Patients and neurologists have different perceptions of multiple sclerosis symptoms, care and challenges

Marin, Cássia Elisa; Kfouri, Paula Prado; Callegaro, Dagoberto; Lana-Peixoto, Marco Aurélio; Neto, Antônio Pereira Gomes; Vasconcelos, Cláudia Cristina Ferreira; d'Almeida, José Artur Costa; Gonçalves, Marcus Vinícius Magno; Mendes, Maria Fernanda; Parolin, Mônica Koncke Fiuza; Nascimento, Osvaldo J. M.; Gama, Paulo Diniz da; Dias-Carneiro, Rafael Paternò Castello; Dias, Ronaldo Maciel; Damasceno, Alfredo; Martin, Gustavo San; Becker, Jéfferson

doi:10.1016/j.msard.2021.102806

Cited by 12 publications

(6 citation statements)

References 24 publications

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“…Similar to our study, invisible symptoms were significant predictors of health distress among PwMS in a US study, although private and work aspects of life were not analyzed separately [38]. Invisible symptoms were also highlighted by PwMS in a study where patients and physicians expressed divergent views on which symptoms have the most significant consequences for patients [39]. The role of cognitive impairment in limiting participation of PwMS in activities of daily living was shown by a Swedish study [40].…”

Section: Discussionmentioning

confidence: 99%

Self‐reported restrictions in different life domains and associated factors among people with multiple sclerosis in Sweden

Teni

Machado

Murley

et al. 2023

Euro J of Neurology

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Background and purpose The heterogeneous symptoms of multiple sclerosis (MS) can considerably impact the lives of people with MS (PwMS). The aim of this study was to describe the extent of restrictions in different life domains that PwMS experience in relation to their symptoms and level of disability. Methods A cross‐sectional survey was conducted among working‐age PwMS in Sweden. The 4052 participants who answered the questions on restrictions in work and private life domains (family, leisure activities, and contact with friends/acquaintances) were included. Predictors of restrictions in the four domains were determined through multinomial logistic regression. Results Approximately one‐third of the PwMS reported no restrictions in the domains of work (35.7%), family (38.7%), leisure activities (31.1%) or contact with friends/acquaintances (40.3%), the remaining participants reported moderate to severe restrictions. Tiredness/fatigue was the most commonly reported most‐limiting symptom (49.5%). PwMS with Expanded Disability Status Scale (EDSS) scores of zero reported restrictions in life domains ranging from 39.6% (friends/acquaintances) to 45.7% (leisure activities). Age, sex, education, type of living area, MS type, type of most‐limiting symptom, and EDSS score predicted restrictions in work and private life domains. Conclusions Most PwMS reported similar levels of restrictions in both their work and private lives. Restrictions in these life domains were also reported by PwMS with low disability levels (EDSS = 0) and were often associated with invisible symptoms such as fatigue. Even in a contemporary MS cohort, close to 90% of PwMS report limitations due to MS.

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Section: Discussionmentioning

confidence: 99%

Self‐reported restrictions in different life domains and associated factors among people with multiple sclerosis in Sweden

Teni

Machado

Murley

et al. 2023

Euro J of Neurology

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“…Cognitive dysfunction has been recognized as a central problem in patients with MS 2,5,6,12 By affecting daily living activities, work capacity, and social relationships, it h.as a significant effect on the patients' quality of life 9,12,14 . Its early recognition and management may have a relevant meaning for patients with MS 9,37 .…”

Section: Discussionmentioning

confidence: 99%

Cognitive assessment of Brazilian patients with multiple sclerosis: weighing the impact of disability and depressive symptoms

Andrade

Cerqueira

Colodetti

et al. 2022

Dement. neuropsychol.

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Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Cognition is not routinely assessed in patients with MS though they frequently have cognitive complaints or dysfunction. Objective: The aim of this study was to compare the cognitive status of patients with MS with age, sex, and schooling matched controls and to evaluate the potential influence of clinical parameters on cognition. Methods: A total of 35 patients with MS (mean±SD age 37.9 years±11.44, M/F: 12/23) and 33 healthy controls (mean±SD age 38.8 years±12.6, M/F: 12/21) were enrolled in this study. All subjects underwent a structured clinical assessment and the cognitive tools are as follows: Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Rey Auditory Verbal Learning Test (RAVLT), Digit Span, and Verbal Fluency Tests (letters F, A, and S and animal category). Psychopathology was assessed with the Mini International Neuropsychiatric Interview and the Beck Depression Inventory (BDI). The Expanded Disability Status Scale (EDSS) was used for patients. Results: Patients performed worse than controls in almost all tests, with approximately 70% of patients presenting cognitive impairment. The most affected cognitive domain was episodic memory (45.7%), followed by verbal fluency (42.8%) and information processing speed (22.8%). SDMT was inversely correlated with disease severity, as assessed by the EDSS. Depression did not influence cognitive performance in this cohort. Conclusions: Cognitive dysfunction is common among patients with MS. While motor impairment was associated with information processing speed, depression did not influence cognitive performance.

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“…Multiple sclerosis [17][18][19] It is considered as the most prevalent chronic inflammatory disease of the central nervous system associated with inflammatory demyelination and astroglial activation, where the neuronal and axonal injury as the leading factors of disability. Young individuals (20 to 40 years old), generally, are more affected, and late-onset multiple sclerosis characterized when symptoms initiating after 50 years.…”

Section: Neurological Disorder Definition/etiology/prevalence Signals and Symptomsmentioning

confidence: 99%

Introductory Chapter: Neurological Disorders - Therapy Approaches

Sá-Caputo¹,

Bernardo-Filho²,

Seixas³

et al. 2021

Therapy Approaches in Neurological Disorders

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Patients and neurologists have different perceptions of multiple sclerosis symptoms, care and challenges

Cited by 12 publications

References 24 publications

Self‐reported restrictions in different life domains and associated factors among people with multiple sclerosis in Sweden

Self‐reported restrictions in different life domains and associated factors among people with multiple sclerosis in Sweden

Cognitive assessment of Brazilian patients with multiple sclerosis: weighing the impact of disability and depressive symptoms

Introductory Chapter: Neurological Disorders - Therapy Approaches

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