Patients with atopy exhibit reduced cortisol awakening response but not cortisol concentrations during the rest of the day

Rajčáni, Jakub; Soláriková, Petra; Buzgoova, K.; Brezina, Igor; Ježová, Daniela

doi:10.1007/s12026-019-09076-w

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…No effect of allergy on the neuroendocrine response was revealed by the present analysis, which is supposedly in contrast to previously published data on the reduced sAA and/or cortisol responses to psychosocial stress tests (Buske- Kirschbaum et al 2010;Hlavacova et al 2017) or awakening (Rajcani et al 2019) in allergy. However, the present study was not aimed to investigate the effect of allergy.…”

Section: Discussioncontrasting

confidence: 99%

Neuroendocrine responses to a psychosocial stress test for larger groups of participants: comparison of two test exposures

Rajčáni

Soláriková

Brezina

et al. 2020

Endocrine Regulations

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Objective. Individual stress tests characterized by social evaluative threat and uncontrollability are known to elicit strong neuroendocrine responses. We tested whether a psychosocial stressor submitted to a larger group of participants (up to 60) may elicit comparable stress responses. Methods. A total of 59 adult subjects (33 women, 26 men) participated in the study, whereas 24 of them suffered from allergy and 35 were healthy. The stress test consisted of a distraction stress task followed by a speech task, in which the participants were randomly subjected to questions related to a topic that they had to prepare as well as arithmetic questions in front of their peers and a committee that responded in standardized and non-supporting manner. State and trait anxiety inventory (STAI) for anxiety state was administrated before and after the test and salivary samples taking. The test was repeated after five months. Results. The results showed that the shared psychosocial stress application in a larger group of subjects was prosperous. The larger group test (LGST) resulted in an enhanced subjectively experienced stress and an intensive sympathetic nervous system activation, reflected by elevated salivary alpha-amylase activity and the heart rate. The cortisol increment after exposure to the stress test was not significant. Repeated exposure to the test failed to reproduce the original stress responses with exception of the heart rate rise. Conclusions. In a larger group of subjects, the psychosocial stress test did elicit stress responses similar to the individual stress tests. Our data indicate that the above-mentioned stress test is apparently not an appropriate approach for the repeated use.

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Section: Discussioncontrasting

confidence: 99%

Neuroendocrine responses to a psychosocial stress test for larger groups of participants: comparison of two test exposures

Rajčáni

Soláriková

Brezina

et al. 2020

Endocrine Regulations

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“…Morning cortisol concentrations in remitters negatively correlated with trait anxiety. These results are consistent with our previous studies demonstrating an association between high trait anxiety and low cortisol responses [49-51]. No associations between salivary aldosterone and personality characteristics were observed in remitted patients.…”

Section: Discussionsupporting

confidence: 93%

Salivary Aldosterone, Cortisol, and Their Morning to Evening Slopes in Patients with Depressive Disorder and Healthy Subjects: Acute Episode and Follow-Up 6 Months after Reaching Remission

et al. 2020

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Background/Objective: Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course of clinical depression with the assumption that aldosterone is a state marker of depression. Methods: A total of 78 adult subjects (39 patients with depressive disorder and 39 healthy controls) participated in a prospective non-interventional clinical study. Patients were investigated at the time of an acute episode and 6 months after reaching remission. The clinical and personal characteristics, and morning and evening salivary concentrations of aldosterone and cortisol were evaluated. Results: Patients with an acute depressive episode exhibited higher evening aldosterone and lower morning cortisol concentrations compared to healthy subjects. In these patients, both hormone concentrations showed flatter morning to evening slopes. Salivary aldosterone, but not cortisol concentrations, were lower in patients 6 months after reaching remission compared to those in the acute state. Similarly, 6 months of remission resulted in a steeper morning to evening slope of salivary aldosterone compared to the acute state. The cortisol rhythm remained dysregulated. A significant negative correlation between trait anxiety scores and morning cortisol concentrations in patients at 6 months of clinical remission was observed. Conclusion: Diurnal changes in salivary aldosterone concentrations appear to be a state marker, whilst those of cortisol a trait marker of depression.

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“…In earlier research, it was observed that atopic dermatitis (AD) patients had lower morning salivary cortisol values than HCs, especially in those with severe AD, and a negative correlation between acute stress-associated increased salivary cortisol levels and AD severity was found. 5,8,9 Similarly, lower morning salivary cortisol levels were found in our CHD patients compared to HCs. It is likely that our CHD patients were exposed to chronic PS.…”

Section: Discussionsupporting

confidence: 67%

Salivary cortisol and perceived psychological stress in patients with chronic contact hand dermatitis

Pondeljak,

Lucija,

Elvira

et al. 2023

Contact Dermatitis

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Patients with atopy exhibit reduced cortisol awakening response but not cortisol concentrations during the rest of the day

Cited by 5 publications

References 36 publications

Neuroendocrine responses to a psychosocial stress test for larger groups of participants: comparison of two test exposures

Neuroendocrine responses to a psychosocial stress test for larger groups of participants: comparison of two test exposures

Salivary Aldosterone, Cortisol, and Their Morning to Evening Slopes in Patients with Depressive Disorder and Healthy Subjects: Acute Episode and Follow-Up 6 Months after Reaching Remission

Salivary cortisol and perceived psychological stress in patients with chronic contact hand dermatitis

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