Patient-reported outcomes measures and patient preferences for minimally invasive glaucoma surgical devices

Li, Tianjing; Lê, Jimmy T.; Cui, Qi N.; Eydelman, Malvina B.; Spaeth, George L.; Tarver, Michelle E.; Singh, Kuldev

doi:10.1038/s41433-019-0676-8

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…Interestingly, our study has shown that IOP is considered as the most important outcome by some patients. This is in keeping with previous work which ranked patient’s preferences [ 27 , 28 ]. However, our work suggests that patients may also have different expectations to each other.…”

Section: Discussionsupporting

confidence: 88%

Treatment expectations in glaucoma: what matters most to patients?

Safitri

Konstantakopoulou

et al. 2023

Eye

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Background/Objectives Recent clinical trials in glaucoma have used patient-reported outcome measures (PROMs) of health-related quality of life to evaluate interventions. However, existing PROMs may not be sufficiently sensitive to capture changes in health status. This study aims to determine what really matters to patients by directly exploring their treatment expectations and preferences. Subjects/Methods We conducted a qualitative study using one-to-one semi-structured interviews to elicit patients’ preferences. Participants were recruited from two NHS clinics serving urban, suburban and rural populations in the UK. To be relevant across glaucoma patients under NHS care, participants were sampled to include a full range of demographic profiles, disease severities and treatment histories. Interview transcripts were evaluated using thematic analysis until no new themes emerged (saturation). Saturation was established when 25 participants with ocular hypertension, mild, moderate and advanced glaucoma had been interviewed. Results Themes identified were: Patients’ experiences of living with glaucoma, patients’ experiences of having glaucoma treatment, most important outcomes to patients, and COVID-related concerns. Participants specifically expressed their most important concerns, which were (i) disease-related outcomes (intraocular pressure control, maintaining vision, and being independent); and (ii) treatment-related outcomes (treatment that does not change, drop-freedom, and one-time treatment). Both disease-related and treatment-related experiences were covered prominently in interviews with patients across the spectrum of glaucoma severity. Conclusions Outcomes related both to the disease and its treatment are important to patients with different severities of glaucoma. To accurately evaluate quality of life in glaucoma, PROMs may need to assess both disease-related and treatment-related outcomes.

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Section: Discussionsupporting

confidence: 88%

Treatment expectations in glaucoma: what matters most to patients?

Safitri

Konstantakopoulou

et al. 2023

Eye

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“…It is noteworthy, however, that a previous study exploring preference elicitation in glaucoma indicated reduced number of IOP-lowering drops was regarded with relatively little importance compared with other aspects of visual functioning, such as maintaining indoor and outdoor mobility and driving capacity. 41 These findings provide further justification for incorporation of outcome measures that capture a range of glaucoma-related challenges, including functioning, well-being, visual perception and treatment burden.…”

Section: Discussionmentioning

confidence: 86%

Impact of minimally invasive glaucoma surgery on the ocular surface and quality of life in patients with glaucoma

et al. 2023

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Background: Minimally invasive glaucoma procedures are emerging as clinically effective and safe glaucoma management approaches; however, evidence regarding quality-of-life outcomes is limited. Objectives: To explore the impact of minimally invasive glaucoma surgery (MIGS) combined with phacoemulsification on patient-reported outcomes and clinical parameters related to ocular surface disease in people with glaucoma. Design: Retrospective observational study. Methods: Fifty-seven consecutive patients were examined prior to undergoing iStent combined with phacoemulsification with or without adjunctive endocyclophotocoagulation and at 4-month follow-up. Results: At follow-up, on average patients returned statistically significantly improved scores on glaucoma-specific (GQL-15, p < 0.001; GSS, p < 0.001), general health (EQ-5D, p = 0.02) and ocular surface PROMs (OSDI, p = 0.001). Patients were using fewer eye drops on average after MIGS compared with before surgery (1.1 ± 0.9 versus 1.8 ± 0.8; p < 0.001). Undergoing MIGS was associated with improved tear film break-up time ( p < 0.001) and reduced corneal fluorescein staining ( p < 0.001). Conclusion: This retrospective audit shows quality of life and clinical parameters related to the ocular surface are improved following MIGS combined with phacoemulsification in patients previously treated with anti-glaucoma therapy.

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“…Ten articles presenting 11 studies met the inclusion criteria and remained for synthesis after the selection process (Fig. 1) [22][23][24][25][26][27][28][29][30][31][32]. One of the articles presents two separate studies [29].…”

Section: Resultsmentioning

confidence: 99%

Eliciting preferences in glaucoma management—a systematic review of stated-preference studies

Scheres

Hiligsmann

Gorcom

et al. 2023

Eye

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Background In most cases, glaucoma patients require long-term medical and/or surgical treatment. Preference studies investigate how different aspects of glaucoma management, such as health or process outcomes, are valued and herewith help stakeholders make care more responsive to patients’ needs. As, to our knowledge, no overview of these studies is currently available, this study aims to systematically review and critically appraise these studies. Methods A systematic literature review was conducted using keywords for stated-preference studies and glaucoma up to October 2021. Studies were included if they were original research and used a stated-preference methodology to investigate preferences in patients or healthcare professionals for different aspects of glaucoma management. Data were extracted and summarized. Furthermore, a quality appraisal of the included studies was performed using two validated checklists. Results The search yielded 1214 articles after removal of duplicates. Of those, 11 studies fulfilled the inclusion criteria. Studies aimed to elicit preferences for glaucoma treatment (27%), glaucoma related health state valuation (36%), and services (36%) from the patient (91%) or ophthalmologists’ perspective (9%). Altogether studies included 69 attributes. The majority of attributes were outcome related (62%), followed by process (32%) and cost attributes (6%). Outcome attributes (e.g., effectiveness) were most often of highest importance to the population. Conclusions This systematic review provides an up-to-date and critical review of stated-preference studies in the field of glaucoma, suggesting that patients have preferences and are willing to trade-off between characteristics, and revealed that outcome attributes are the most influential characteristics of glaucoma management.

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Patient-reported outcomes measures and patient preferences for minimally invasive glaucoma surgical devices

Cited by 10 publications

References 11 publications

Treatment expectations in glaucoma: what matters most to patients?

Treatment expectations in glaucoma: what matters most to patients?

Impact of minimally invasive glaucoma surgery on the ocular surface and quality of life in patients with glaucoma

Eliciting preferences in glaucoma management—a systematic review of stated-preference studies

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