients at the time of diagnosis tend to gain weight on gluten-free diet (GFD). 4-6 Contradictory to that while 22% to 82% of overweight and obese patients gain weight on a GFD; 4,7 some of the overweight and obese patients with CeD lose weight on GFD. 6,8 As described above, many studies have looked into the effect of a GFD on BMI but the association between CeD and metabolic syndrome has not been explored in much detail. In a recent prospective study, Tortora et al. 9 reported an increase in the prevalence of metabolic syndrome from 2% at the time of diagnosis to 30% after 12 months of GFD. Although there is emerging evidence that a sizeable proportion of patients with CeD gain weight

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“…The global prevalence of the disease has been shown to range from between one and two per cent, where the presentation of CD has significantly changed over the years; whereby, in the last twenty-five years, the most notable symptoms, such as malab sorption and diarrhoea have radically reduced during the onset of the disease in both children and adults, making this disease even more difficult to diagnose at the onset [14,17]. Likewise, the atypical presentation of the disease has been reported to have significantly increased [18].…”

Section: Introduction Backgroundmentioning

confidence: 99%

“…Previously, the micronutrient deficiency symptoms of CD, such as anemia, meant weight loss and frail body types, however, studies are now showing more research towards overweight and obese individuals with the same micronutrient deficiencies [18]. Therefore, the continued differences in presentation or manifestation of the disease in both children and adults indicate a critical aspect in the misdiagnosis and correlation of the disease with obesity; thus, some recent studies have tried to investigate clinical presentations of the two conditions.…”

Section: Introduction Backgroundmentioning

confidence: 99%

Failure to Thrive: A Review for a Relationship between Coeliac Disease and Obesity

2018

Medical &Amp; Clinical Research

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Objectives: The primary objective of this review was to provide a systematic review of the literature on the relationship between CD and obesity. Further, the reviewer had the purpose of conducting an investigation on this correlation, ranging from pediatrics to adults, in specific areas such as the mechanism of the two conditions and the nutritional interventions. The mechanism review involved finding any pathogenic and pathophysiological link between the two conditions and investigating the possible association in clinical evidence and manifestations and of the symptoms. As a result, the present research was designed to establish a paper that can effectively inform not only the public but health care providers, concerning the importance of proper and time-sensitive diagnosis. Methods: In order to achieve these objectives, the researcher conducted desk-based research, which involved a comprehensive review of numerous journal articles drawn from various publishers. The search strategy involved the use of both internal and external secondary sources of information obtained from Science Direct, PubMed, Journal of Paediatric Gastroenterology and Nutrition, The American Journal of Clinical Nutrition, and The European Journal of Clinical Nutrition, among others. Moreover, the search strategy also considered the mechanistic pathology, functional physiology, and human intervention. Results: The key pathophysiological findings indicated that CD and obesity have a connection in the context of the predisposing factors, which are genetic, environmental and immunological factors. Further, the two conditions also show connection in the aspects of human nutritional interventions, where the intervention for CD was established to involve a GFD, however, some patients have been recorded as becoming obese once they start the treatment process. Conclusion: Conclusively, it was important establishing a link between obesity and CD based on the clinical implications of the findings, as well as the general healthcare field; where, the present paper points out for the proper diagnosis of both conditions, whether the symptoms are atypical or not. Hence, it was important to provide a precise nutritional intervention for future patients, which may involve an introduction of a GFD before diagnosis, and strict follow-up and education for the patients on the importance of this intervention.

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Patients with celiac disease may have normal weight or may even be overweight

Abstract: In our practice, only one third of patients with CeD had low BMI. A diagnosis of CeD should not be excluded if patient has normal or high BMI.

Cited by 35 publications

References 20 publications

Concentraciones de Vitamina D en niños y adolescentes con enfermedad celíaca

Concentraciones de Vitamina D en niños y adolescentes con enfermedad celíaca

Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver

Failure to Thrive: A Review for a Relationship between Coeliac Disease and Obesity

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