Patient-Reported Outcomes After Use of a Bioabsorbable Collagen Implant to Treat Partial and Full-Thickness Rotator Cuff Tears

McIntyre, Louis F.; Bishai, Shariff K.; Brown, Paul B.; Bushnell, Brandon D.; Trenhaile, Scott W.

doi:10.1016/j.arthro.2019.02.019

Cited by 40 publications

(53 citation statements)

References 38 publications

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“…Surgery proceeded as planned and the SAD, DCE, open subpectoral biceps tenodesis were completed without complication. The decision was made to repair the rotator cuff with a bio-inductive collagen implant [3][4][5][6] after assessing the appearance of the RCT after débridement (Figure 2b-c). The tear was not significant enough to warrant complete takedown with repair as it was less than 50% of the overall tendon width and the bursal surface was completely intact (Figure 2c).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…The technique for application of the bio-inductive collagen implant has been previously described. [2][3][4][5][6][7][8] The patient's initial postoperative period proceeded without issue. She followed our standard physical therapy protocol for subpectoral biceps tenodesis for the first six weeks to protect that repair and then followed with the protocol for the rotator cuff repair with bio-inductive implant according to Schlegel et al 6 By her 3-month visit, she stated her shoulder was feeling "better and better, but still (subjectively) weak".…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

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Deltoid fascia disruption from the use of a bioinductive collagen scaffold and polyether ether ketone (PEEK) bone staples: a case report

Belk¹,

Thon²,

Bravman³

2021

JSES Reviews, Reports, and Techniques

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Deltoid fascia disruption from the use of a bioinductive collagen scaffold and polyether ether ketone (PEEK) bone staples: a case report

Belk¹,

Thon²,

Bravman³

2021

JSES Reviews, Reports, and Techniques

View full text Add to dashboard Cite

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“…As these partial tears do not typically result in significant impairment of the arm, conservative treatment is generally implemented in lieu of surgical repair (3). However, growing clinical and basic science evidence suggests that these partial tears result in a deleterious degenerative cascade of the rotator cuff tendon/muscle group, leading to fatty infiltration, loss of muscle strength, and most importantly, increased probability of full thickness tears at a later point in life (4,5). Additionally, this chronic degeneration of the tendon(s) (a.k.a., tendinopathy) has a negative impact on the clinical outcome of repair surgeries on torn tendons, with re-tear rates of arthroscopic repairs as high as 94% depending on exacerbating risk factors (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Enthesis trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model

Johnson¹,

Stade²,

Regan³

et al. 2021

Ann Transl Med

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Background: Untreated rotator cuff tears lead to irreversible tendon degeneration, resulting in unacceptable repair prognosis. The inability of current animal models of degenerated rotator cuff tendons to more fully emulate the manifestation and degree of pathology seen in humans with a previously torn rotator cuff tendon (s) significantly impairs the development of novel therapeutics. Therefore, the objective of this study was to develop a large-animal translational model of enthesis damage to the rotator cuff tendons to mimic the chronic degenerative changes that occur in patients that demonstrate clinical manifestations of tendinopathy.Methods: A partial enthesis tear model (i.e., sharp transection) in adult sheep was created by cutting the tendon fibers perpendicularly through the enthesis midpoint, while leaving the other portion of the tendon in-tact. To assess tendon integrity, non-destructive biomechanical tests were performed, followed by histopathological, histomorphological, and gene expression analysis. Samples of degenerated human rotator cuff tendons obtained from patients undergoing reverse total shoulder arthroplasty to use for comparative pathological analysis.Results: In the sheep model, transected tendons at all timepoints had significantly decreased mechanical properties. Histopathologic evaluation and Bonar scoring revealed that the tendons in sheep underwent degenerative changes similar in magnitude and manifestation as the degenerated human tendon samples. Furthermore, similar levels of collagen disorganization were noted between the 6 and 12-week ovine samples and the degenerated human samples. Conclusions: These findings indicate that the new sheep model of rotator cuff injury reliably recapitulates the structural and cellular changes that occur clinically in humans with chronic rotator cuff tendon injuries and suggest that this new model is well suited to evaluation of new therapeutic interventions.

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“…Regeneten (Smith & Nephew, Inc., Andover, MA) is a bioinductive implant composed of type 1 collagen derived from bovine Achilles tendon, which acts as a highly porous scaffold allowing the attachment of regenerative cells and transport of nutrients and waste. While initial results of Regeneten augmentation of rotator cuff repairs have been promising [11], its utility outside of the shoulder is not well explored. limited to a single case report involving bioaugmentation of surgically managed chronic patellar tendinopathy and technique descriptions without follow-up for hip abductor repairs [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Bioinductive Collagen Implant Augmentation for the Repair of Chronic Lower Extremity Tendinopathies: A Report of Two Cases

Looney¹,

Fortier²,

Leider³

et al. 2021

Cureus

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In this report, we present two cases of refractory chronic lower extremity tendinopathies treated with collagen bioinductive implant augmentation: a 20-year-old male football player with chronic patellar tendinopathy and a 40-year-old active female with chronic proximal hamstring tendinopathy. We demonstrate that bioaugmentation may represent an effective strategy in the surgical treatment of chronic tendinopathies. Both patients were able to return to their pre-injury activity levels at an accelerated rate.

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Patient-Reported Outcomes After Use of a Bioabsorbable Collagen Implant to Treat Partial and Full-Thickness Rotator Cuff Tears

Cited by 40 publications

References 38 publications

Deltoid fascia disruption from the use of a bioinductive collagen scaffold and polyether ether ketone (PEEK) bone staples: a case report

Deltoid fascia disruption from the use of a bioinductive collagen scaffold and polyether ether ketone (PEEK) bone staples: a case report

Enthesis trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model

Bioinductive Collagen Implant Augmentation for the Repair of Chronic Lower Extremity Tendinopathies: A Report of Two Cases

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