Patient reported quality of life after helical IMRT based concurrent chemoradiation of locally advanced anal cancer

Joseph, Kurian; Vos, Larissa J.; Warkentin, Heather; Paulson, Kim; Polkosnik, Lee-Anne; Usmani, Nawaid; Tankel, Keith; Severin, Diane; Nijjar, Tirath; Schiller, Dan; Wong, Clarence; Ghosh, Sunita; Mulder, Karen; Field, Colin

doi:10.1016/j.radonc.2016.06.020

Cited by 33 publications

(31 citation statements)

References 34 publications

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“…The accuracy and accessibility of the information given to patients is important and therefore availability of an anal cancer HRQoL questionnaire is crucial to providing high quality data to inform decision-making. Even with more advanced, tissue sparing radiotherapy techniques such as IMRT, pelvic chemoradiation can significantly adversely affect skin toxicities, bowel, urinary and sexual dysfunction reported [33][34][35][36][37][38]. Stoma formation may also lead to permanent alteration in body image, potentially affecting the perception of themselves and their relationship with others [39].…”

Section: Discussionmentioning

confidence: 99%

Phase I–III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer

Sodergren

Johnson

Gilbert

et al. 2018

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 99%

Phase I–III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer

Sodergren

Johnson

Gilbert

et al. 2018

Radiotherapy and Oncology

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“…Assessment of quality of life after radiotherapy was performed using were QLQ-C30 [119,120], QLQ-CR38 [121,122], QLQ-CR29 [89,123], and GIQLI [124].…”

Section: Long-term Qol Of Anal Cancer Survivors After Radiotherapymentioning

confidence: 99%

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

et al. 2018

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Introduction: There is a paucity of data on incidence and mechanisms of long-term gastrointestinal consequences after chemoradiotherapy for anal cancer. Most of the adverse effects reported were based on traditional external beam radiotherapy whilst only short-term follow-ups have been available for intensity-modulated radiotherapy, and there is lack of knowledge about consequences of doseescalation radiotherapy. Method: A systematic literature review. Results: Two thousand nine hundred and eighty-five titles (excluding duplicates) were identified through the search; 130 articles were included in this review. The overall incidence of late gastrointestinal toxicity was reported to be 7-64.5%, with Grade 3 and above (classified as severe) up to 33.3%. The most commonly reported late toxicities were fecal incontinence (up to 44%), diarrhea (up to 26.7%), and ulceration (up to 22.6%). Diarrhea, fecal incontinence and buttock pain were associated with lower scores in radiotherapy specific quality of life scales (QLQ-CR29, QLQ-C30, and QLQ-CR38) compared to healthy controls. Intensity-modulated radiation therapy appears to reduce late toxicity. Conclusion: Late gastrointestinal toxicities are common with severe toxicity seen in one-third of the patients. These symptoms significantly impact on patients' quality of life. Prospective studies with control groups are needed to elucidate long-term toxicity.

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“…A review article by Sodergren et al summarised the few published studies up to 2014 and found that the most common complications after treatment for anal cancer were skin conditions, faecal incontinence and sexual problems, but psychological side effects such as depression and fatigue also occurred [8]. However, since then, some longitudinal studies with baseline data have been published [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Quality of life in patients treated for anal carcinoma—a systematic literature review

Sterner

Derwinger

Staff

et al. 2019

Int J Colorectal Dis

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Purpose Anal cancer is a mainly treated with chemoradiotherapy. A small number of patients undergo salvage surgery. There are few published studies investigating quality of life and functional outcome after treatment for anal cancer. The aim of this review was to explore the literature and identify areas for further research. Methods A search was conducted in Medline using MESH terms related to anal cancer and quality of life. Two investigators selected and reviewed articles based on titles and abstracts. Three investigators read and reviewed the included articles and collected relevant data. The included articles were evaluated using the minimum standard checklist, and key findings were summarised in a chart. Results Some 15 articles, and a total of 802 patients, were deemed eligible. The results differed slightly among the studies. The incidence of symptoms such as fatigue, nausea, insomnia and appetite loss was higher than among healthy volunteers. Bowel function, urinary function and sexual function were negatively affected. Some studies found that, compared with the normal population, anal cancer survivors scored clinically significant worse in the functional scales in QLQ-C30. Conclusion In conclusion, it is apparent that several functional problems affect the quality of life of patients with anal cancer. There are few studies which have investigated quality of life after treatment for anal cancer. Interventions to address issues related to anal cancer treatment may improve long-term quality of life in this patient group. Trial registration CRD42017059787

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Patient reported quality of life after helical IMRT based concurrent chemoradiation of locally advanced anal cancer

Cited by 33 publications

References 34 publications

Phase I–III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer

Phase I–III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

Quality of life in patients treated for anal carcinoma—a systematic literature review

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