Patients with Castleman disease report mild COVID-19 symptoms and mount a humoral response to SARS-CoV-2 vaccination

Shyamsundar, Saishravan; Pierson, Sheila K.; Connolly, Caoilfhionn M.; Teles, Mayan; Segev, Dorry L.; Werbel, William A.; van Rhee, Frits; Casper, Corey; Brandstadter, Joshua D.; Noy, Ariela; Fajgenbaum, David C.

doi:10.1016/j.bneo.2024.100002

Cited by 1 publication

(2 citation statements)

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“…The authors stated that hyperinflammation plays a pivotal role in severe COVID-19 and TAFRO syndrome. There is concern that COVID-19 may exacerbate cytokine storms in patients with iMCD and TAFRO syndrome; however, a recent report suggests that iMCD flare-ups were actually infrequent [ 64 ]. Since the COVID-19 pandemic, there have only been a few case reports about the onset of TAFRO syndrome or iMCD.…”

Section: Tafro Syndrome and Covid-19mentioning

confidence: 99%

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TAFRO Syndrome and COVID-19

Tane,

Kosako,

Sonoki

et al. 2024

Biomedicines

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TAFRO syndrome is a systemic inflammatory disease characterized by thrombocytopenia and anasarca. It results from hyperinflammation and produces severe cytokine storms. Severe acute respiratory syndrome coronavirus 2, which led to the coronavirus disease 2019 (COVID-19) pandemic, also causes cytokine storms. COVID-19 was reported to be associated with various immune-related manifestations, including multisystem inflammatory syndrome, hemophagocytic syndrome, vasculitis, and immune thrombocytopenia. Although the pathogenesis and complications of COVID-19 have not been fully elucidated, the pathogeneses of excessive immunoreaction after COVID-19 and TAFRO syndrome both involve cytokine storms. Since the COVID-19 pandemic, there have been a few case reports about the onset of TAFRO syndrome after COVID-19 or COVID-19 vaccination. Castleman disease also presents with excessive cytokine production. We reviewed the literature about the association between TAFRO syndrome or Castleman disease and COVID-19 or vaccination against it. While the similarities and differences between the pathogeneses of TAFRO syndrome and COVID-19 have not been investigated previously, the cytokines and genetic factors associated with TAFRO syndrome and COVID-19 were reviewed by examining case reports. Investigation of TAFRO-like manifestations after COVID-19 or vaccination against COVID-19 may contribute to understanding the pathogenesis of TAFRO syndrome.

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Section: Tafro Syndrome and Covid-19mentioning

confidence: 99%

“…The elevation of IL-6 levels by vaccination may serve as a trigger for the onset of iMCD. On the other hand, a cohort study showed that only 1 of 112 patients with iMCD developed disease flare [ 64 ]. Further studies are needed to elucidate the association of iMCD and vaccination against COVID-19.…”

Section: Tafro Syndrome and Covid-19mentioning

confidence: 99%