Patient-reported outcomes and gut dysmotility in functional gastrointestinal disorders

Cogliandro, Rosanna; Antonucci, Alexandra; Giorgio, Roberto De; Barbara, Giovanni; Cremon, Cesare; Cogliandro, L.; Frisoni, Chiara; Pezzilli, Raffaele; Morselli-Labate, Antonio Maria; Corinaldesi, Roberto; Stanghellini, Vincenzo

doi:10.1111/j.1365-2982.2011.01783.x

Cited by 50 publications

(40 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, FBDs are responsible for prolonged absenteeism from work as well as for suboptimal performance in the workplace with relevant social costs. 5,6 Amongst FBDs, IBS is certainly the most common clinical entity affecting up to 20% of the general population. 7 Classically, an IBS diagnosis revolves around abdominal pain/discomfort in conjunction with altered bowel habits.…”

Section: Introductionmentioning

confidence: 99%

Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

Volta

Sánchez

Boschetti

et al. 2016

J Neurogastroenterol Motil

View full text Add to dashboard Cite

A tight link exists between dietary factors and irritable bowel syndrome (IBS), one of the most common functional syndromes, characterized by abdominal pain/discomfort, bloating and alternating bowel habits. Amongst the variety of foods potentially evoking "food sensitivity", gluten and other wheat proteins including amylase trypsin inhibitors represent the culprits that recently have drawn the attention of the scientific community. Therefore, a newly emerging condition termed non-celiac gluten sensitivity (NCGS) or nonceliac wheat sensitivity (NCWS) is now well established in the clinical practice. Notably, patients with NCGS/NCWS have symptoms that mimic those present in IBS. The mechanisms by which gluten or other wheat proteins trigger symptoms are poorly understood and the lack of specific biomarkers hampers diagnosis of this condition. The present review aimed at providing an update to physicians and scientists regarding the following main topics: the experimental and clinical evidence on the role of gluten/wheat in IBS; how to diagnose patients with functional symptoms attributable to gluten/wheat sensitivity; the importance of double-blind placebo controlled cross-over trials as confirmatory assays of gluten/wheat sensitivity; and finally, dietary measures for gluten/wheat sensitive patients. The analysis of current evidence proposes that gluten/wheat sensitivity can indeed represent a subset of the broad spectrum of patients with a clinical presentation of IBS. (J Neurogastroenterol Motil 2016;22:547-557)

show abstract

Section: Introductionmentioning

confidence: 99%

Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

Volta

Sánchez

Boschetti

et al. 2016

J Neurogastroenterol Motil

View full text Add to dashboard Cite

show abstract

“…Some have found specific abnormal motility patterns correlating to the different IBS subtypes [13,14], while others have found virtually no signs of dysmotility [15,16]. …”

Section: Introductionmentioning

confidence: 99%

A randomised, controlled study of small intestinal motility in patients treated with sacral nerve stimulation for irritable bowel syndrome

et al. 2014

View full text Add to dashboard Cite

BackgroundIrritable bowel syndrome (IBS) is among the most common gastrointestinal disorders worldwide. In selected patients with severe diarrhoea-predominant or mixed IBS subtypes sacral nerve stimulation (SNS) alleviates IBS-specific symptoms and improves quality of life. The mode of action, however, remains unknown. The present study aimed to evaluate the effect of SNS on small intestinal motility in IBS patients.MethodsTwenty patients treated with SNS for severe diarrhoea-predominant or mixed IBS were included in a randomised, controlled, crossover study. The neurostimulator was turned ON or OFF for the first one month and then to the opposite setting for the next month. Gastrointestinal transit patterns were investigated with the Motility Tracking System-1 (MTS-1) at the end of each the ON and OFF period. Primary endpoint was change in the velocity of the magnetic pill within the small intestine. Statistical testing was performed with Wilcoxon’s rank sum test and Fisher’s exact test.ResultsThe median velocity of the magnetic pill through the small intestine in the fasting state was not significantly different between periods with and without SNS (Group ON-OFF: median change 0 m/h (range -1.07, 0.63), Group OFF-ON: median change 0.27 m/h (range -0.59, 1.12)) (p = 0.25). Neither, was the median velocity of the magnetic pill through the small intestine in the postprandial state significantly different between periods with and without SNS (Group ON-OFF: median change -0.13 m/h (range -0.46, 0.23), Group OFF-ON: median change 0.015 m/h (range -0.48, 0.59)) (p = 0.14).ConclusionEven though SNS may reduce symptoms of diarrhoea-predominant and mixed IBS, it has no detectable effect on small intestinal transit patterns.Trial registrationClinical.trials.gov, (NCT00919672).

show abstract

“…During the last decade, earlier diagnosis had led to improved management and survival of children with CIPO, which was also achieved through the nutritional strategies that are finalized to achieve normal growth and development [104]. This could be supported by evidence that improvement of nutritional status also determined the improvement of intestinal motility [105]. PN is often required for months or years and can be associated with complications responsible for most of the morbidity and mortality of CIPO [106].…”

Section: Intestinal Failurementioning

confidence: 99%

“…PN is often required for months or years and can be associated with complications responsible for most of the morbidity and mortality of CIPO [106]. EN can be attempted to avoid using PN, and generally gastrostomy is performed in both pediatric and adult patients for gastric decompression and/or feedings [104][105][106][107]. In selected children, JF can be an alternative option to PN.…”

Section: Intestinal Failurementioning

confidence: 99%

Clinical management of post-pyloric enteral feeding in children

Capriati

Cardile

Chiusolo

et al. 2015

Expert Review of Gastroenterology & Hepatology

View full text Add to dashboard Cite

Post-pyloric feeding (PF) allows the administration of enteral nutrition beyond the pylorus, either into the duodenum or, ideally, into the jejunum. The main indications of PF are: upper gastrointestinal tract obstructions, pancreatic rest (e.g., acute pancreatitis), gastric dysmotility (e.g., critically ill patients and chronic intestinal pseudo-obstruction) or severe gastroesophageal reflux with risk of aspiration (e.g., neurological disability). Physiological and clinical evidence derives from adults, but can also be pertinent to children. This review will discuss the practical management and potential clinical applications of PF in pediatric patients. Some key studies pertaining to the physiological changes during PF will also be considered because they support the strategy of PF management.

show abstract

Patient-reported outcomes and gut dysmotility in functional gastrointestinal disorders

Cited by 50 publications

References 47 publications

Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

A randomised, controlled study of small intestinal motility in patients treated with sacral nerve stimulation for irritable bowel syndrome

Clinical management of post-pyloric enteral feeding in children

Contact Info

Product

Resources

About