Patient-Reported Outcome Measures for Health-Related Quality of Life in Patients With Acne Vulgaris

Abstract

ImportanceMultiple patient-reported outcome measures (PROMs) for health-related quality of life (HRQoL) exist for patients with acne. However, little is known about the content validity and other measurement properties of these PROMs.ObjectiveTo systematically review PROMs for HRQoL in adults or adolescents with acne.Data SourcesEligible studies were extracted from PubMed and Embase (OVID).Study SelectionFull-text articles published in English or Spanish on development, pilot, or validation studies for acne-specific, dermatology-specific, or generic HRQoL PROMs were included. Development studies included original development studies, even if not studied in acne patients per Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) recommendations. If a study included several diagnoses, the majority (ie, over 50%) of patients must have acne or acne-specific subgroup analyses must be available. Abstract and full-text screening was performed by 2 independent reviewers.Data Extraction and SynthesisTwo independent reviewers assessed study quality applying the COSMIN checklist and extracted and analyzed the data. For each distinctive PROM, quality of evidence was graded by measurement property.Main Outcomes and MeasuresPROM properties (target population, domains, recall period, development language), PROM development and pilot studies, content validity (relevance, comprehensiveness, comprehensibility), and remaining measurement properties (structural validity, internal consistency, cross-cultural validity, reliability, measurement error, criterion validity, construct validity, and responsiveness). Quality of evidence was assigned for each measurement property of included PROMs. An overall recommendation level was assigned based on content validity and quality of the evidence of measurement properties.ResultsWe identified 54 acne PROM development or validation studies for 10 acne-specific PROMs, 6 dermatology-specific PROMs, and 5 generic PROMs. Few PROMs had studies for responsiveness. The only acne-specific PROMs with sufficient evidence for content validity were the CompAQ and Acne-Q. Based on available evidence, the Acne-Q and CompAQ can be recommended for use in acne clinical studies.Conclusions and RelevanceTwo PROMs can currently be recommended for use in acne clinical studies: the Acne-Q and CompAQ. Evidence on content validity and other measurement properties were lacking for all PROMs; further research investigating the quality of remaining acne-specific, dermatology-specific, and generic HRQoL PROMs is required to recommend their use.

Tratamento da Acne com Ozonioterapia: Uma Revisão da Literatura

“…Todavia, a crescente resistência da C. acnes aos antibióticos disponíveis, a ineficácia de outros tratamentos, bem como as reações adversas locais, como a irritação cutânea, eritema, secura e descamação são os maiores problemas associados à falta de compliance por parte dos pacientes. Assim, a ozonoterapia figura numa alternativa terapêutica para o tratamento da acne (LOPES, 2020;SILVA;PEREIRA, 2018;HOPKINS, 2022).…”

“…O tratamento da acne se dá de acordo com determinados fatores desencadeantes de sua patogênese, como: controle da produção de sebo, normalização da epitelização folicular, inibição da proliferação bacteriana e amenização da inflamação. Para o sucesso da terapêutica, é fundamental identificar o tipo e a severidade da acne, sendo a acne mais branda tratada somente com produtos de uso tópico, enquanto a moderada e severa requerem associação com tratamento sistêmico (MELNIK, 2018;VORA;SRIVASTAVA;MODI, 2018;HOPKINS, 2022). A tabela 1 a seguir apresenta os graus de severidade da acne.…”

“…Classifica-se como acne de início tardio e acne persistente. O tipo persistente é o mais comum, representando 70% a 80% dos casos, e é definida pela manifestação inaugural após os 25 anos de idade, com uma prevalência de cerca de 20% a 30%" (COSTA; VELHO, 2018;HOPKINS et al, 2022;MAVRANEZOULI, 2022).…”

Systematic review of content and phrasing of patient-reported outcome measures used in patients with psoriasis

“…PROMs assessing health-related quality of life among patients with psoriasis were identified by a systematic review (personal communication; PROSPERO registration: CRD42017075580). 3 For each PROM item, content and phrasing (positive, negative, neutral) were evaluated. 4 Each item was assigned 3 levels of coding (domain, subdomain, and health concepts) as informed by Patient-Reported Outcomes Measurement Information Systems.…”

“… 4 Each item was assigned 3 levels of coding (domain, subdomain, and health concepts) as informed by Patient-Reported Outcomes Measurement Information Systems. 3 Coding was performed by 3 researchers (H.A.H., J.Y., J.S.B.) with iterative development of the codebook until all concepts were comprehensively described with inter-coder consensus.…”