Patients with arterial hypertension and COVID-19 are at higher risk of ICU admission

Roncon, Loris; Zuin, Marco; Zuliani, Giovanni; Rigatelli, Gianluca

doi:10.1016/j.bja.2020.04.056

Cited by 35 publications

(28 citation statements)

References 8 publications

(8 reference statements)

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“…First, a previous study suggests that antihypertensive drugs may increase the expression of ACE2—a protein that is paramount for SARS-CoV-2 viral infection [4]. Second, there is high mortality in patients with cardiovascular complications [ [13] , [14] , [15] , [16] ].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have reported high mortality in patients with cardiovascular complications [ [12] , [13] , [14] , [15] ]. Our results suggest that taking antihypertensive medications did not increase the incidence or severity of COVID-19 in patients taking antihypertensive medications.…”

Section: Discussionmentioning

confidence: 99%

“…Previous evidence has suggested that antihypertensive drugs such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) can elevate ACE2 expression [ [8] , [9] , [10] ], which may increase susceptibility to and worsen the prognosis of COVID-19. Due to the high prevalence of COVID-19 in patients with preexisting cardiovascular conditions such as hypertension [ [13] , [14] , [15] , [16] ], coronary artery disease, and congestive heart failure [ 17 ], the usage of these antihypertensive drugs warrants great concerns. Indeed, controversy remains regarding the usage of these antihypertensive medications on the vulnerable population.…”

Section: Introductionmentioning

confidence: 99%

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Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis

Ren

et al. 2021

Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis

Ren

et al. 2021

Journal of Cardiology

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“…Hypertension has been associated with mortality risk since early reports on COVID-19 cases confirmed this in China; this association was replicated in subsequent studies. [34,35] Hypertension alters ACE2 expression, increases the risk of cardiovascular and renal failure, and may cause organ damage; thus, the detrimental effect of hypertension on COVID-19 outcomes seems biologically plausible. [36] However, it remains unclear whether hypertension is an independent rather than a confounding factor for severe COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: A matter of sexual dimorphism?

Huh

Lee

Kang

et al. 2020

Diabetes Research and Clinical Practice

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…However, it is noted that further studies of other comorbidities either linked or not linked to hypertension are needed. Also, Roncon et al [47] looked at the rate of ICU admission of COVID-19 patients with hypertension. They found that among the 1382 patients (mean age ¼ 51.5 years, 57.74% males), patients with hypertension had a significantly increased risk of ICU admission (OR ¼ 2.54; 95% CI: 1.83e3.54; P < 0.0001).…”

Section: High-blood Pressure and Hypertensionmentioning

confidence: 99%

Association of hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality: A systematic review

Zaki¹,

Alashwal²,

Ibrahim³

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

209

112

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Background and aims: To undertake a review and critical appraisal of published/preprint reports that offer methods of determining the effects of hypertension, diabetes, stroke, cancer, kidney issues, and high-cholesterol on COVID-19 disease severity. Methods: A search was conducted by two authors independently on the freely available COVID-19 Open Research Dataset (CORD-19). We developed an automated search engine to screen a total of 59,000 articles in a few seconds. Filtering of the articles was then undertaken using keywords and questions, e.g. "Effects of diabetes on COVID/normal coronavirus/SARS-CoV-2/nCoV/COVID-19 disease severity, mortality?". The search terms were repeated for all the comorbidities considered in this paper. Additional articles were retrieved by searching via Google Scholar and PubMed. Findings: A total of 54 articles were considered for a full review. It was observed that diabetes, hypertension, and cholesterol levels possess an apparent relation to COVID-19 severity. Other comorbidities, such as cancer, kidney disease, and stroke, must be further evaluated to determine a strong relationship to the virus. Conclusion: Reports associating cancer, kidney disease, and stroke with COVID-19 should be carefully interpreted, not only because of the size of the samples, but also because patients could be old, have a history of smoking, or have any other clinical condition suggesting that these factors might be associated with the poor COVID-19 outcomes rather than the comorbidity itself. Further research regarding this relationship and its clinical management is warranted.

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Patients with arterial hypertension and COVID-19 are at higher risk of ICU admission

Cited by 35 publications

References 8 publications

Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis

Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis

Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: A matter of sexual dimorphism?

Association of hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality: A systematic review

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