Patient's perception of exacerbations of COPD—the PERCEIVE study

Miravitlles, Marc; Anzueto, Antonio; Legnani, D.; Forstmeier, Leonhard; Fargel, M.

doi:10.1016/j.rmed.2006.07.010

Cited by 125 publications

(90 citation statements)

References 41 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The characteristic symptoms of COPD include breathlessness, cough and increased sputum production and, based on cohort studies, there is now extensive evidence that COPD symptoms have a considerable impact on patients' daily activities, health status and quality of life [4][5][6][7][8]. Furthermore, while COPD is diagnosed clinically based on persistent airflow limitation, it is the impact of symptoms on patients' daily lives that generally drives them to seek a diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study

Miravitlles

Worth

Cataluña

et al. 2014

Respiratory Research

Self Cite

136

View full text Add to dashboard Cite

Background: Few studies have investigated the 24-hour symptom profile in patients with COPD or how symptoms during the 24-hour day are inter-related. This observational study assessed the prevalence, severity and relationship between night-time, early morning and daytime COPD symptoms and explored the relationship between 24-hour symptoms and other patient-reported outcomes. Methods: The study enrolled patients with stable COPD in clinical practice. Baseline night-time, early morning and daytime symptoms (symptom questionnaire), severity of airflow obstruction (FEV 1 ), dyspnoea (modified Medical Research Council Dyspnoea Scale), health status (COPD Assessment Test), anxiety and depression levels (Hospital Anxiety and Depression Scale), sleep quality (COPD and Asthma Sleep Impact Scale) and physical activity level (sedentary, moderately active or active) were recorded. Results: The full analysis set included 727 patients: 65.8% male, mean ± standard deviation age 67.2 ± 8.8 years, % predicted FEV 1 52.8 ± 20.5%. In each part of the 24-hour day, >60% of patients reported experiencing ≥1 symptom in the week before baseline. Symptoms were more common in the early morning and daytime versus night-time (81.4%, 82.7% and 63.0%, respectively). Symptom severity was comparable for each period assessed. Overall, in the week before baseline, 56.7% of patients had symptoms throughout the whole 24-hour day (3 parts of the day); 79.9% had symptoms in ≥2 parts of the 24-hour day. Symptoms during each part of the day were inter-related, irrespective of disease severity (all p < 0.001). Early morning and daytime symptoms were associated with the severity of airflow obstruction (p < 0.05 for both). Nighttime, early morning and daytime symptoms were all associated with worse dyspnoea, health status and sleep quality, and higher anxiety and depression levels (all p < 0.001 versus patients without symptoms in each corresponding period). In each part of the 24-hour day, there was also an association between symptoms and a patient's physical activity level (p < 0.05 for each period).

show abstract

Section: Introductionmentioning

confidence: 99%

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study

Miravitlles

Worth

Cataluña

et al. 2014

Respiratory Research

Self Cite

136

View full text Add to dashboard Cite

show abstract

“…On the other hand, a weak breath is the most common symptom reported by long-term COPD patients 9 , and it significantly reduces the quality of life 10,11 . Therefore, it is necessary to estimate patients' airflow and thus modified Medical Research Council (mMRC) dyspnea scale is used 12 .…”

Section: Introductionmentioning

confidence: 99%

Correlation of C-Reactive Protein and Copd Severity

Milacic

2016

ACC

View full text Add to dashboard Cite

SUMMARY -Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary disease characterized by systemic inflammation. The aim of this study was to correlate the parameters of systemic inflammation, C-reactive protein (CPR) and total leukocyte count, with clinical indicators of the disease. Our study included 157 COPD patients, both outpatients and those hospitalized at the Knez Selo Department of Pulmonology of the Niš Clinical Centre during a six-month period, while in the phase of disease exacerbation. The symptoms of COPD in each patient were estimated by the COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scale. The parameters of pulmonary function (FEV1 and FVC), acid-base status, body mass index, history of exacerbation and comorbidities were also evaluated. The level of CRP, but not leukocytes, showed significant correlation with the severity of clinical presentation according to GOLD classification. The higher the CRP concentration, the higher was the disease severity determined according to GOLD classification (p<0.001). There was no statistically significant difference in CRP level and leukocyte count according to comorbidities (p=0.29). The level of CRP was higher in patients with a high CAT score and mMRC scale (p<0.001). The same trend was observed for leukocyte count when compared with CAT results, but not when correlated to mMRC scale. The level of CRP during COPD exacerbation can be an independent predictor of the disease severity and paraclinical findings.

show abstract

“…Patients with severe COPD and frequent exacerbations present an excessive decline in lung function over time [13]. Patients are frightened of exacerbations and have important limitations in their daily life activities because of these episodes [14,15]. The impact of exacerbations in the health status of patients with COPD was first observed by SEEMUNGAL et al [5] in a cohort of severe patients over 1 yr of follow-up.…”

Section: Definition and Frequency Of Exacerbationsmentioning

confidence: 99%

“…Based on this evidence and on the expectations of the patients, for whom the prevention of exacerbations is an important unmet need of COPD treatment [14], the prevention of episodes should be one of the main goals of COPD treatment. Table 1 summarises most of the pharmacological interventions available for the prevention of exacerbations.…”

Section: Definition and Frequency Of Exacerbationsmentioning

confidence: 99%

Prevention of exacerbations of COPD with pharmacotherapy

Miravitlles¹

2010

Eur Respir Rev

View full text Add to dashboard Cite

Exacerbations are a frequent event in the evolution of chronic obstructive pulmonary disease (COPD) patients. Individuals with COPD have a mean of 1-3 episodes per year, some of which lead to hospital admission and may even be a cause of death. The importance of COPD exacerbations has become increasingly apparent due to the impact these episodes have on the natural history of disease. It is now known that frequent exacerbations can adversely affect health-related quality of life and short-and long-term pulmonary function. Optimising treatment for stable COPD will help to reduce exacerbations.Long-acting bronchodilators, alone or combined with inhaled corticosteroids, have demonstrated efficacy in reducing the rate of exacerbations in patients with COPD. Other innovative approaches are being investigated, such as the long-term use of macrolides or the use of antibiotics in an effort to suppress bronchial colonisation and consequent exacerbations. Other drugs, such as mucolytics and immunomodulators, have recently provided positive results.Non-pharmacological interventions such as rehabilitation, self-management plans and the maintenance of high levels of physical activity in daily life are also useful strategies to prevent exacerbations in patients with COPD and should be implemented in regular clinical practice.

show abstract

Patient's perception of exacerbations of COPD—the PERCEIVE study

Cited by 125 publications

References 41 publications

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study

Correlation of C-Reactive Protein and Copd Severity

Prevention of exacerbations of COPD with pharmacotherapy

Contact Info

Product

Resources

About