Patient-reported outcomes 1 year after oesophageal cancer surgery

Schandl, Anna; Johar, Asif; Anandavadivelan, Poorna; Vikström, Karin; Mälberg, Kalle; Lagergren, Pernilla

doi:10.1080/0284186x.2020.1741677

Cited by 41 publications

(57 citation statements)

References 41 publications

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“…Detailed description of the OSCAR study has been presented elsewhere. 20 In brief, it includes 1-year esophageal cancer survivors without cognitive dysfunction who underwent curative-intent esophagectomy in Sweden from 1 January 2013 onwards (response rate around 66%). 20 Eligible patients are identified through collaboration with pathology departments at eight hospitals performing esophagectomy in Sweden.…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

Higher Dispositional Optimism Predicts Better Health-Related Quality of Life After Esophageal Cancer Surgery: A Nationwide Population-Based Longitudinal Study

et al. 2021

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Purpose To assess whether higher dispositional optimism could predict better health-related quality of life (HRQL) after esophageal cancer surgery. Methods This Swedish nationwide longitudinal study included 192 patients who underwent esophagectomy for cancer. The exposure was dispositional optimism measured by the Life Orientation Test-Revised (LOT-R) at 1 year post-surgery. Patients were categorized into four subgroups (very low, moderately low, moderately high, and very high dispositional optimism) based on the quartile of the LOT-R sum score. The outcome was HRQL assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Esophago-Gastric module 25 (QLQ-OG25) at 1, 1.5, and 2 years post-surgery. Linear mixed-effects models, adjusted for potential confounders, were used to examine the mean score difference (MSD) with 95% confidence interval of HRQL among the four patient subgroups. Results Patients with very high dispositional optimism reported clinically relevantly better global quality of life, emotional function, and social function (MSD range 10–16) and less severe symptoms in pain, dyspnea, diarrhea, eating difficulty, anxiety, dry mouth, trouble with taste, worry about weight loss, and self-doubt about body image (MSD range − 9 to − 22) than patients with lower dispositional optimism. Patients with moderately high dispositional optimism reported clinically and statistically significantly better global quality of life (MSD 10) and less severe diarrhea (MSD − 9) than patients with lower dispositional optimism. Adjusted MSDs were constant over the three time points in all aspects except for eating difficulty. Conclusions Measuring dispositional optimism could help identify patients at higher risk of poor HRQL recovery after esophageal cancer surgery.

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Section: Study Design and Data Collectionmentioning

confidence: 99%

Higher Dispositional Optimism Predicts Better Health-Related Quality of Life After Esophageal Cancer Surgery: A Nationwide Population-Based Longitudinal Study

et al. 2021

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“…This nationwide prospective study includes patients who underwent surgery for esophageal cancer between 2013 and 2019 in Sweden. Patients who survived 1 year after surgery and had no cognitive impairments are included in the Esophageal Surgery on Cancer patients -Adaptation and Recovery (OSCAR) study [10]. In brief, consenting patients were followed up regarding HRQL, symptoms and functions during a 5-year period.…”

Section: Methodsmentioning

confidence: 99%

Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors

et al. 2021

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Purpose: The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes. Methods: A prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. The participants responded to a few scales and items from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. Regression models adjusted for potential confounders were used to examine mean score differences (MSD) with 95% confidence intervals (CI) between compliance with the recommendations and HRQL. Results: In total, 134 individuals participated in the study. At 5 weeks, a reduction in role function was seen for individuals who fully (MSD À8, 95% CI: À16 to 0) and to a large extent (MSD À19, 95% CI: À26 to À12) complied with the recommendations. Less fatigue (MSD 9, 95% CI: 3-15) was also detected for this group. Being female, elderly, having comorbidities, living in a region with higher COVID-19 incidence, living in a villa, and being considered as an at-risk person were related to changes in role function. At 13 weeks, reductions in role function continued for those who fully complied with the recommendations (MSD À10, 95% CI: À19 to À1), but the risk variables were of less importance. Improvements in fatigue were no longer detected. Global quality of life, emotional function, or insomnia remained stable over time. Conclusions: This study indicates that individuals who undergone surgery for esophageal cancer and fully or to a large extent complied with the recommendations experienced reductions in role function, but not in global quality of life or emotional function, during the COVID-19 pandemic.

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“…Eligible patients were identified through collaboration with eight pathology departments in all Swedish hospitals where these operations were conducted. The cohort has been described in detail elsewhere [12]. The Regional Ethical Review Board in Stockholm, Sweden (diary number 2013/844-31/1), approved the project and all participants gave informed consent.…”

Section: Methodsmentioning

confidence: 99%

Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery

et al. 2021

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Purpose Esophagectomy for cancer is an extensive procedure often followed by severe complications. This study investigated whether patients with severe symptoms of reflux are more likely to have sleep disturbances and reduced health-related quality of life (HRQL) after esophagectomy. Methods This Swedish nationwide prospective cohort study encompassed all patients who had undergone esophagectomy for cancer between 2013 and 2018. One year after surgery, the patients responded to three questionnaires on reflux (EORTC QLQOG25), sleep disturbances (KSQ), and HRQL (EORTC QLQ-C30). Multivariable logistic regression provided odds ratios (OR) with 95% confidence intervals (CI) for sleep disturbance/reduced HRQL between patients with and without reflux, adjusted for potential confounders. Results Among 241 esophagectomy patients, 66 (27%) reported severe reflux. Patients with reflux had an increased risk of sleep disturbances (OR 2.3, 95% CI: 1.3–4.3) compared to patients without reflux. More specifically, these patients were more likely to suffer from poor sleep quality (OR 4.9, 95% CI: 1.9–12.4). Patients with reflux and sleep disturbances reported reductions in global quality of life, role function, emotional function, social function, and more symptoms in all scales, except for dyspnea. Conclusions This study suggests that patients with severe symptoms of reflux after esophagectomy have an increased risk of sleep disturbances and poor sleep quality, which in turn are associated with reduced HRQL. Implications for Cancer Survivors Alleviating reflux after oesophageal cancer surgery is important, since this common symptom might reduce HRQL and well-being.

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Patient-reported outcomes 1 year after oesophageal cancer surgery

Cited by 41 publications

References 41 publications

Higher Dispositional Optimism Predicts Better Health-Related Quality of Life After Esophageal Cancer Surgery: A Nationwide Population-Based Longitudinal Study

Higher Dispositional Optimism Predicts Better Health-Related Quality of Life After Esophageal Cancer Surgery: A Nationwide Population-Based Longitudinal Study

Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors

Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery

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