Patient-Reported Outcomes After Neoadjuvant Chemoradiotherapy for Rectal Cancer

Pucciarelli, Salvatore; Bianco, Paola Del; Efficace, Fabio; Serpentini, Samantha; Capirci, Carlo; Paoli, Antonino De; Amato, Antonio; Cuicchi, Dajana; Nitti, Donato

doi:10.1097/sla.0b013e3181fcb856

Cited by 92 publications

(54 citation statements)

References 29 publications

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“…Reportedly, pre-and postoperative radiotherapy is associated with significant long-term decreased sexual and urinary function, with accompanying negative effects on patients' quality of life [6,7]. Luckily, neoadjuvant (NA) therapy also includes chemotherapy, which seems to have fewer effects on sexual and urinary functions [8].…”

Section: Introductionmentioning

confidence: 99%

Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report

Huang

Lin

et al. 2016

Int J Colorectal Dis

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Section: Introductionmentioning

confidence: 99%

Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report

Huang

Lin

et al. 2016

Int J Colorectal Dis

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“…In these studies more bowel and sexual dysfunction was found after RT [4][5][6], although they concluded that sexual dysfunction was primarily caused by surgery [7]. In the few available longitudinal HRQL studies, the follow-up was at most until four years after treatment [8][9][10]. The main objective of this study was to present a longitudinal comprehensive overview of HRQL and symptoms of rectal cancer patients in the TME trial until 14 years after treatment.…”

mentioning

confidence: 99%

A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial

et al. 2015

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Background: Total mesorectal excision (TME) combined with preoperative short-term radiotherapy (PRT) reduces local recurrence rates in rectal cancer treatment. However, treatment with radiotherapy increased morbidity and did not result in a longer survival. The aim of this analysis is to provide a comprehensive longitudinal overview of the health-related quality of life (HRQL) and symptoms experienced by rectal cancer patients in the Dutch randomized TME trial from baseline until 14 years after treatment. Methods: Rectal cancer patients (n ¼1530) were randomly allocated to PRT (5 Â 5 Gy) followed by TME or to TME alone. At baseline, 3, 6, 12, 18, and 24 months, 5 years and 14 years after treatment HRQL was evaluated in surviving patients (n ¼606, at 14 years after treatment). Results: None of the general symptoms differed significantly between PRT + TME and TME. However, in both treatment arms the general symptoms were increased at the diagnosis of rectal cancer, after surgery and by aging. With PRT + TME bowel symptoms were increased, specifically more fecal incontinence was reported at all time points, resulting in more use of pads for fecal incontinence (PRT + TME vs. TME at 5 years 51.5% vs. 30.5%, respectively, and at 14 years 56.4% vs. 37.1%, respectively).Conclusions: This longitudinal analysis shows that general symptoms in both groups are increased at the diagnosis of rectal cancer, after surgery and by aging, but not by RT. However, irradiated patients reported more bowel dysfunction at all time points.

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“…In the Norwegian cancer register a significant deterioration in sexual function was also seen 4.5 years after treatment in male patients who underwent adjuvant radio-chemotherapy or neoadjuvant radiotherapy (17) compared with patients who did not undergo such therapy. After neoadjuvant radio-chemotherapy sexual function in men was significantly worse compared with patients who did not receive neoadjuvant treatment (126,135,167). In contrast, in women sexual function is not affected to the same extent by radiation therapy (16,126,132).…”

Section: Adjuvant and Neoadjuvant Radio-and Radio-chemotherapy And Dymentioning

confidence: 81%

Causes and Prevention of Functional Disturbances Following Low Anterior Resection for Rectal Cancer

Gross¹

2011

Rectal Cancer - A Multidisciplinary Approach to Management

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Patient-Reported Outcomes After Neoadjuvant Chemoradiotherapy for Rectal Cancer

Abstract: These findings add to the body of evidence available regarding pCRT and help clinicians to make more informed treatment decisions.

Cited by 92 publications

References 29 publications

Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report

Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report

A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial

Causes and Prevention of Functional Disturbances Following Low Anterior Resection for Rectal Cancer

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