Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment

Sculpher, Mark; Bryan, Stirling; Fry, Pat; Winter, Patricia de; Payne, Heather; Emberton, M

doi:10.1136/bmj.37972.497234.44

Cited by 127 publications

(118 citation statements)

References 10 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…This DCE has helped advance the understanding of how patients and physicians make choices about second-line therapy and it has contributed to the DCE literature which focuses on eliciting preference for cancer therapies. [22][23][24] For both patients and physicians, survival free of relapse was an important positive influence on choice. Toxicity of allo-SCT relative to standard CT was an important negative influence on choice.…”

Section: Discussionmentioning

confidence: 99%

Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment

Shafey

Lupichuk

et al. 2010

Bone Marrow Transplant

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment

Shafey

Lupichuk

et al. 2010

Bone Marrow Transplant

View full text Add to dashboard Cite

“…3 Most participants preferred non-steroidal anti-androgen therapy compared with LHRH agonist therapy, primarily because of the relative side effect profiles. Sculpher et al 4 report a discrete choice experiment (DCE) of patient preferences for conservative treatment in early-stage (non-metastatic) prostate cancer. This study explored the importance of diarrhoea, hot flushes, ability to maintain an erection, breast swelling or tenderness, physical energy, sex drive, life expectancy and out-of-pocket cost in 129 men with T stage 1 or 2 (non-metastatic) disease at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Eliciting patient preferences for hormonal therapy options in the treatment of metastatic prostate cancer

Lloyd

Penson

Dewilde³

et al. 2007

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Treatment choices for metastatic prostate cancer are complex and can involve men balancing survival versus quality of life. The present study aims to elicit patient preferences with respect to the attributes of treatments for metastatic prostate cancer through a discrete choice experiment (DCE) questionnaire. Men with recently diagnosed localized prostate cancer were asked to envisage that they had metastatic disease when completing a survey. As expected, men with prostate cancer placed considerable importance on gains in survival; however, avoiding side effects of treatment was also clearly important. Survival gains should be considered alongside side effects when discussing treatment options in metastatic disease.

show abstract

“…Discrete choice experiments (DCEs) are becoming more widely used in health-care research (Gyrd-Hansen and Sogaard, 2001;Sculpher et al, 2004;Marshall et al, 2007Marshall et al, , 2009Hur et al, 2008). A DCE is capable of establishing preferences and to predict uptake in controlled experimental conditions, through responses to realistic and hypothetical scenarios.…”

mentioning

confidence: 99%

Preferences for colorectal cancer screening strategies: a discrete choice experiment

et al. 2010

View full text Add to dashboard Cite

BACKGROUND: Guidelines underline the role of individual preferences in the selection of a screening test, as insufficient evidence is available to recommend one screening test over another. We conducted a study to determine the preferences of individuals and to predict uptake for colorectal cancer (CRC) screening programmes using various screening tests. METHODS: A discrete choice experiment (DCE) questionnaire was distributed among naive subjects, yet to be screened, and previously screened subjects, aged 50 -75 years. Subjects were asked to choose between scenarios on the basis of faecal occult blood test (FOBT), flexible sigmoidoscopy (FS), total colonoscopy (TC) with various test-specific screening intervals and mortality reductions, and no screening (opt-out). RESULTS: In total, 489 out of 1498 (33%) screening-naïve subjects (52% male; mean age±s.d. 61±7 years) and 545 out of 769 (71%) previously screened subjects (52% male; mean age±s.d. 61±6 years) returned the questionnaire. The type of screening test, screening interval, and risk reduction of CRC-related mortality influenced subjects' preferences (all Po0.05). Screening-naive and previously screened subjects equally preferred 5-yearly FS and 10-yearly TC (P ¼ 0.24; P ¼ 0.11), but favoured both strategies to annual FOBT screening (all P-values o0.001) if, based on the literature, realistic risk reduction of CRC-related mortality was applied. Screening-naive and previously screened subjects were willing to undergo a 10-yearly TC instead of a 5-yearly FS to obtain an additional risk reduction of CRC-related mortality of 45% (Po0.001). CONCLUSION: These data provide insight into the extent by which interval and risk reduction of CRC-related mortality affect preferences for CRC screening tests. Assuming realistic test characteristics, subjects in the target population preferred endoscopic screening over FOBT screening, partly, due to the more favourable risk reduction of CRC-related mortality by endoscopy screening. Increasing the knowledge of potential screenees regarding risk reduction by different screening strategies is, therefore, warranted to prevent unrealistic expectations and to optimise informed choice.

show abstract

Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment

Abstract: severity differed between attributes, marginal rates of substitution between attributes should be compared with caution. The most important marginal rates of substitution were for physical energy.

Cited by 127 publications

References 10 publications

Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment

Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment

Eliciting patient preferences for hormonal therapy options in the treatment of metastatic prostate cancer

Preferences for colorectal cancer screening strategies: a discrete choice experiment

Contact Info

Product

Resources

About