Patients' Preference for Migraine Preventive Therapy

Peres, Mário Fernando Prieto; Silberstein, Stephen D.; Moreira, Frederico Rafael; Corchs, Felipe; Vieira, Domingos Savio; Abraham, Nina; Gebeline-Myers, Cheryl

doi:10.1111/j.1526-4610.2007.00757.x

Cited by 86 publications

(99 citation statements)

References 11 publications

(11 reference statements)

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“…Most commonly prescribed prophylactic medications in Spanish prevention studies are topiramate, amitriptyline, propranolol and flunarizine [22], a similar finding to our study. However, a study performed in a headache center from an urban Brazilian population reported the frequent use of vitamins/herbal therapies (24%), and non-medicinal therapy (32%) to prevent migraine [23]. Frequent use of non-pharmacological measures in the Brazilian population suggests an under-utilization of efficacious preventive drugs.…”

Section: Discussionmentioning

confidence: 97%

Triggers, symptoms, and treatment in two populations of migraneurs in Brazil and Spain. A cross-cultural study

Carod-Artal¹,

Ezpeleta²,

Martín-Barriga³

et al. 2011

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 97%

Triggers, symptoms, and treatment in two populations of migraneurs in Brazil and Spain. A cross-cultural study

Carod-Artal¹,

Ezpeleta²,

Martín-Barriga³

et al. 2011

Journal of the Neurological Sciences

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“…Comments: The choice of 50% or greater reduction is arbitrary yet clinically relevant as most patients with migraine value 50% improvement in headache frequency as the most important attribute of an effective migraine preventive drug (131).…”

Section: Responder Ratementioning

confidence: 99%

Guidelines for controlled trials of drugs in migraine: Third edition. A guide for investigators

Tfelt‐Hansen

Pascual

Ramadan³

et al. 2012

Cephalalgia

315

213

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“…It is well understood that patients who suffer from migraine are burdened by factoring in considerations to accommodate impending migraine attacks. The disruptions to work, family, and social activities caused by migraine translate into an overall poorer quality of life 13, 20. In this study, patients who had at least 1 month of 100% response had more freedom from their migraine headaches across the 6‐month dosing period.…”

Section: Discussionmentioning

confidence: 99%

100% Response Rate to Galcanezumab in Patients With Episodic Migraine: A Post Hoc Analysis of the Results From Phase 3, Randomized, Double‐Blind, Placebo‐Controlled EVOLVE‐1 and EVOLVE‐2 Studies

et al. 2018

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ObjectiveTo characterize adult patients with episodic migraine who achieved 100% response to galcanezumab treatment.BackgroundGalcanezumab is a humanized monoclonal antibody that selectively binds to the calcitonin gene‐related peptide (CGRP) and has demonstrated efficacy in reducing migraine headache days (MHD) in patients with episodic and chronic migraine.MethodsA post hoc analysis of the proportion of patients with 100% response (100% reduction from baseline in monthly MHD) was calculated for each month from pooled data of 2 double‐blind, 6‐month galcanezumab studies in patients with episodic migraine (4 to 14 MHD and ≥2 migraine attacks per month at baseline). The patients were randomized (1:1:2) to monthly subcutaneous galcanezumab, 120 mg (after 240 mg initial loading dose) or 240 mg, or placebo. A generalized linear mixed model with effects for baseline MHD, treatment, month, and treatment‐by‐month interaction was used to estimate the mean monthly response rate.ResultsThe analysis included 1739 patients treated with galcanezumab, 120 mg (n = 436) or 240 mg (n = 428), or placebo (n = 875). The mean monthly 100% response rate on an average month in the 6‐month double‐blind phase was greater for galcanezumab 120 mg (13.5%) and 240 mg (14.3%) groups vs placebo (5.9%) with odds ratios of 2.5 (95% confidence interval [CI] 1.9, 3.2) and 2.6 (95% CI 2.0, 3.4), respectively (P < .001). The rate of 100% monthly response increased at each month over the 6‐month double‐blind phase with higher rates for galcanezumab dose groups (9 to 21%) than placebo (2 to 10%) (P < .02). Evaluation of 100% response by the number of months showed a greater proportion of galcanezumab‐treated patients in either dose group, compared to placebo, were able to achieve a 100% response (P < .001 up to 3 months); however, though greater than placebo, few galcanezumab patients had ≥4 months of 100% response (P < .02). The proportions of patients with 100% response were greatest in the last 3 months of the treatment. Considering the average number days between nonconsecutive MHD across the 6‐month period (not just during the times of 100% response), the duration of migraine headache‐free periods in the galcanezumab groups was 29 days for those with at least 1 month of 100% response and 55 days for those with at least 3 months of 100% response. This gap was approximately 6 to 11 times greater than the mean gap of 5 days observed at baseline.ConclusionsMore than a third of the patients with episodic migraine treated with galcanezumab 120 mg or 240 mg achieved 100% response for at least 1 month. More patients had 100% monthly response in the last 3 months of the 6‐month double‐blind period. For those with 100% response for at least 1 month, the average time between nonconsecutive MHD for the entire treatment period was nearly 1 month and approached 2 months for patients with 3 or more months of 100% response.

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Patients' Preference for Migraine Preventive Therapy

Cited by 86 publications

References 11 publications

Triggers, symptoms, and treatment in two populations of migraneurs in Brazil and Spain. A cross-cultural study

Triggers, symptoms, and treatment in two populations of migraneurs in Brazil and Spain. A cross-cultural study

Guidelines for controlled trials of drugs in migraine: Third edition. A guide for investigators

100% Response Rate to Galcanezumab in Patients With Episodic Migraine: A Post Hoc Analysis of the Results From Phase 3, Randomized, Double‐Blind, Placebo‐Controlled EVOLVE‐1 and EVOLVE‐2 Studies

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