“… - Age : In 38 studies [ 2 , 29 – 49 , 133 , 134 , 136 , 138 , 140 , 144 – 151 , 153 , 154 , 157 ], the relationship between age and HRQoL was reported. The majority of those studies ( n = 24) found a significant correlation with age, mainly indicating that older age was an independent predictor of reduced HRQoL [ 2 , 29 , 31 , 33 , 35 – 37 , 41 , 42 , 44 , 133 , 134 , 136 , 138 , 145 – 147 , 149 , 153 , 154 , 157 ], disablement [ 46 , 152 ], and use of pain medication [ 149 ]. In some studies, the cut-off age for poor HRQoL was further specified: worse HRQoL was demonstrated in patients ≥ 55 [ 31 , 138 , 150 ], ≥ 60 [ 29 ], > 65 [ 139 , 148 , 154 ] and > 80 years [ 146 , 147 ].
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