Patient specific computer automated dosimetry calculations during therapy with 111In Octreotide

Vamvakas, Ioannis; Lаgopati, Nefeli; Andreou, Maria; Sotiropoulos, Marios; Gatzis, Athanasios; Limouris, Georgios S.; Antypas, Christos; Lyra, Maria

doi:10.1016/j.ejradi.2010.08.001

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Thus, photocatalysts, such as TiO 2 are promising candidates to provide protection even against SARS-CoV-2, offering bactericidal and virucidal activity. Due to the biocompatibility and the great spectrum of anticancer and antimicrobial properties, TiO 2 is utilized in various biomedical applications, such as in drug delivery systems (DDS), in molecular imaging as well as in alternative therapeutic approaches, in parallel with conventional methods or in replacement of them (3,4).…”

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confidence: 99%

Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Lаgopati

Kotsinas

Veroutis

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO 2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO 2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO 2 NPs) with anticancer potential. Materials and Methods: Ag/TiO 2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and Conclusion: We show that photo-activated Ag/TiO 2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.Nanomedicine is an emerging inter-disciplinary scientific field that exploits the unique properties of innovative 425 This article is freely accessible online.

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confidence: 99%

Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Lаgopati

Kotsinas

Veroutis

et al. 2021

Cancer Genomics Proteomics

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“…The results showed that the tumor absorbed dose ranged from 2.5mGy/MBq to 18.4mGy/MBq depending on the lesion size [13]. The average absorbed dose per session to a tumor for a spherical mass of 10 gr was estimated to be 10.8 mGy/MBq, depending on the histotype of the tumor.…”

Section: Resultsmentioning

confidence: 99%

“…This is proved to be the best method to give better uptake of the radiopharmaceutical by the tumor. Patient specific dose estimation for the tumor and healthy tissue is very important for radiopharmaceutical therapeutic applications as this is the most accurate way to assign an administered dose to the best therapeutic result [13][14][15]. It is also assistance to the physician in order to avoid side effects of the therapy and compare the treatment results to other related therapies as external radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Auger electrons with particle ranges (.02-10) μm and Internal Conversion electrons with ranges (200-550) μm that In-111 emits during its transformation procedure are extremely short. In large arteries blood can be approximated as homogeneous Newtonian fluid because the vessel size is much greater than the size of particles; particles' interactions have a negligible effect on the flow [5,6,8,13].…”

Section: B In-111 Uptake and Biokinetic Propertiesmentioning

confidence: 99%

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https://researchopenworld.com/blood-flow-and-arterial-infusion-by-implanted-port-in-in-111-octreotide-therapy/#

2019

Interv Med Clin Imaging

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In-111-Octreotide infusion, via intrahepatic catheterization is well established technique in our Institution in hepatocellular carcinoma and neuroendocrine tumors treatment. In order to facilitate repetitive infusions of our patients, a method of implanted ports use, gave a simpler therapeutic way but also improved therapy results. Our aim is to show that radiopharmaceutical fluid flow through implanted port is rich; the absorbed dose in the tumor increased for best therapy results. Surgically implanted ports have been used in repetitive intra-arterial In-111 radiolabeled Octreotide infusions for 22 patients with hepatocellular carcinoma and similarly 18 patients with neuroendocrine tumors in a continuous base. A percutaneous implantation procedure facilitates safe and less invasive radiopharmaceutical infusions for the treatment. We have focused on the interventional techniques for percutaneous implantation of a vascular access device, consisting of an implantable port, to perform In-111 Octreotide infusions. Hepatic arterial infusion radiotherapy employs a hepatic artery catheter as a conduit to achieve a high concentration of radiolabeled agent to liver tumors. It is performed using less-invasive percutaneous image guided procedures. Various techniques were used to ensure high concentration of radiopharmaceutical in liver tumors, as there are many anatomical hepatic arterial variations and complicated blood flow patterns. These techniques are composed of arterial redistribution by embolization, percutaneous catheter placement, evaluation and management of flow patterns that reflect In-111 Octreotide distribution. Using fluid flow theory, we describe blood flow alterations that could be performed to obtain selective radiopharmaceutical distribution to the target area and avoid side effects caused by the accumulation of the radiolabeled agent into non tumor areas. By steady, laminar and disturbed flow equations, the rich distribution of our agent in the scintigraphy imaging of the tumor, by the implanted ports technique, can be explained. The factors affecting hepatic arterial flow in tumor feeding artery were analyzed. The patency rate of the hepatic artery was significantly higher in patients with catheter placement using fixed port method than those undergo fully interventional catheterization. A ratio of 5: 1 to 3: 1 flow increase was calculated through poiseuille flow and Reynolds number for circular pipe. We consider that in continuous therapy, it is important to use the simplest fixed port method for percutaneous catheter placement instead of interventional catheterization, in order to increase absorbed dose into tumor for best response of radionuclide therapy.

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