Patients with asthma have a higher risk of rheumatoid arthritis: A systematic review and meta-analysis

Charoenngam, Nipith; Ponvilawan, Ben; Rittiphairoj, Thanitsara; Tornsatitkul, Surapa; Wattanachayakul, Phuuwadith; Rujirachun, Pongprueth; Ungprasert, Patompong

doi:10.1016/j.semarthrit.2020.07.015

Cited by 24 publications

(21 citation statements)

References 53 publications

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“…For example, broader immune system dysregulation could predispose to both respiratory tract diseases and RA, with the respiratory tract diseases simply manifesting first. However, even non-infectious respiratory tract diseases like asthma (5)(6)(7)(8)(9)(10)(11)(12) and COPD (6,13,14) have been consistently shown to be associated with RA. Furthermore, respiratory tract diseases including asthma (37), COPD (38), and interstitial lung disease (39) have been shown to generate ACPA.…”

Section: Accepted Articlementioning

confidence: 99%

“…Exposure to toxins like silica and coal has also been established as a risk for RA. (1,3,4) Chronic lower respiratory tract disease such as asthma (5)(6)(7)(8)(9)(10)(11)(12) and chronic obstructive pulmonary disease (COPD) are also established risk factors for RA (6,13,14). A recent case-control study from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) in Sweden suggested that not only chronic lower respiratory tract diseases like asthma and COPD, but also acute respiratory tract diseases and chronic upper respiratory tract diseases were associated with increased risk of incident RA (15).…”

Section: Introductionmentioning

confidence: 99%

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Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study

et al. 2021

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Objective We aimed to determine whether specific respiratory tract diseases are associated with increased rheumatoid arthritis (RA) risk. Methods This case-control study within the Mass General Brigham Biobank matched newly diagnosed RA cases to three controls on age, sex, and electronic health record history. We identified RA using a validated algorithm and confirmed by medical record review. Respiratory tract disease exposure required one inpatient or two outpatient codes at least two years before index date of RA clinical diagnosis or matched date. Logistic regression models calculated odds ratios (OR) for RA with 95% confidence intervals (CI), adjusting for confounders. We then stratified by serostatus ("seropositive" was positive rheumatoid factor and/or anti-citrullinated protein antibodies) and smoking. Results We identified 741 RA cases and 2,223 controls (both median age 55, 76% female). Acute sinusitis (OR 1.61, 95% CI:1.05,2.45), chronic sinusitis (OR 2.16, 95% CI:1.39,3.35), and asthma (OR 1.39, 95% CI:1.03,1.87) were associated with increased risk of RA. Acute respiratory tract disease burden during the pre-index exposure period was also associated with increased RA risk (OR 1.30 per 10 codes, 95% CI:1.08,1.55). Acute pharyngitis was associated with seronegative (OR 1.68, 95% CI:1.02,2.74) but not seropositive RA; chronic rhinitis/pharyngitis was associated with seropositive (OR 2.46, 95% CI:1.01,5.99) but not seronegative RA. Respiratory tract diseases tended towards higher associations in smokers, especially >10 packyears (OR 1.52, 95% CI:1.02,2.27; p=0.10 for interaction). Conclusion Acute/chronic sinusitis and pharyngitis and acute respiratory burden increased RA risk. The mucosal paradigm of RA pathogenesis may involve the upper respiratory tract.

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Section: Accepted Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study

et al. 2021

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“…Inflammatory bowel disease (IBD) and rheumatoid arthritis are both autoimmune diseases, and pertussis is an acute respiratory infectious disease. It is currently believed that allergy is a nonlocalized chronic inflammatory disease, which can lead to systemic immune dysfunction and further increase the risk of irritable bowel syndrome, rheumatoid arthritis, and pertussis [56][57][58][59]. e IL-17 signaling pathway, which enriches most of the central targets, is presumed to be the most relevant pharmacodynamic pathway of YPFP.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases

Tao

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the potential mechanisms of Yupingfeng Powder (YPFP) in the treatment of allergic diseases by using network pharmacology and molecular docking technology. Methods. The active components and targets of YPFP were screened by the TCMSP database. The targets associated with atopic dermatitis, asthma, allergic rhinitis, and food allergy were obtained from GeneCards and OMIM databases, respectively. The intersection of the above disease-related targets was identified as allergy-related targets. Then, allergy-related targets and YPFP-related targets were crossed to obtain the potential targets of YPFP for allergy treatment. A protein-protein-interaction (PPI) network and a drug-target-disease topology network were constructed to screen hub targets and key ingredients. Next, GO and KEGG pathway enrichment analyses were performed separately on the potential targets and hub targets to identify the biological processes and signaling pathways involved. Finally, molecular docking was conducted to verify the binding affinity between key ingredients and hub targets. Results. In this study, 45 active ingredients were identified from YPFP, and 48 allergy-related targets were predicted by network pharmacology. IL6, TNF, IL1B, PTGS2, CXCL8, JUN, CCL2, IL10, IFNG, and IL4 were screened as hub targets by the PPI network. However, quercetin, kaempferol, wogonin, formononetin, and 7-O-methylisomucronulatol were identified as key ingredients by the drug-target-disease topological network. GO and KEGG pathway enrichment analysis indicated that the therapeutic effect of YPFP on allergy involved multiple biological processes and signaling pathways, including positive regulation of fever generation, positive regulation of neuroinflammatory response, vascular endothelial growth factor production, negative regulation of cytokine production involved in immune response, positive regulation of mononuclear cell migration, type 2 immune response, and negative regulation of lipid storage. Molecular docking verified that all the key ingredients had good binding affinity with hub targets. Conclusion. This study revealed the key ingredients, hub targets, and potential mechanisms of YPFP antiallergy, and these data can provide some theoretical basis for subsequent allergy treatment and drug development.

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“…In both asthma and SLE patients, elevated levels of TH2 class cytokines, including as IL-4, IL-5, and IL-13, have been found. Furthermore, people with SLE have been found to have higher levels of total IgE, which is commonly related with asthma and allergic diseases (Charoenngam et al, 2020).…”

Section: Subjects Characteristicsmentioning

confidence: 99%

The Correlation between Allergic Diseases and Systemic Lupus Erythematosus

Pratiwi

Werdiningsih²,

Matea³

et al. 2022

INDONES J MED

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Background:The prevalence of autoimmune diseases and major chronic allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis are increasing in line with the occurrence of climate change. Allergy and systemic lupus erythematosus (SLE) are sometimes being linked since both are immune diseases involving gene-environment interactions. The purpose of this research is to investigate the correlation between allergic diseases and SLE. Method: This case-control study was performed on 39 SLE subjects from the Tittari Community and 39 non-SLE subjects aged 15-49 years old, from September until October 2021. All of them were females. The independent variable was allergic disease and the dependent variable was SLE. Participants' characteristics and allergy data were collected through answering the online Score for Allergic Rhinitis (SFAR) questionnaire, then the results were processed with bivariate and multivariate analyses. Results:The correlation between allergic diseases and SLE was significant for atopic dermatitis but not for allergic rhinitis and asthma (p=0.018; p=0.352; p=0.151 respectively). The bivariate analysis revealed that the risk of SLE was 3.17 times higher in atopic dermatitis patients (OR=3.17; 95% CI=1.20-8.39; p=0.018). Furthermore, the multivariate analysis found that subjects with atopic dermatitis had the highest risk of SLE (OR= 3.18; 95% CI= 1.07-9.51; p=0.031). Conclusion: Among allergic diseases, atopic dermatitis was found to be significantly correlated with SLE, where the risk of SLE was raised as the number of atopic dermatitis increased.

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Patients with asthma have a higher risk of rheumatoid arthritis: A systematic review and meta-analysis

Cited by 24 publications

References 53 publications

Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study

Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study

Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases

The Correlation between Allergic Diseases and Systemic Lupus Erythematosus

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