Patients’ appropriateness, acceptability, usability and preferences for pharmaceutical preparations: Results from a literature review on clinical evidence

Drumond, Nélio; Riet‐Nales, Diana A. van; Karapinar-Çarkıt, Fatma; Stegemann, Sven

doi:10.1016/j.ijpharm.2017.02.029

Cited by 54 publications

(45 citation statements)

References 60 publications

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“…Of these, only 35 investigated dosage form design, and 11 exclusively assessed dosage forms for the oral route. None of these studies used a DCE analysis that provides valid estimates of WTP [18].…”

Section: Discussionmentioning

confidence: 99%

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Patients’ Preferences and Willingness to Pay for Solid Forms of Oral Medications—Results of the Discrete Choice Experiment in Polish Outpatients

2020

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Purpose: Personal preferences play an important role in the patients' decision process whether to adhere to treatment, or not. The purpose of this study is to assess Polish outpatients' preferences for solid forms of oral medications across various scenarios. Methods: The convenience sample of 200 outpatients took part in this study. According to the discrete choice experiment (DCE) design, participants were provided with selection of tablets and capsules, in different shapes, sizes, colors, and copayment levels and were asked to state their preferences. DCE results were analyzed using mixed logit (MXL) models. Results: MXL models revealed patients' willingness to pay for various solid forms of medications. The most preferred combination of drug parameters were: small yellow capsule for chronic treatment, and small yellow long tablet for short-term treatment. Study participants were happy to pay extra 6.52 PLN (≈1.63 EUR) for this drug formulation per month of antihypertensive treatment, and 14.44 PLN (≈3.61 EUR) for this drug formulation per 7-days' long course of antibiotic treatment, respectively. Conclusion: Results suggest that color, shape, and size of solid form of oral medications are important predictors of patients' acceptance. It can not only be expressed in monetary value, but also may serve as an important hint for companies designing new drugs, or policymakers who are happy to improve patient adherence with better prescribing, or dispensing. However, our findings are probably country-specific, and further research is necessary to better understand the relationship between solid drug characteristics, and patient's preferences across countries.

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Section: Discussionmentioning

confidence: 99%

“…DCE survey is a systematic method grounded in both economics [15] and psychology [18]. Discrete choice experiment analysis is increasingly used in medical scientific research to quantify patient preferences for attributes of recommended medication [19].…”

Section: Discussionmentioning

confidence: 99%

Patients’ Preferences and Willingness to Pay for Solid Forms of Oral Medications—Results of the Discrete Choice Experiment in Polish Outpatients

2020

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“…To ensure treatment success, the European Medicine Agency (EMA) and the International Council for Harmonisation have highlighted in their guidelines that acceptability assessment should be investigated during the development of medicines for paediatric use. A recently published review identified only 10 clinical studies comparing the appropriateness, acceptability or preference for different dosage form designs in paediatric populations, of which three studies used a validated methodology . This methodology, focusing on medicine swallowability, fails to incorporate the multidimensional aspect of medicine acceptability.…”

Section: Introductionmentioning

confidence: 99%

“…A recently published review identified only 10 clinical studies comparing the appropriateness, acceptability or preference for different dosage form designs in paediatric populations, of which three studies used a validated methodology. [4] This methodology, focusing on medicine swallowability, fails to incorporate the multidimensional aspect of medicine acceptability. In parallel, the EMA guideline has also identified the need for an internationally harmonised method to assess acceptability.…”

Section: Introductionmentioning

confidence: 99%

Standardised evaluation of medicine acceptability in paediatric population: reliability of a model

Vallet

Ruiz

Lavarde

et al. 2017

Journal of Pharmacy and Pharmacology

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ObjectivesOur novel tool to standardise the evaluation of medicine acceptability was developed using observational data on medicines use measured in a paediatric population included for this purpose (0–14 years). Using this tool, any medicine may be positioned on a map and assigned to an acceptability profile. The present exploration aimed to verify its statistical reliability.MethodsPermutation test has been used to verify the significance of the relationships among measures highlighted by the acceptability map. Bootstrapping has been used to demonstrate the accuracy of the model (map, profiles and scores of acceptability) regardless of variations in the data. Lastly, simulations of enlarged data sets (×2; ×5; ×10) have been built to study the model's consistency.Key findingsPermutation test established the significance of the meaningful pattern identified in the data and summarised in the map. Bootstrapping attested the accuracy of the model: high RV coefficients (mean value: 0.930) verified the mapping stability, significant Adjusted Rand Indexes and Jaccard coefficients supported clustering validity (with either two or four profiles), and agreement between acceptability scores demonstrated scoring relevancy. Regarding enlarged data sets, these indicators reflected a very high consistency of the model.ConclusionsThese results highlighted the reliability of the model that will permit its use to standardise medicine acceptability assessments.

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“…Solid oral dosage forms, such as tablets and capsules, are considered superior to liquids in terms of masking unpleasant tastes, accurate dosing, production costs, stability and logistics . In the last few decades, studies have shown that infants and young children can swallow small tablets of 2–4 mm and that they may even prefer solid formulations to liquids . In clinical practice, though, solid monolithic formulations are seldom available in an appropriate dose and size to treat common paediatric diseases .…”

Section: Introductionmentioning

confidence: 99%

Register‐based study showed that the age when children were prescribed antibiotic tablets and capsules instead of liquids increased from 2004 to 2016

Bergene

Nordeng

Rø³

et al. 2018

Acta Paediatrica

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Patients’ appropriateness, acceptability, usability and preferences for pharmaceutical preparations: Results from a literature review on clinical evidence

Cited by 54 publications

References 60 publications

Patients’ Preferences and Willingness to Pay for Solid Forms of Oral Medications—Results of the Discrete Choice Experiment in Polish Outpatients

Patients’ Preferences and Willingness to Pay for Solid Forms of Oral Medications—Results of the Discrete Choice Experiment in Polish Outpatients

Standardised evaluation of medicine acceptability in paediatric population: reliability of a model

Register‐based study showed that the age when children were prescribed antibiotic tablets and capsules instead of liquids increased from 2004 to 2016

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