Patients’ exposure to PVC plasticizers from ECMO circuits

Fernandez-Canal, Charlotte; Pinta, Pierre-Gabriel; Eljezi, Teuta; Larbre, Virginie; Kauffmann, S.; Camilleri, Lionel; Cosserant, Bernard; Bernard, Lise; Pereira, Bruno; Constantin, Jean-Michel; Grimandi, G.; Sautou, V.

doi:10.1080/17434440.2018.1462698

Cited by 17 publications

(19 citation statements)

References 18 publications

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“…To our knowledge, with the exception of our previous work [2], there are no published studies concerning the release of these new plasticizers from the MD and into the patient. Four studies on the leaching of TOTM from tubings, dialysis or ECMO lines suggest that the release of this alternative plasticizer remains lower than DEHP [3][4][5][6]. The only available study on DINCH release, investigated leaching from PVC tubes into enteral feeding solutions, was funded by Nutricia (for review [7]).…”

Section: Introductionmentioning

confidence: 99%

New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices

Pinguet

Kerckhove

Eljezi

et al. 2019

Talanta

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Introductionmentioning

confidence: 99%

New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices

Pinguet

Kerckhove

Eljezi

et al. 2019

Talanta

Self Cite

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“…Toxicity is one of the majors health concerns associated with plasticizers routinely used in common “plastics” [52]. Actually, in this context, legislators have banned DEHP from toys and childcare articles [7].…”

Section: Resultsmentioning

confidence: 99%

Replacing Di(2-ethylhexyl) Terephthalate by Di(2-ethylhexyl) 2,5-Furandicarboxylate for PVC Plasticization: Synthesis, Materials Preparation and Characterization

et al. 2019

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The worldwide regulatory demand for the elimination of non-phthalate compounds for poly(vinyl chloride) (PVC) plasticization has intensified the search for alternatives. Concomitantly, sustainability concerns have highlighted sugar-based 2,5-furandicarboxylic acid as one key renewable-chemical for the development of several products, namely di(2-ethylhexyl) 2,5-furandicarboxylate (DEHF) plasticizer. This study addresses the use of DEHF under a realistic scenario of the co-existence of both DEHF and entirely fossil-based plasticizers. More precisely, original PVC blends using mixtures of non-toxic DEHF and di(2-ethylhexyl) terephthalate ester (DEHT) were designed. The detailed structural, thermal, and mechanical characterization of these materials showed that they all have a set of interesting properties that are compatible with those of commercial DEHT, namely a low glass transition (19.2–23.8 °C) and enhanced elongation at break (up to 330%). Importantly, migration tests under different daily situations, such as for example exudation from food/beverages packages and medical blood bags, reveal very low weight loss percentages. For example, in both distilled water and phosphate buffered saline (PBS) solution, weight loss does not exceed ca. 0.3% and 0.2%, respectively. Viability tests show, for the first time, that up to 500 μM of DEHF, a promising cytotoxic profile is observed, as well as for DEHT. Overall, this study demonstrates that the combination of DEHF and DEHT plasticizers result in a noticeable plasticized PVC with an increased green content with promising cytotoxic results.

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“…Obviously, infusion pumps require different set properties than those required for gravity therapy [15]. Since infusion pressure sets may be confused with gravity sets, the question is whether dosing accuracy is maintained in this case, or the gravity set is destroyed by a volumetric infusion pump [16,17].…”

Section: In Fu S Ion Set S An D Stan D Ar D Req U Ir Em En T Smentioning

confidence: 99%

“…In addition to this curve, the resulting test report includes accurate records of maximum force, stress, absolute elongation and tensile modulus. This quantity characterizes the strength of the material and its elastic deformation ability, as specified in Hook's law for elastic deformation [16,17]. For resilient polymeric materials, Hook's law is limited to a small portion of the recorded curve.…”

Section: Mechanical Elongation Testmentioning

confidence: 99%

Influence of the Use of Gravity Sets in a Pressure Volumetric Infusion Pump With an Impact on the Accuracy of Infusion Solution Flows

2020

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The subject of the work was the experimental verification of the negative influence of gravity sets in a pressure volumetric infusion pump with an impact on the accuracy of infusion solution dosing. The quality criterion for gravity sets was the accuracy of the flow versus the reference set by the volumetric infusion pump. The solution consisted of 14-hour measurements with two types of gravity sets, Intrafix® Primeline sets were used as universal sets and Standardline IS‑103 gravity sets. The insulin pump flow rate was set at 300 ml/h and 50 ml/h, and the actual flow rate of the infusion solution was recorded every hour using a graduated cylinder. Used gravity sets were also processed by mechanical tests, unused sets were subjected to these tests and the obtained data were compared with each other. Experiments carried out showed that at the set flow rate of 300 ml/h, the flow error with the universal set was -3% and at a set flow rate of 50 ml/h the error was +2.3%. Flow accuracy using gravity sets was worse, a flow error of -7.2% was detected for a flow rate of 50 ml/h and a flow error of -7.7% was measured for 300 ml/h. The volumetric pump used declares a tolerated inaccuracy of ± 3% when used with standard infusion sets. Based on the data, it can be concluded that the replacement of set types has an influence on the dosage of infusion solutions.

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Patients’ exposure to PVC plasticizers from ECMO circuits

Abstract: Our study shows that circuits made of PVC plasticized with TOTM against DEHP improves the safety of ECMO.

Cited by 17 publications

References 18 publications

New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices

New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices

Replacing Di(2-ethylhexyl) Terephthalate by Di(2-ethylhexyl) 2,5-Furandicarboxylate for PVC Plasticization: Synthesis, Materials Preparation and Characterization

Influence of the Use of Gravity Sets in a Pressure Volumetric Infusion Pump With an Impact on the Accuracy of Infusion Solution Flows

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