Patients’ Preferences for Treatment for Dupuytren’s Disease

Kan, Hester J.; Bekker‐Grob, Esther W. de; Marion, Eva S van; Oijen, Guido W. Van; Nieuwenhoven, Christianne A. van; Zhou, Chao; Hovius, Steven E.R.; Selles, Ruud W.

doi:10.1097/prs.0000000000001878

Cited by 33 publications

(21 citation statements)

References 21 publications

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“…And the goal should be to greatly reduce or even eliminate recurrences. This is in accordance with the statements by patients who say what they are seeking are treatment options offering low rates of recurrence, complete finger extension, and minimal convalescence [6].…”

Section: Introductionsupporting

confidence: 89%

Prevention of Recurrences in Dupuytren’s Contracture: Are We in the Right Side?

Sanjuán-Cerveró

2019

SN Compr. Clin. Med.

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Dupuytren contracture is a fibroproliferative disorder affecting the palm of the hand causing a sustained flexion of the fingers due to fibrous cord contracture. Collagenase clostridium histolyticum, as pharmacological treatment, achieves the selective degradation of a portion of the cord, thus enabling the affected finger's functionality. Our hypothesis is based on a literary review looking for associations based on collagenase for the treatment of the Dupuytren's disease. Current treatment options for Dupuytren's are symptomatic and aim at removing part of the affected tissue to restore hand functionality. Recurrence remains the greatest challenge for achieving long-term successful treatment. The association of a hydrogel with the collagenase increases the action time of the latter. The association to a collagenase-hydrogel complex with a third drug (anti-TGFß) acting at the unstructured extracellular matrix in the proliferative phase of the response of wound healing that takes place after the administration of collagenase for direct action on the transformation of fibroblast into myofibroblast, thus resembling as far as possible the actions drugs have on cell cultures. However, in Dupuytren's contracture, the breakage and degradation of the cord that occur with current treatment make this increase in local action time unnecessary. Combining actual treatment options in Dupuytren's disease with a hydrogel acting as a vehicle can provide an alternative to destroy the extracellular matrix and act directly against the myofibroblast.

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Section: Introductionsupporting

confidence: 89%

Prevention of Recurrences in Dupuytren’s Contracture: Are We in the Right Side?

Sanjuán-Cerveró

2019

SN Compr. Clin. Med.

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“…Further research is warranted in this area, which we believe can address a knowledge gap regarding the concerns and needs that influence treatment decision-making among patients with Dupuytren’s disease. 28 – 30 …”

Section: Discussionmentioning

confidence: 99%

“…A second limitation is that we could not reliably assess rates of recurrence, which may be as relevant to patients in treatment decision-making as early outcomes, because of the limited time-horizon of our study. 30 Third, only a subset of patients completed the MHQ. Although this might have influenced our results, the possibility for attrition bias seems small because there were no differences in the characteristics between those who did and did not complete the MHQ at follow-up.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effectiveness of Needle Aponeurotomy and Collagenase Injection for Dupuytren’s Contracture: A Multicenter Study

Zhou

Hovius

Pieters

et al. 2017

Plastic and Reconstructive Surgery - Global Open

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“…In the present study, clients' need for knowledge was closely connected to being involved in making decisions regarding treatment; these could be decisions about treatment options or the anaesthetic procedure. It has been shown in a recent study that there is substantial heterogeneity in clients' preferences for different treatment options, which can be addressed by shared decision-making (18). However, the present study shows that not all clients may be comfortable with being involved in making decisions, especially concerning specific medical decisions such as the anaesthetic procedure.…”

Section: Discussionmentioning

confidence: 54%

Patients’ needs during a surgical intervention process for Dupuytren’s disease

Turesson

Kvist

Krevers

2017

Disability and Rehabilitation

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Clients' needs during a surgical intervention process include needs for improvement of hand function, knowledge, and support during treatment, and participation in evaluation. Clients' needs change during the care process and can be influenced by their life situation or their character. The identified needs ought to be included in quality assessments from the carers' perspective, to ensure that important needs of the clients are met by the surgical intervention process. Communication and interaction between client and health care provider is a key aspect of fulfilling clients' needs. Implications for rehabilitation Patients have need for knowledge throughout the care process: about the disease, risk factors, treatment options, practical and medical information related to the treatment and recovery, and about the care process as a whole. Need for knowledge is closely connected to patients' experience of being involved in decision making. Patients need support with both general human and specific medical issues during surgery and rehabilitation. Patients' needs change during the care process and can be influenced by the patient's life situation or character. From the carers' perspective, the identified needs ought to be included in quality assessments to ensure that important needs of the clients are met by the surgical intervention process.

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Patients’ Preferences for Treatment for Dupuytren’s Disease

Cited by 33 publications

References 21 publications

Prevention of Recurrences in Dupuytren’s Contracture: Are We in the Right Side?

Prevention of Recurrences in Dupuytren’s Contracture: Are We in the Right Side?

Comparative Effectiveness of Needle Aponeurotomy and Collagenase Injection for Dupuytren’s Contracture: A Multicenter Study

Patients’ needs during a surgical intervention process for Dupuytren’s disease

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