Patients preferences for different corticosteroid vehicles are highly variable

Felix, Kayla; Unrue, Emily L; Inyang, Meyene; Cardwell, Leah A.; Oussedik, Elias; Richardson, Irma; Feldman, Steven R.

doi:10.1080/09546634.2018.1473837

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…In a clinical study aimed at establishing the patient’s preference among several topical corticosteroids, Felix et al, identifies an extensive variability, confirming the need to individualize the treatment. Subjects expressed the greatest concern for the absorption, messiness, feel on skin, and stains on fabrics; cost and side effects were the two most influential Determinants of Adherence and Quality of Life [ 57 ]. More recently, an indirect analysis comparing comments on the use of Cal/BD cream and foam showed that treatment with Cal/BD cream was associated with significantly greater satisfaction on the overall treatment vs. the foam since the cream resulted in ‘ease of application’, ‘not greasy’, and ‘felt moisturizing’ [ 58 ].…”

Section: Topical Vehicles and Patient’s Preferencesmentioning

confidence: 99%

Spotlight on Calcipotriol/Betamethasone Fixed-Dose Combination in Topical Formulations: Is There Still Room for Innovation?

et al. 2022

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Psoriasis is a lifelong disease which requires treatment adherence for successful management. Considering the complexity of this pathology, the combination of active pharmaceutical ingredients with a synergistic mechanism of action can improve the safety and efficacy of the treatment with respect to the conventional monotherapy. Moreover, a fixed dose of therapeutic agents in a topical formulation offers the possibility to simplify administration, reduce the doses of each active ingredient, and improve patient’s compliance. Among the first-line treatments in mild to moderate psoriasis, the formulation of calcipotriol (Cal) and betamethasone dipropionate (BD) in a single vehicle is challenging due to their chemical incompatibility in an aqueous environment and the formation of degradation products. Based on these considerations, this review aims to provide an overview on the biopharmaceutical properties of Cal/BD fixed-dose combination products available on the market (namely ointment, oleogel, foam, and O/W cream), highlighting also the novel approaches under evaluation. The main differences among topical formulations are discussed considering the different features of the anatomic districts involved in psoriasis and the patient’s adherence. Moreover, since in vitro experiments are fundamental to evaluate the skin permeation profile during the development of an efficacious medicinal product, special emphasis is given to models proposed to mimic psoriatic lesions.

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Section: Topical Vehicles and Patient’s Preferencesmentioning

confidence: 99%

Spotlight on Calcipotriol/Betamethasone Fixed-Dose Combination in Topical Formulations: Is There Still Room for Innovation?

et al. 2022

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“…Topikalna terapija kortikosteroidima je u drugoj polovini XX veka brzo i dobro prihvaćena od strane pacijenata jer je bila efikasna, jednostavnija za primenu i kozmetski prihvatljivija od prethodnih modaliteta (katrana, antralina), bez neprijatnog mirisa, oštećenja tkanina (odeće, posteljine), intenziviranja simptoma iritacije kože. Farmaceutska industrija razvila je brojne formulacije za primenu topikalne kortikosteroidne terapije, ali informacije o afinitetu pacijenata prema vrstama vehikuluma, kao i uticaju na adherenciju sa terapijom su oskudne 19,20 . Neoptimalna adherencija sa terapijom dovodi do neuspeha lečenja, nepovoljnih kliničkih ishoda, povećanja troškova.…”

Section: Afiniteti Pacijenata Prema Formulacijama Topikalnih Kortikos...unclassified

Corticosteroid topical therapy range: Fluocinolone-acetonide gel

Gajinov¹

2022

Galenika Med J

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Since the early days of use, in the mid of twentieth century, topical corticosteroids became the basis of contemporary dermatological therapy, because of their antiinflammatory efficiency, comfort of application free from unpleasant characteristics of previous generations of dermatotherapeutics, tar or antralin. With numerous evidences about potencies of specific corticosteroid molecules for adverse effects, optimal and efficient use of topical corticosteroid is the empiric art of dermatology, based on precise diagnosis, knowledge about the pathophysiology of dermatosis and characteristics of topical medication, and good communication with patients to promote optimal use of therapy. There are numerous strategies for optimization of skin atrophy risk and suboptimal therapeutic efficacy, caused by too restrictive topical drug use. Preferences of patients with chronic dermatoses are an important factor for good adherence with therapy, generally favoring formulations that are easier for application, less occlusive and less time-consuming. In most medical systems Fluocinolon gel is topical steroid formulation continuously present from the early days of use. It is adequate for use both for glabrous and hair-bearing skin and for oral mucosa also. A long history of use, the knowledge about effiancy and adverse effects make fluocinolone gel the important part of topical corticosteroid palette, parallel with new modern formulations.

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“…For example, one study found that preference for corticosteroid vehicles among psoriasis patients was highly variable and choice of vehicle was critical to adherence. 6 Another study highlighted differences in vehicle choice between younger and older age groups with psoriasis. 7 Given the limited data overall, it was our goal to determine if any patterns of preference existed by age, gender, or ethnicity, regardless of disease state or indication for topical product.…”

Section: Commentmentioning

confidence: 99%

Variations in Preference for Topical Vehicles Among Demographic Groups

Figenshau¹,

Kimmis²,

Reicherter³

2020

Cutis

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Patient satisfaction and outcomes can be optimized by identifying preferences for topical vehicles by age, gender, and ethnicity. Our study sought to identify variations in preferences for creams, lotions, and ointments among different age groups, genders, and ethnicities. Each demographic group revealed statistically significant differences in vehicle preference (P<.05). Cutis. 2020;106:40-43. T opical medication is a mainstay in the treatment of dermatologic conditions. Adherence to medication regimens can be challenging in patients requiring long-term topical treatment, and nonadherence is multifactorial. A major modifiable contributing factor is patient dissatisfaction with the vehicle used. Medications often have options for different topical preparations. Therefore, it is important to consider patient preference when prescribing topical treatments to maximize adherence, ensure patient satisfaction, and optimize outcomes. We hypothesized that notable differences exist among demographic groups regarding preference for topical vehicles. Little research has been conducted to delineate trends. This study aimed to identify variations in preference for creams, lotions, and ointments by age, gender, and ethnicity. Methods Data were collected through surveys distributed to all patients seen at the Truman Medical Center University Health Dermatology Clinic in Kansas City, Missouri, between September 2018 and June 2019. The study was approved by the University of Missouri Kansas City institutional review board. An estimated response rate of 95% was achieved. Each patient was informed that the survey was voluntary and anonymous, and declining to complete the survey had no effect on the care provided. Each patient completed only 1 survey and returned it to a collection box before departing from clinic. In the survey, patients provided demographic information, including age, gender, and ethnicity. Age groups included patients younger than 40 years, 40 to 60 years, and older than 60 years. Gender groups included male and female. Ethnicity included white, black, Hispanic/ Latino, and Asian/Pacific Islander or other. Patients then chose 1 of 3 options for topical vehicle preference: cream, lotion, or ointment. Each of these options was accompanied by a brief description of the vehicle, a photograph, and examples of common commercial products to aid in decision-making. The expected values were calculated based on a probability distribution under the assumption that variables have no association. Therefore, the discrepancy between the expected value and the observed value

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Patients preferences for different corticosteroid vehicles are highly variable

Cited by 14 publications

References 9 publications

Spotlight on Calcipotriol/Betamethasone Fixed-Dose Combination in Topical Formulations: Is There Still Room for Innovation?

Spotlight on Calcipotriol/Betamethasone Fixed-Dose Combination in Topical Formulations: Is There Still Room for Innovation?

Corticosteroid topical therapy range: Fluocinolone-acetonide gel

Variations in Preference for Topical Vehicles Among Demographic Groups

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